Pathophysiology News and Research

RSS

Parkinson's-linked mutation makes neurons vulnerable to calcium-induced death

A new study reveals the mechanism by which a genetic mutation linked with Parkinson's disease (PD) renders dopamine neurons particularly vulnerable to cell injury and death.

12 Mar 2009

Iodine in pregnancy, needs, impact and controversy

The American Thyroid Association has recommended that all pregnant and breastfeeding women in the U.S. should take daily supplements containing 150 mcg iodine.

25 Feb 2009

New understanding of genetic signature associated with Alzheimer's disease

Scientists have new information about the complex genetic signature associated with Alzheimer's disease, the leading cause of cognitive decline and dementia in the elderly.

1 Jan 2009

Discovery of new target in brain for treating schizophrenia

Research from the University of Pittsburgh could expand the options for controlling schizophrenia by identifying a brain region that responds to more than one type of antipsychotic drug.

6 Nov 2008

The underdevelopment of a specific brain region may cause schizophrenia

The underdevelopment of a specific region in the brain may lead to schizophrenia in individuals. According to research published today in BioMed Central's open access journal Molecular Brain, dentate gyrus, which is located in the hippocampus in the brain and thought to be responsible for working memory and mood regulation, remained immature in an animal model of schizophrenia.

10 Sep 2008

Antiangiogenic and anti-inflammatory drugs: are they safe?

Since Rofecoxib (Vioxx) was withdrawn from the worldwide market based on the safety findings of the Adenomatous Polyp Prevention on Vioxx (APPROVe) study, the uncertainty around the cardiovascular safety of NSAIDs and COX-2 inhibitors remains and leaves practitioners with difficult management decisions for the hundreds of millions of patients worldwide who continue to require pain-relieving therapy to maintain an acceptable quality of life.

1 Sep 2008

Fluvastatin XL use is associated with improved cardiac outcome after major vascular surgery

The DECREASE III Study which took place in the Netherlands between June 2004 and April 2008, showed that patients treated with Fluvastatin showed an improved cardiac outcome after surgery.

1 Sep 2008

Samaritan Pharmaceuticals granted IND from FDA for HIV drug

Samaritan Pharmaceuticals has announced that it has filed an IND (Investigational New Drug) application for SP-6310 in the treatment of HIV-infected patients with abnormal cortisol levels.

8 Jul 2008

A new search for causes of autism

Dr. Eric Fombonne, from the Research Institute of the MUHC at the Montreal Children's Hospital, is involved in a multi-site consortium to gather DNA samples from 2,000 autism patients and their families over the next three years.

7 May 2008

New journal - Circulation: Heart Failure

The American Heart Association has named the editor of Circulation: Heart Failure, its second of the planned six-publication extension to the weekly flagship journal, Circulation: Journal of the American Heart Association. The journals will be published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

7 May 2008

Hydrogen sulphide may be involved in regulating blood pressure

Hydrogen sulphide is a gas most commonly associated with the smell of stink bombs, sewage and rotten eggs, but a team of researchers from the Peninsula Medical School in the South West of England and King's College London have now identified a role for this gas in regulating blood pressure, according to research published in the leading science journal "Circulation".

29 Apr 2008

Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia

Researchers at the University Hospital of Magdeburg (Germany) have discovered that atrial tachycardia is associated with mitochondrial dysfunction and oxidative stress followed by the activation of the NF-kB signalling pathway with induction of NF-kB target gene expression in atrial tissue.

24 Apr 2008

Stress worsens symptoms of endometriosis

Endometriosis is a poorly understood condition that incapacitates and affects the productivity and lifestyle of millions of women around the world.

8 Apr 2008

Patients at risk of adverse events within 3 months after stopping certain ACS therapy

Patients who receive the anti-platelet medication clopidogrel following an acute coronary syndrome (such as heart attack) appear to be at greater risk of a heart attack or death in the first 90 days after stopping clopidogrel treatment, according to a study in the February 6 issue of JAMA: The Journal of the American Medical Association.

7 Feb 2008

Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells

Researchers are identifying innovative therapeutics for sickle cell anemia that focus on specific factors in the disease's progression, such as the important role of hydration of the red blood cells.

7 Feb 2008

Severe asthma may be a different form of the disease

A multi-center research project to investigate severe asthma has found a key physiological difference between severe and non-severe forms of the disease, a finding that could help explain why those with severe asthma do not respond well to treatment.

31 Jan 2008

Differentiation blocked in tumor stem cells

A new comparison of normal stem cells and cancer stem cells reveals that the cancer stem cells are abnormally trapped at an early stage of development.

8 Jan 2008

Physicians seek strategies to improve the quality of sleep in ICU

The sleep patterns of patients in the intensive care unit are so superficial that they barely spend any time in the restorative stages of sleep that aid in healing, UT Southwestern Medical Center physicians have found.

10 Dec 2007

New drug may restore memory with Alzheimer's disease

A 2006 study by MetLife found that adults over age 55 fear Alzheimer's disease more than cancer, and with good reason. Alzheimer's creeps up on patients and their families, robbing more than half of all Americans over age 85 of their memory and ability to care for themselves.

14 Nov 2007

Even mildly underactive thyroid doubles risk of heart conditions

Individuals with subclinical hypothyroidism - a mildly underactive thyroid only detectable by a blood test - are twice as likely to develop heart failure, compared to those with normal thyroid levels, according to a new study presented on Thursday, Oct. 4, at the 78th Annual Meeting of the American Thyroid Association (ATA) in New York.

4 Oct 2007