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TSRI scientists identify potential therapeutic target for age- or Alzheimer's disease-related memory deficits

TSRI scientists identify potential therapeutic target for age- or Alzheimer's disease-related memory deficits

Scientists from the Florida campus of The Scripps Research Institute have made an important discovery toward the development of drugs to treat age-related memory loss in diseases like Alzheimer's. [More]
PET imaging can accurately identify difficult-to-diagnose cardiac amyloidosis

PET imaging can accurately identify difficult-to-diagnose cardiac amyloidosis

Reston, Virginia - Researchers at Princess Alexandra Hospital, Brisbane, Australia, have demonstrated that cardiac amyloidosis (abnormal deposits of proteins in the heart), which is notoriously difficult to diagnose, can be visualized noninvasively with positron emission tomography (PET) using the radiotracer fluorine-18 (F-18)-florbetaben. [More]
Icelandic people more likely to carry novel rare genetic variant linked to risk of Alzheimer's disease

Icelandic people more likely to carry novel rare genetic variant linked to risk of Alzheimer's disease

People with Icelandic heritage are more likely to carry a novel rare mutation in the TM2D3 gene, which leads to greater risk for Alzheimer's disease, based on a new study published October 14th, 2016 in PLOS Genetics by Johanna Jakobsdottir of the Icelandic Heart Association, Sven van der Lee of Erasmus University in Rotterdam, and colleagues. [More]
Monoclonal antibody removes brain amyloid plaques in patients with Alzheimer's disease

Monoclonal antibody removes brain amyloid plaques in patients with Alzheimer's disease

Scientists at Neurimmune today described results from the Phase 1b PRIME clinical trial of the monoclonal antibody aducanumab. [More]
New mouse model reveals how Alzheimer's causes dementia

New mouse model reveals how Alzheimer's causes dementia

Using a novel, newly developed mouse model that mimics the development of Alzheimer's disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological "insults" must occur in the brain to cause the dementia that is the hallmark of the disease. [More]
Research highlights association of western diet with Alzheimer's disease

Research highlights association of western diet with Alzheimer's disease

Recent research has established associations between certain environmental factors, including eating a western diet and being sedentary, with an increased susceptibility to Alzheimer's disease. In fact, it is estimated that a combination of diet and inactivity contributes to as many as 25% of Alzheimer's cases. Nonetheless, little is known about the exact disease mechanisms and how or why this increasingly common middle-age lifestyle can play such a big role in subsequent cognitive function. [More]
Immune cells may play greater role in Alzheimer's disease than originally thought

Immune cells may play greater role in Alzheimer's disease than originally thought

Immune cells that normally help us fight off bacterial and viral infections may play a far greater role in Alzheimer's disease than originally thought, according to University of California, Irvine neurobiologists with the Sue & Bill Gross Stem Cell Research Center and the Institute for Memory Impairments and Neurological Disorders. [More]
Experimental drug candidate aimed at combating Alzheimer's disease has anti-aging effects

Experimental drug candidate aimed at combating Alzheimer's disease has anti-aging effects

Salk Institute researchers have found that an experimental drug candidate aimed at combating Alzheimer's disease has a host of unexpected anti-aging effects in animals. [More]
IU-led scientists discover new gene that increases Alzheimer's disease risk

IU-led scientists discover new gene that increases Alzheimer's disease risk

In a newly published study, a multi-institutional team led by scientists at the Indiana University School of Medicine have discovered an immune system gene associated with higher rates of amyloid plaque buildup in the brains of Alzheimer's patients and older adults at risk for the disease. [More]
New drug shows promise in slowing Alzheimer’s disease

New drug shows promise in slowing Alzheimer’s disease

New research findings have fuelled hopes of a drug that can slow down the progression of Alzheimer’s disease. [More]
Study looks at impact of amyloid imaging on diagnosis, management of patients with cognitive impairment

Study looks at impact of amyloid imaging on diagnosis, management of patients with cognitive impairment

Eli Lilly and Company and Avid Radiopharmaceuticals, Inc., a wholly owned subsidiary of Lilly, today announced new data showing that knowledge of amyloid status as determined by Florbetapir F 18 Injection imaging altered diagnosis and management in the majority of patients being studied. [More]
Stanford researchers identify iron-containing microglia in the brains of people with Alzheimer's disease

