Epigenetics News and Research

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Epigenetics is the study of chemical reactions that influence gene expression, through activation or deactivation of genes at specific times and locations.

Allergy transmission may be gender specific

Parents with allergies are more likely to pass them on to their same gender children than to children of the opposite gender, say researchers.

17 Aug 2012

Acute stress modifies DNA methylation and activity of certain genes

Acute stress alters the methylation of the DNA and thus the activity of certain genes. This is reported by researchers at the Ruhr-Universität Bochum together with colleagues from Basel, Trier and London for the first time in the journal Translational Psychiatry. "The results provide evidence how stress could be related to a higher risk of mental or physical illness", says Prof. Dr. Gunther Meinlschmidt from the Clinic of Psychosomatic Medicine and Psychotherapy at the LWL University Hospital of the RUB.

16 Aug 2012

Researchers identify new gene in Cornelia deLange syndrome

Genetics researchers have identified a key gene that, when mutated, causes the rare multisystem disorder Cornelia deLange syndrome (CdLS). By revealing how mutations in the HDAC8 gene disrupt the biology of proteins that control both gene expression and cell division, the research sheds light on this disease, which causes intellectual disability, limb deformations and other disabilities resulting from impairments in early development.

13 Aug 2012

Epigenetic factors involved in treatment-resistance to schizophrenia drugs

Researchers at Mount Sinai School of Medicine may have discovered why certain drugs to treat schizophrenia are ineffective in some patients. Published online in Nature Neuroscience, the research will pave the way for a new class of drugs to help treat this devastating mental illness, which impacts one percent of the world's population, 30 percent of whom do not respond to currently available treatments.

13 Aug 2012

HDAC8 gene mutations cause Cornelia deLange syndrome

13 Aug 2012

New England Biolabs releases Q5 High-Fidelity DNA Polymerase

New England Biolabs (NEB) has released a novel DNA polymerase, Q5 High-Fidelity DNA Polymerase, that provides the highest fidelity amplification currently available, while also offering robust amplification across the broadest range of amplicons, including those that are GC- and AT-rich.

From New England Biolabs 9 Aug 2012

CPRIT awards $48.2 million in new grants to investigators at UT Southwestern Medical Center

The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded $48.2 million in new grants to investigators at UT Southwestern Medical Center to support cancer-related projects and to recruit pre-eminent cancer researchers.

6 Aug 2012

SAGE Labs, Autism Speaks expand partnership to create first rat models for translational research

Autism Speaks, the world's leading autism science and advocacy organization, today announced its expanded collaboration with Sigma Advanced Genetic Engineering (SAGE) Labs, an initiative of Sigma- Life, to develop the first rat models with modified autism associated genes, intended to accelerate discovery and translational autism research.

3 Aug 2012

MDxHealth’s Irvine, California and CLIA laboratory receive CAP accreditation

MDxHealth SA, a leading molecular diagnostic company that develops and commercializes epigenetic tests to support cancer treatment, today announced that the company's Irvine, California, CLIA laboratory has received College of American Pathology (CAP) accreditation.

1 Aug 2012

Researchers discover new approach to treat two lethal metastatic cancers

A potentially powerful new approach to treating two lethal metastatic cancers - triple negative breast cancer and clear cell renal cell carcinoma, the most common form of kidney cancer - has been discovered by researchers at Mayo Clinic in Florida.

1 Aug 2012

High choline intake during pregnancy may improve how a child responds to stress

If you're sick from stress, a new research report appearing in the August 2012 issue of The FASEB Journal suggests that what your mother ate-or didn't eat-may be part of the cause.

31 Jul 2012

PedBrain Tumor network publishes evaluation of first 125 genome analyses of medulloblastomas

Brain tumors are the primary cause of cancer mortality in children. Even if a cure is possible, young patients often suffer from the stressful treatment which can be harmful to the developing brain. The most common childhood brain tumors are medulloblastoma and pylocytic astrocytoma.

