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EZH2 protein may aid prognostication in resected NSCLC

A protein called “enhancer of zeste homolog-2” is frequently expressed in non-small-cell lung cancer and may have prognostic value following surgical resection, US researchers believe.

30 Oct 2013

Special issue highlights rapid advances in myopia research

New research on myopia-how it develops, risk and protective factors, and potentially effective measures for prevention and treatment are reported across twenty articles in the November issue of Optometry and Vision Science, official journal of the American Academy of Optometry.

30 Oct 2013

Genetic factors may be the same for specific language impairment and language-impaired autism

In the first molecular genetic study of families with a history of both language impairment and autism, scientists may have uncovered a shared origin for the two conditions, an important step toward explaining why some cases of autism are accompanied by language difficulties and others are not. The study, a collaboration of The Research Institute at Nationwide Children's Hospital with experts at Rutgers University, indicates that a disorder called specific language impairment—one of the most common developmental delays in children—may be caused by the same genetic variants that lead to language difficulties in some children with autism.

30 Oct 2013

Researchers overcome obstacle to using viruses to deliver therapeutic genes

Scientists in The Research Institute at Nationwide Children's Hospital have found a way to overcome one of the biggest obstacles to using viruses to deliver therapeutic genes: how to keep the immune system from neutralizing the virus before it can deliver its genetic payload. In a study published recently in Molecular Therapy, researchers found that giving subjects a treatment to temporarily rid the body of antibodies provides the virus safe passage to targeted cells, allowing it to release a corrective or replacement gene to treat disease.

30 Oct 2013

New research reveals genetic link that connects family members with autism

Lorenzo Miodus-Santini an 11-year-old sixth-grader from Princeton, who was classified as autistic at only 13 months old, was never a big talker. As an infant he didn't babble or coo. When he was a toddler beginning to speak, he would learn one word but forget another.

30 Oct 2013

Low birth weight infants more susceptible to invasive infections

Low birth weight infants are host to numerous microorganisms immediately after birth, and the microbiomes of their mouths and gut start out very similar but differentiate significantly by day 15 according to a study published in mBio-, the online open-access journal of the American Society for Microbiology.

29 Oct 2013

EPFL and UNIL-CHUV scientists create first map of human HIV resistance

The key to future HIV treatment could be hidden right in our own genes. Everyone who becomes infected deploys defense strategies, and some even manage to hold the virus at bay without any therapy at all.

29 Oct 2013

Phase 3 study shows STELARA inhibits structural damage in patients with active psoriatic arthritis

New findings from two integrated Phase 3 Janssen Research & Development, LLC (Janssen)-sponsored studies showed treatment with STELARA- (ustekinumab) resulted in significantly greater inhibition of structural damage in patients with active psoriatic arthritis compared with placebo.

29 Oct 2013

Research findings could help define new vaccination applications

New research from the Masonic Cancer Center, University of Minnesota, and the University of Minnesota Center for Immunology has identified key proteins that influence immune response strategies, a finding that could influence new vaccination approaches.

29 Oct 2013

International researchers identify 11 new genes linked to Alzheimer's disease

An international group of researchers has identified 11 new genes that offer important new insights into the disease pathways involved in Alzheimer's disease. The highly collaborative effort involved scanning the DNA of over 74,000 volunteers-the largest genetic analysis yet conducted in Alzheimer's research-to discover new genetic risk factors linked to late-onset Alzheimer's disease, the most common form of the disorder.

28 Oct 2013

Two related genes underlie development of two rare bone tumours in nearly 100% of patients

Scientists have made a rare discovery that allows them to attribute two types of tumour almost entirely to specific mutations that lie in two related genes.

28 Oct 2013

Rutgers scientists provide new information about rare genetic childhood disorder

Scientists at Rutgers University studying the cause of a rare childhood disease that leaves children unable to walk by adolescence say new findings may provide clues to understanding more common neurodegenerative diseases like Alzheimer's and Parkinson's and developing better tools to treat them.

