Adenosine News and Research

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Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a ß-N9-glycosidic bond.

Schering-Plough starts patient enrollment in phase 3 trial for Acadesine

Schering-Plough Corporation today announced the start of patient enrollment in RED-CABG, the Phase 3 Trial for acadesine, an investigational, potentially first-in-class adenosine regulating agent (ARA). Acadesine was licensed from PeriCor Therapeutics, Inc., a privately held specialty biopharmaceutical company.

12 May 2009

Some orthodontic appliances more prone to bacteria

Researchers at the Oregon Health & Science University School of Dentistry have found the majority of patients with self-ligating orthodontic brackets retain fewer bacteria in plaque than patients with elastomeric orthodontic brackets.

14 Apr 2009

RNA interference can be used to silence genes selectively - potential for Huntington's disease therapy

Howard Hughes Medical Institute researchers have designed tiny RNA molecules that shut off the gene that causes Huntington's disease without damaging that gene's healthy counterpart, which maintains the health and vitality of neurons.

12 Apr 2009

New research should ease constipation

If you hate prune juice and chalky fiber supplements, just sit down and relax.

9 Apr 2009

Gene scan shows body's sleep cycle influences numerous physical functions

The pineal gland - integral to setting the body's sleep and wake cycles - may be involved in a broad range of bodily functions, according to a study by researchers at the National Institutes of Health and other institutions.

30 Mar 2009

Cordex Pharma files ATPace formulation patent

Cordex Pharma, Inc. has announced today that it has filed a formulation patent covering its lead product, ATPace.

4 Mar 2009

Researchers identify molecule that helps the sleep-deprived to mentally rebound

Sleep experts know that the mental clarity lost because of a few sleepless nights can often be restored with a good night's rest. Now, UT Southwestern Medical Center researchers have identified a key molecular mechanism that regulates the brain's ability to mentally compensate for sleep deprivation.

25 Feb 2009

Researchers identify key molecular mechanism that regulates brain's ability to mentally compensate for sleep deprivation

Sleep experts know that the mental clarity lost because of a few sleepless nights can often be restored with a good night's rest.

24 Feb 2009

Brain cells called astrocytes, not neurons, lull the brain to sleep

Brain cells called astrocytes help to cause the urge to sleep that comes with prolonged wakefulness, according to a study in mice, funded by the National Institutes of Health.

2 Feb 2009

E. coli persists against antibiotics through HipA-induced dormancy

Bacteria hunker down and survive antibiotic attack when a protein flips a chemical switch that throws them into a dormant state until treatment abates, researchers at The University of Texas M. D. Anderson Cancer Center report in the Jan.16 edition of Science.

19 Jan 2009

High-fat diet can disrupt our biological clock

Indulgence in a high-fat diet can not only lead to overweight because of excessive calorie intake, but also can affect the balance of circadian rhythms - everyone's 24-hour biological clock, Hebrew University of Jerusalem researchers have shown.

29 Dec 2008

Light drinking has certain health benefits, researchers look at why

While the physiological damage and social havoc created by alcohol abuse and dependency are well-known, it is also true that light-to-moderate drinking has certain health benefits.

20 Nov 2008

Many receptor models used in drug design may not be useful after all

It may very well be that models used for the design of new drugs have to be regarded as impractical. This is the sobering though important conclusion of the work of two Leiden University scientists published in Science this week.

5 Oct 2008

Existing anti-obesity drugs may be effective against flu, hepatitis and HIV

Viruses dramatically increase cellular metabolism, and existing anti-obesity drugs may represent a new way to block these metabolic changes and inhibit viral infection, according to a study published today in the journal Nature Biotechnology.

29 Sep 2008

New cutting edge laser technology provides view into body's chemical messenger system

Researchers at The University of Nottingham have developed a unique technology that will allow scientists to look at microscopic activity within the body's chemical messenger system for the very first time, live as it happens.

28 Aug 2008

Scientists discover reservoir of mitochondrial DNA mutations present in the general population

Researchers at the University of Newcastle, England, and the Virginia Bioinformatics Institute at Virginia Tech in the United States have revealed a large reservoir of mitochondrial DNA mutations present in the general population. Clinical analysis of blood samples from almost 3,000 infants born in north Cumbria, England, showed that at least 1 in 200 individuals in the general public harbor mitochondrial DNA mutations that may lead to disease.

11 Aug 2008

Researchers find key mechanism of cell damage in aging and disease

Researchers have taken a first snapshot of how a class of highly reactive molecules inflicts cellular damage as part of aging, heart disease, stroke, cancer, diabetes, kidney disease and Alzheimer's disease to name a few. According to a study published today in the journal Cell, researchers have discovered a tool that can monitor related damage and determine the degree to which antioxidant drugs effectively combat disease.

24 Jul 2008

Caffeine could help prevent multiple sclerosis

A new study is suggesting that having several cups of coffee a day could halt the development of multiple sclerosis (MS).

2 Jul 2008

tRNA import occurs in humans - could lead to targeted therapies

Scientists have determined that human cells are able to shift important gene products into their own mitochondria, considered the power plants of cells. The finding could eventually lead to therapies for dozens of diseases.

24 Jun 2008

Adult human stem cells shown not to pose a cancer risk when implanted into different organs

A new study by UC Davis researchers provides evidence that methods using human bone marrow-derived stem cells to deliver gene therapy to cure diseases of the blood, bone marrow and certain types of cancer do not cause the development of tumors or leukemia.

6 May 2008