Pathophysiology News and Research

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Gut microbes play a starring role in insulin resistance, opening doors for new diabetes treatments

The study reveals a strong association between gut microbial carbohydrate metabolism and insulin resistance, pointing to gut microbes as a key player in metabolic syndrome and type 2 diabetes. Targeting these microbial activities could offer a new therapeutic pathway for improving insulin resistance and overall metabolic health.

4 Sep 2023

The efficacy and safety of anti-androgens in the management of hormonal and clinical features of PCOS

The safety and efficacy of anti-androgens in managing polycystic ovary syndrome (PCOS).

1 Sep 2023

Maternal high-fat diet may alter airway nerves in offspring, leading to asthma

New research points to a novel potential mechanism behind eating a high-fat diet during pregnancy and asthma in the offspring.

31 Aug 2023

Novel non-invasive model may help predict preeclampsia before symptoms

Researchers developed a novel clinical diagnostic screening test to identify pregnancies at risk of developing preeclampsia.

31 Aug 2023

Anesthesiologists can play a greater role in managing patients with substance use disorders

As use and misuse of alcohol, opioids, and psychostimulants continues to increase, anesthesiologists can become a more integral part of the care team managing patients with a Substance Use Disorder (SUD), according to a series of three articles published in the September issue of Anesthesia & Analgesia, the official journal of the International Anesthesia Research Society.

24 Aug 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Alcohol-associated bowel disease: A review of the literature

Alcohol consumption is a significant risk factor for gastrointestinal diseases, including cancer. Alcohol can damage the gastrointestinal tract in several ways.

21 Aug 2023

Is there an association between sleep-disordered breathing and Alzheimer's disease?

Researchers evaluated the impact of sleep-disordered breathing (SDB) on neuroimaging biomarkers of Alzheimer's disease (AD).

21 Aug 2023

How effective is the keto diet for managing PCOS?

Scientists discuss the metabolic advantages of the ketogenic diet in the management of polycystic ovarian syndrome.

21 Aug 2023

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Researchers used genetically modified animal models to investigate the role of the newly discovered Traf2- and NCK-interacting protein kinase (TNIK) in obesity and metabolic dysfunction.

15 Aug 2023

Study detects biomarker changes nearly 30 years before symptom onset of Alzheimer’s disease

A new paper has shown how Alzheimer’s disease pathology comes into being over a period of almost three decades.

10 Aug 2023

New tool can identify psoriasis patients at risk for psoriatic arthritis

In research published in Arthritis & Rheumatology, investigators developed and validated a tool called PRESTO that identifies patients with psoriasis who face an elevated risk for developing psoriatic arthritis and may therefore benefit from preventive therapies.

9 Aug 2023

Study finds genetic overlap between IBS, gastrointestinal diseases, and psychiatric disorders

Researchers characterized the genetic architecture of IBS and investigated genetic overlap with gastrointestinal and psychiatric phenotypes.

8 Aug 2023

Is there an association between migraines and the onset of inflammatory bowel disease?

The link between migraines and the new onset of inflammatory bowel disease (IBD).

4 Aug 2023

Study provides new insights into the intricate cellular processes driving heterotopic ossification

In a new study published on 21 July 2023 by the journal Bone Research, a team of researchers from Johns Hopkins University, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), delved into the contribution of synovial/tendon sheath progenitor cells to heterotopic bone formation.

1 Aug 2023

The effects of oxidative stress on women’s fertility

Scientists review existing literature to assess the relationship between oxidative stress and female infertility.

1 Aug 2023

How effective is physical activity in alleviating obesity-related inflammation in diabetes?

Scientists determine whether physical activity can be used as an effective intervention to mitigate obesity-related inflammation in diabetes.

1 Aug 2023

New method allows the discovery of specific inhibitors of lactate transporter

Scientists from the Giulio Superti-Furga Lab at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, have developed a new method that allows the discovery of specific inhibitors of a lactate transporter associated with cancer and other disease areas.

28 Jul 2023

Targeting chronic endometritis: study reveals potential diagnostic markers

Researchers investigated the gene expression signatures and immune cell involvement in chronic endometritis (CE) for potential diagnostic markers.

25 Jul 2023

Bibliometric analysis reveals research trends connecting Alzheimer's disease and the gut microbiome

Researchers utilize bibliometric analysis to investigate the relationship between the gut microbiome and Alzheimer's disease pathogenesis.

25 Jul 2023

Pathophysiology News and Research

Gut microbes play a starring role in insulin resistance, opening doors for new diabetes treatments

The efficacy and safety of anti-androgens in the management of hormonal and clinical features of PCOS

Maternal high-fat diet may alter airway nerves in offspring, leading to asthma

Novel non-invasive model may help predict preeclampsia before symptoms

Anesthesiologists can play a greater role in managing patients with substance use disorders

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Alcohol-associated bowel disease: A review of the literature

Is there an association between sleep-disordered breathing and Alzheimer's disease?

How effective is the keto diet for managing PCOS?

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Study detects biomarker changes nearly 30 years before symptom onset of Alzheimer’s disease

New tool can identify psoriasis patients at risk for psoriatic arthritis

Study finds genetic overlap between IBS, gastrointestinal diseases, and psychiatric disorders

Is there an association between migraines and the onset of inflammatory bowel disease?

Study provides new insights into the intricate cellular processes driving heterotopic ossification

The effects of oxidative stress on women’s fertility

How effective is physical activity in alleviating obesity-related inflammation in diabetes?

New method allows the discovery of specific inhibitors of lactate transporter

Targeting chronic endometritis: study reveals potential diagnostic markers

Bibliometric analysis reveals research trends connecting Alzheimer's disease and the gut microbiome

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