27 Jul 2012

Scientists demonstrate link between cancer and faulty differentiation of stem cells

Stem cells hold great promise for the medicine of the future, but they can also be a cause of disease. When these self-renewing, unspecialized cells fail to differentiate into diverse cell types, they can start dividing uncontrollably, leading to cancer. Already several decades ago, Weizmann Institute scientists were among the first to demonstrate the link between cancer and the faulty differentiation of stem cells. Now a new Weizmann Institute-led study, published in Molecular Cell, reveals a potential molecular mechanism behind this link.

24 Jul 2012

Researchers identify several gene mutations responsible for medulloblastoma

Researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital have identified several gene mutations responsible for the most common childhood brain tumor, called medulloblastoma, adding evidence to the theory that the diagnosis is a group of genetically distinct cancers with different prognoses. These and accompanying findings are likely to lead to less-toxic, better-targeted treatment approaches over the next two years, the researchers said.

23 Jul 2012

Keystone Symposia on Molecular and Cellular Biology receives Gates Foundation grant

Keystone Symposia on Molecular and Cellular Biology is pleased to announce that it has received a fourth grant from the Bill & Melinda Gates Foundation to promote discoveries that will solve urgent global health problems via support of infectious disease conferences in the "Keystone Symposia Global Health Series."

20 Jul 2012

SGC, Life Technologies to generate first-ever master set of epigenetic recombinant antibodies

Life Technologies Corporation today announced it has signed a collaborative partnership with the Structural Genomics Consortium (SGC), and several groups of leading expert scientists in antibody technology at the Universities of Chicago and Toronto, to generate a first-ever master set of quality epigenetic recombinant antibodies for use in disease-related research.

20 Jul 2012

New research sheds light on pluripotency

New research at the Hebrew University of Jerusalem sheds light on pluripotency-the ability of embryonic stem cells to renew themselves indefinitely and to differentiate into all types of mature cells.

19 Jul 2012

Newborn size may predict paternal diabetes risk

The parents of newborn babies who are small are at increased risk for developing diabetes later in life, suggest findings from a study of an Indian population.

10 Jul 2012

Scientists discover two key epigenetic regulating genes that govern stem cell differentiation

The ability to control whether certain stem cells ultimately become bone cells holds great promise for regenerative medicine and potential therapies aimed at treating metabolic bone diseases. Now, UCLA School of Dentistry professor and leading cancer scientist Dr. Cun-Yu Wang and his research team have made a significant breakthrough in that direction. The scientists have discovered two key epigenetic regulating genes that govern the cell-fate determination of human bone marrow stem cells.

10 Jul 2012

New epigenetic path toward a cure for osteoarthritis

In what could be a breakthrough in the practical application of epigenetic science, U.K. scientists used human tissue samples to discover that those with osteoarthritis have a signature epigenetic change (DNA methylation) responsible for switching on and off a gene that produces a destructive enzyme called MMP13.

7 Jul 2012

Epigenetics News and Research

Further Reading

Allergy transmission may be gender specific

Acute stress modifies DNA methylation and activity of certain genes

Researchers identify new gene in Cornelia deLange syndrome

Epigenetic factors involved in treatment-resistance to schizophrenia drugs

HDAC8 gene mutations cause Cornelia deLange syndrome

New England Biolabs releases Q5 High-Fidelity DNA Polymerase

CPRIT awards $48.2 million in new grants to investigators at UT Southwestern Medical Center

SAGE Labs, Autism Speaks expand partnership to create first rat models for translational research

MDxHealth’s Irvine, California and CLIA laboratory receive CAP accreditation

Researchers discover new approach to treat two lethal metastatic cancers

High choline intake during pregnancy may improve how a child responds to stress

PedBrain Tumor network publishes evaluation of first 125 genome analyses of medulloblastomas

Scientists demonstrate link between cancer and faulty differentiation of stem cells

Researchers identify several gene mutations responsible for medulloblastoma

Keystone Symposia on Molecular and Cellular Biology receives Gates Foundation grant

SGC, Life Technologies to generate first-ever master set of epigenetic recombinant antibodies

New research sheds light on pluripotency

Newborn size may predict paternal diabetes risk

Scientists discover two key epigenetic regulating genes that govern stem cell differentiation

New epigenetic path toward a cure for osteoarthritis

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