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Restrictions to opioid prescription block their use for safe, effective pain relief

Restrictions to opioid prescription block their use for safe, effective pain relief

Opioids are very effective for treating some types of pain, such as cancer pain and postoperative pain, but not for other kinds of pain like chronic low back pain. An increase in the number of opioid-related deaths among addicts has led to the current movement to restrict opioid prescribing by state and federal authorities. [More]
FDA issues draft guidance to support development of approved ADF opioids

FDA issues draft guidance to support development of approved ADF opioids

The U.S. Food and Drug Administration today issued a draft guidance intended to support industry in their development of generic versions of approved opioids with abuse-deterrent formulations (ADF) while ensuring that generic ADF opioids are no less abuse-deterrent than the brand-name drug. [More]
Sweet foods invoke different brain circuits

Sweet foods invoke different brain circuits

Different brain circuits are invoked by the pleasure we derive from eating sweet foods and the calories they supply. [More]
Researchers develop metastasis-on-a-chip system to advance cancer investigation, drug discovery

Researchers develop metastasis-on-a-chip system to advance cancer investigation, drug discovery

Advances in personalized medicine allow doctors to select the most promising drugs for certain types of malignant tumors. [More]
FDA announces required class-wide safety labeling changes for IR opioid pain medications

FDA announces required class-wide safety labeling changes for IR opioid pain medications

In a continuing effort to educate prescribers and patients about the potential risks related to opioid use, the U.S. Food and Drug Administration today announced required class-wide safety labeling changes for immediate-release (IR) opioid pain medications. Among the changes, the FDA is requiring a new boxed warning about the serious risks of misuse, abuse, addiction, overdose and death. [More]
Changes in substance use policies can significantly impact life expectancy

Changes in substance use policies can significantly impact life expectancy

While average life expectancy has been rising steadily in most countries over the past century, new research led by the Centre for Addiction and Mental Health shows that life expectancy declined significantly and rapidly in three countries where policy changes increased access to prescription opioids, alcohol or illicit drugs. [More]
New reference guide can help HIV care providers treat chronic pain

New reference guide can help HIV care providers treat chronic pain

Recent studies suggest many individuals with HIV have chronic pain. Estimates range from 39 percent all the way to 85 percent. Chronic pain is an important comorbid condition in individuals with HIV, as it is common and causes substantial disability. [More]
Moderate drinking not linked to longer life, study shows

Moderate drinking not linked to longer life, study shows

Many people believe a glass of wine with dinner will help them live longer and healthier--but the scientific evidence is shaky at best, according to a new research analysis. [More]
New RMBF survey shows doctors working under increasing pressure experience mental health issues

New RMBF survey shows doctors working under increasing pressure experience mental health issues

A new survey, released today (22 March 2016) by the Royal Medical Benevolent Fund, highlights the overwhelming concern amongst doctors about the state of their mental health and wellbeing as a result of working under increasing pressure and scrutiny. [More]
KORs could be potential drug target for treatment of addiction, anxiety disorders

KORs could be potential drug target for treatment of addiction, anxiety disorders

University of North Carolina researchers uncovered a cellular mechanism by which kappa opioid receptors (KOR) drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a part of the brain that regulates emotion. [More]
Penn study calls on physicians to avoid over-prescribing opioids for surgical patients

Penn study calls on physicians to avoid over-prescribing opioids for surgical patients

Physicians are prescribing more opioid painkillers than ever before to patients undergoing common surgeries, according to new research from the department of Anesthesiology and Critical Care at the Perelman School of Medicine at the University of Pennsylvania. [More]
Orexigen Therapeutics, Valeant Pharmaceuticals sign distribution agreement for Mysimba

Orexigen Therapeutics, Valeant Pharmaceuticals sign distribution agreement for Mysimba

Orexigen Therapeutics, Inc. today announced Valeant Pharmaceuticals International, Inc. will commercialize Mysimba (naltrexone HCl / bupropion HCl prolonged release) in Central and Eastern Europe. [More]
Research findings could help treat people with sexual disorders

Research findings could help treat people with sexual disorders

Undesirable associations with sex can be unlearned, but return if the circumstances change. They must therefore be unlearned in different situations. The drug D-cycloserine may help here. These are the findings of psychologist Mirte Brom. [More]
Effective ways to ensure a long, healthy life

Effective ways to ensure a long, healthy life

More people may be living to 100 and beyond than ever before, but the real challenge is how to become one of them yourself, and how to care for an aging population. [More]
Gar genome helps identify genetic sequences shared by human disease genes and zebrafish

Gar genome helps identify genetic sequences shared by human disease genes and zebrafish

Led by Drs John Postlethwait and Ingo Braasch from the Institute of Neuroscience, University of Oregon, US, in collaboration with the Broad Institute, the study of the Spotted Gar (Lepisosteus oculatus) genome reveals that it is small and manageable. Furthermore, it lacks much shuffling and duplication that occurred in the 'main' fish ancestral line; it conserved its genome. [More]
IUPUI researcher awarded $1.1 million grant to develop tools to improve care for chronic pain patients

IUPUI researcher awarded $1.1 million grant to develop tools to improve care for chronic pain patients

An Indiana University-Purdue University Indianapolis researcher has been awarded $1.1 million to develop information-based tools to help primary care providers improve care for patients with chronic pain, a condition that affects 100 million Americans at a cost of $630 billion annually in health care costs and lost worker productivity. [More]
Overprescribing of opioids leads to serious public health problems

Overprescribing of opioids leads to serious public health problems

Overprescribing of opioids and opioid addiction are serious and growing public health problems in the U.S., and are the focus of a new report by an expert panel, entitled The American Opioid Epidemic: Population Health Implications and Potential Solutions," from the National Stakeholder Panel, Jefferson College of Population Health, which is published in a special supplement to Population Health Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The supplement is available open access on the Population Health Managementwebsite [More]
Early childhood intervention guide can help prevent substance use disorders

Early childhood intervention guide can help prevent substance use disorders

An online guide about interventions in early childhood that can help prevent drug use and other unhealthy behaviors was launched today by the National Institute on Drug Abuse, part of the National Institutes of Health. [More]
Scientists discover brain mechanisms that separate food consumption from cravings

Scientists discover brain mechanisms that separate food consumption from cravings

Researchers investigating eating disorders often study chemical and neurological functions in the brain to discover clues to overeating. Understanding non-homeostatic eating -- or eating that is driven more by palatability, habit and food cues -- and how it works in the brain may help neuroscientists determine how to control cravings, maintain healthier weights and promote healthier lifestyles. Scientists at the University of Missouri recently discovered the chemical circuits and mechanisms in the brain that separate food consumption from cravings. Knowing more about these mechanisms could help researchers develop drugs that reduce overeating. [More]
Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Inhibiting the transfer of calcium ions into the cell's powerhouse is specifically toxic to cancer cells, according to an article published this week in Cell Reports by researchers from the Perelman School of Medicine at the University of Pennsylvania. [More]
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