Stanford researchers identify iron-containing microglia in the brains of people with Alzheimer's disease

Examining post-mortem tissue from the brains of people with Alzheimer's disease, Stanford University School of Medicine investigators identified what appear to be iron-containing microglia -- specialized scavenger cells that sometimes become inflammatory -- in a particular part of the hippocampus, a key brain structure whose integrity is critical to memory formation. [More]
Alzheimer's disease may be 'at work' years ahead of actual symptoms, say IU researchers

Alzheimer's disease may be 'at work' years ahead of actual symptoms, say IU researchers

The best-known genetic variant linked to Alzheimer's disease may be "at work" promoting deposits of plaque in the brain long before any symptoms of the disease can be measured on tests, according to a national research study led by Indiana University School of Medicine investigators. [More]
Neuralstem's HK532-IGF-1 neural stem cells therapy for Alzheimer's disease presented at ISSCR Annual Meeting

Neuralstem's HK532-IGF-1 neural stem cells therapy for Alzheimer's disease presented at ISSCR Annual Meeting

Neuralstem, Inc., a biopharmaceutical company using neural stem cell technology to develop small molecule and cell therapy treatments for central nervous system diseases, announced that the poster "Human Neural Stem Cells Expressing IGF-1: A Novel Cellular Therapy for Alzheimer's Disease" was presented yesterday at the International Society for Stem Cell Research (ISSCR) Annual Meeting in Stockholm, Sweden. [More]
vTv Therapeutics enrolls first patients in azeliragon Phase 3 trial for treatment of mild Alzheimer's disease

vTv Therapeutics enrolls first patients in azeliragon Phase 3 trial for treatment of mild Alzheimer's disease

vTv Therapeutics LLC today announced enrollment of the first patients into STEADFAST (Single Trial Evaluating Alzheimer's Disease Following Addition to Symptomatic Therapy), vTv's Phase 3 placebo controlled trial of azeliragon, an oral antagonist of the Receptor for Advanced Glycation Endproducts (RAGE) for treatment of mild Alzheimer's disease. [More]
Study suggests possible role for caffeine in AD treatment

Study suggests possible role for caffeine in AD treatment

The proposed link between caffeine and reductions in the beta amyloid plaque accumulation characteristic of Alzheimer's disease (AD) suggest a possible role for caffeine in AD treatment. The latest evidence linking beta amyloid protein to Alzheimer's disease and exploring the relationship between caffeine and beta amyloid are featured in a review article in Journal of Caffeine Research: The International Multidisciplinary Journal of Caffeine Science, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. [More]
BAI researchers develop new brain image analysis method to better track amyloid changes

BAI researchers develop new brain image analysis method to better track amyloid changes

Researchers from Banner Alzheimer's Institute have developed a new brain image analysis method to better track the progression of beta-amyloid plaque deposition, a characteristic brain abnormality in Alzheimer's disease, according to a study published in the March issue of the Journal of Nuclear Medicine. [More]
Finding appears to support the hypothesis that Alzheimer's is an autoimmune disease

Finding appears to support the hypothesis that Alzheimer's is an autoimmune disease

Brain levels of the lipid ceramide are high in Alzheimer's disease, and now scientists have found increased levels of an antibody to the lipid in their disease model. [More]
Researchers uncover mechanism by which anti-inflammatory processes may cause Alzheimer's

Researchers uncover mechanism by which anti-inflammatory processes may cause Alzheimer's

Inflammation has long been studied in Alzheimer's, but in a counterintuitive finding reported in a new paper, University of Florida researchers have uncovered the mechanism by which anti-inflammatory processes may trigger the disease. [More]
Eli Lilly, AstraZeneca begin AZD3293 Phase II/III study for treatment of early Alzheimer's disease

Eli Lilly, AstraZeneca begin AZD3293 Phase II/III study for treatment of early Alzheimer's disease

Eli Lilly and Company and AstraZeneca today announced enrollment of the first patient into AMARANTH, a Phase II/III study of an oral beta secretase cleaving enzyme (BACE) inhibitor currently in development as a potential treatment for Alzheimer's disease. [More]
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