28 Oct 2013

Hopes Raised For Early Pancreatic Cancer Detection

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25 Oct 2013

Peds21 symposium discusses role of parents, caregivers and early childhood experiences in shaping future health

Recent research has found that a dramatic dance between genes and experience shape the architecture of the developing brain, most profoundly during the first 1,000 days of life.

25 Oct 2013

Researchers study genetic factors associated to metabolic syndrome

Researchers from the Institute of Genomic Medicine carried out a study on genetic factors that can be associated to metabolic syndrome, main trigger of cardiovascular diseases, type II diabetes and obesity, with the goal of identifying high risk populations and influence its treatment in the most effective way.

25 Oct 2013

Obsessive-compulsive disorder and Tourette syndrome are highly heritable

An international research consortium led by investigators at Massachusetts General Hospital (MGH) and the University of Chicago has answered several questions about the genetic background of obsessive-compulsive disorder and Tourette syndrome, providing the first direct confirmation that both are highly heritable and also revealing major differences between the underlying genetic makeup of the disorders.

25 Oct 2013

Study: Gene Expression Classifier test reduces unnecessary surgeries in thyroid nodule assessment

The latest study co-led by a CU School of Medicine researcher has confirmed that a Gene Expression Classifier (GEC) test can drastically reduce the problem of unnecessary surgeries in thyroid nodule assessment.

25 Oct 2013

Diabetic patients may require higher doses of metformin to achieve same anti-cancer activity

A University of Colorado Cancer Center study published online this month in the journal Cell Cycle shows that breast cancer cell growth, motility and aggression is promoted by excess glucose, as experienced by patients with diabetes and metabolic syndrome.

25 Oct 2013

Rice University research reveals 3-way genetic switch for cancer metastasis

Cancer researchers from Rice University have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body. The study found that the on-off switch's dynamics also allows a third choice that lies somewhere between "on" and "off." The extra setting both explains previously confusing experimental results and opens the door to new avenues of cancer treatment.

25 Oct 2013

Research unlocks secrets of mouse behavior to help identify promising psychiatric drugs

Developing psychiatric medications is a long and complex process. Candidate drugs are evaluated and assessed based on their effects on the behavior of animals, usually rats or mice. Each class of drugs, from antidepressants to antipsychotics, is tested differently - often in a labor-intensive process that leaves plenty of room for human error. And there is a growing consensus that current procedures fail to effectively produce new medications.

25 Oct 2013

Genes News and Research

EZH2 protein may aid prognostication in resected NSCLC

Special issue highlights rapid advances in myopia research

Genetic factors may be the same for specific language impairment and language-impaired autism

Researchers overcome obstacle to using viruses to deliver therapeutic genes

New research reveals genetic link that connects family members with autism

Low birth weight infants more susceptible to invasive infections

EPFL and UNIL-CHUV scientists create first map of human HIV resistance

Phase 3 study shows STELARA inhibits structural damage in patients with active psoriatic arthritis

Research findings could help define new vaccination applications

International researchers identify 11 new genes linked to Alzheimer's disease

Two related genes underlie development of two rare bone tumours in nearly 100% of patients

Rutgers scientists provide new information about rare genetic childhood disorder

Hopes Raised For Early Pancreatic Cancer Detection

Peds21 symposium discusses role of parents, caregivers and early childhood experiences in shaping future health

Researchers study genetic factors associated to metabolic syndrome

Obsessive-compulsive disorder and Tourette syndrome are highly heritable

Study: Gene Expression Classifier test reduces unnecessary surgeries in thyroid nodule assessment

Diabetic patients may require higher doses of metformin to achieve same anti-cancer activity

Rice University research reveals 3-way genetic switch for cancer metastasis

Research unlocks secrets of mouse behavior to help identify promising psychiatric drugs

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Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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