Acute Lymphoblastic Leukemia News and Research

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Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells, the cells in the body that normally fight infections. There are two main types of white blood cells-lymphoid cells and myeloid cells. ALL affects lymphoid cells.

FDA approves first CAR T-cell therapy for patients with mantle cell lymphoma

The U.S. Food and Drug Administration granted accelerated approval for brexucabtagene autoleucel (TECARTUS™, formerly KTE-X19) as the first and only CAR T-cell therapy for patients with mantle cell lymphoma (MCL) relapsed or refractory to prior treatments.

28 Jul 2020

Josep Carreras Institute's spin-off aims to develop new immuno-oncological therapeutic tools

The Josep Carreras Leukaemia Research Institute, a public centre pertaining to the Generalitat de Catalunya's (Government of Catalonia) CERCA network, has created the OneChain Immunotherapeutics spin-off, the aim of which is to develop new immuno-oncological therapeutic tools with various preclinical candidates, based on CAR-T technology for different tumors, such as cortical T-cell acute lymphoblastic leukemia (coT-ALL), a rare subtype of leukemia that mainly affects children, and which has a poor prognosis.

20 Jul 2020

Researchers create new tool to identify cancer-causing mutations lurking in 98% of the genome

Gene coding regions constitute 2% of the human genome. St. Jude Children's Research Hospital scientists have developed a computational tool to identify alterations that drive tumor formation in the remaining 98% of the genome.

6 Jul 2020

Researchers receive innovative grants to understand the biological underpinnings of blood cancers

Seeking to ignite the next major breakthroughs to treat blood cancers, The Leukemia & Lymphoma Society (LLS), The Mark Foundation, and The Paul G. Allen Frontiers Group today announced more than $6.75 million awarded to nine of the most exceptional scientists in the field.

1 Jul 2020

Research team solves 40-year old mystery in leukemia treatment

A research team led by the University of Kent and Goethe-University Frankfurt am Main, has solved an almost 40-year old mystery in leukemia therapy and the drug nelarabine.

25 Jun 2020

Researchers investigate nelarabine drug for treating leukemia

Acute lymphoblastic leukemia (ALL) is the most common kind of cancer in children. T-ALL, a subtype that resembles T-lymphocytes, can be treated successfully with the drug nelarabine.

24 Jun 2020

Researchers discover new and improved way to treat poor-prognosis blood cancer

Researchers at Children's Cancer Institute have discovered what could prove a new and improved way to treat the poor-prognosis blood cancer, acute myeloid leukemia or AML.

21 Jun 2020

Drama-based resources help Kingston University nursing students to cope with coronavirus pandemic

A set of drama-based resources to help Kingston University, London nursing students working during the Covid-19 pandemic have been put together through a collaboration with world-leading performing arts school Guildhall School of Music & Drama, London.

21 Jun 2020

Research team generates comprehensive developmental map of human T-cells

Chintan Parekh, MD, of The Saban Research Institute of Children's Hospital Los Angeles, has led a team of investigators that generated a comprehensive roadmap for how T-cells develop in the human thymus.

16 Jun 2020

Damon Runyon Cancer Research Foundation awards $3.2 million to early-career physician-scientists

The Damon Runyon Cancer Research Foundation has named four new Damon Runyon Clinical Investigators.

12 Jun 2020

Study analyzes cancer diagnosis in children with birth defects

Scientific studies suggest that children with birth defects are at increased risk of cancer. However, it has not been assessed whether the type of cancer, the age at which they are diagnosed or the extent of cancer spread at the time of diagnosis, is different for children with birth defects compared to children without birth defects.

29 May 2020

Finding new therapeutic strategies for aggressive T-cell acute lymphoblastic leukemia

Aiming to identify new therapeutic strategies for the aggressive hematological disease T-cell acute lymphoblastic leukemia (T-ALL), Rutgers Cancer Institute of New Jersey resident researcher Daniel Herranz Benito, PhD, along with collaborators from Princeton University, found a new drug that has therapeutic effect against T-ALL by inhibiting SHMT and is complementary to standard-of-care treatment.

12 May 2020

Antioxidant-rich foods can lower risk of infection in children with leukemia

While encouraging children to eat their fruits and veggies is a common refrain for most parents, new research led by a pediatric oncology expert from Roswell Park Comprehensive Cancer Center underscores that diets high in antioxidant-rich foods can have particular benefits for young cancer patients.

2 May 2020

Researchers discover physiological mechanisms underlying pediatric B-ALL

B-cell acute lymphoblastic leukemia (B-ALL) is characterized by the accumulation of abnormal immature B-cell precursors in the bone marrow and is the most common pediatric cancer.

23 Apr 2020

New collaboration may lead to future clinical trials to test treatment for leukemia

In a new pre-clinical study published this week in the journal Leukemia, the research team of Children's Hospital Los Angeles investigator Hisham Abdel-Azim, MD, MS, worked with colleagues to engineer T-cells to identify and target multiple sites on acute lymphoblastic leukemia cells instead of just one. The early collaboration points the way to future clinical trials to test the therapy.

1 Apr 2020

Research could open up new therapeutic strategies for some lung and kidney cancers

New findings from researchers at The University of Texas MD Anderson Cancer Center about how some cancer cells become "addicted" to glucose could open up fresh approaches to therapy strategies for cancers with high levels of an amino acid transporter called solute carrier family 7 member 11 (SLC7A11).

30 Mar 2020

Acute Lymphoblastic Leukemia News and Research

Further Reading

FDA approves first CAR T-cell therapy for patients with mantle cell lymphoma

Josep Carreras Institute's spin-off aims to develop new immuno-oncological therapeutic tools

Researchers create new tool to identify cancer-causing mutations lurking in 98% of the genome

Researchers receive innovative grants to understand the biological underpinnings of blood cancers

Research team solves 40-year old mystery in leukemia treatment

Researchers investigate nelarabine drug for treating leukemia

Researchers discover new and improved way to treat poor-prognosis blood cancer

Drama-based resources help Kingston University nursing students to cope with coronavirus pandemic

Research team generates comprehensive developmental map of human T-cells

Damon Runyon Cancer Research Foundation awards $3.2 million to early-career physician-scientists

Study analyzes cancer diagnosis in children with birth defects

Finding new therapeutic strategies for aggressive T-cell acute lymphoblastic leukemia

Antioxidant-rich foods can lower risk of infection in children with leukemia

Researchers discover physiological mechanisms underlying pediatric B-ALL

New collaboration may lead to future clinical trials to test treatment for leukemia

Research could open up new therapeutic strategies for some lung and kidney cancers

Weakness in lung and kidney cancer cells could serve as therapeutic target

3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

Subpopulations of leukemic cells present at diagnosis can cause relapse in children with ALL

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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