Amyloid Plaque News and Research RSS Feed - Amyloid Plaque News and Research

Lilly, AstraZeneca partner to co-develop and commercialize potential Alzheimer's disease treatment

Lilly, AstraZeneca partner to co-develop and commercialize potential Alzheimer's disease treatment

Eli Lilly and Company and AstraZeneca today announced an agreement to co-develop and commercialize AZD3293, an oral beta secretase cleaving enzyme (BACE) inhibitor currently in development as a potential treatment for Alzheimer's disease. [More]
Alzheimer's disease report success in harnessing mouse's immune system to attack toxic proteins

Alzheimer's disease report success in harnessing mouse's immune system to attack toxic proteins

Alzheimer's disease experts at NYU Langone Medical Center and elsewhere are reporting success in specifically harnessing a mouse's immune system to attack and remove the buildup of toxic proteins in the brain that are markers of the deadly neurodegenerative disease. [More]
Study shows bryostatin plays key role in slowing or reversing Alzheimer's disease

Study shows bryostatin plays key role in slowing or reversing Alzheimer's disease

Neurotrope, Inc. (OTCQB: NTRP) today announced that results from a new study, entitled, "PKCe Deficits in Alzheimer's Disease Brains and Skin Fibroblasts," published in the recent edition of the peer-reviewed Journal of Alzheimer's Disease and co-authored by Tapan K. Khan, Ph.D.; Abhik Sen, Ph.D.; Jarin Hongpaisan, Ph.D.; Chol S. Lim, Ph.D.; Thomas J. Nelson, Ph.D., and; Dr. Daniel L. Alkon, each of the Blanchette Rockefeller Neurosciences Institute (BRNI), provide further indication of the role that protein kinase C epsilon (PKCe) may play in the potential treatment of Alzheimer's disease (AD). [More]
New discovery links two important hypotheses in Alzheimer's disease research

New discovery links two important hypotheses in Alzheimer's disease research

In Alzheimer's disease, accumulation of amyloid plaque in the brain is believed to play an important role in many characteristic disease symptoms, including memory loss and other mental state changes. [More]
Scientists build artificial cells programmed to eat their undesirable neighbors

Scientists build artificial cells programmed to eat their undesirable neighbors

A team of researchers has devised a Pac-Man-style power pellet that gets normally mild-mannered cells to gobble up their undesirable neighbors. The development may point the way to therapies that enlist patients’ own cells to better fend off infection and even cancer, the researchers say. A description of the work will be published July 15 in the journal Science Signaling. [More]
Noninvasive optical imaging device helps to detect changes linked with Alzheimer's disease

Noninvasive optical imaging device helps to detect changes linked with Alzheimer's disease

A noninvasive optical imaging device developed at Cedars-Sinai can provide early detection of changes that later occur in the brain and are a classic sign of Alzheimer's disease, according to preliminary results from investigators conducting a clinical trial in Australia. [More]
Eye exam for beta-amyloid correlates with levels in brain, detects people with Alzheimer's

Eye exam for beta-amyloid correlates with levels in brain, detects people with Alzheimer's

A decreased ability to identify odors might indicate the development of cognitive impairment and Alzheimer's disease, while examinations of the eye could indicate the build-up of beta-amyloid, a protein associated with Alzheimer's, in the brain, according to the results of four research trials reported today at the Alzheimer's Association International Conference- 2014 (AAIC- 2014) in Copenhagen. [More]
New Tel Aviv University study finds link between Alzheimer's and brain hyperactivity

New Tel Aviv University study finds link between Alzheimer's and brain hyperactivity

Patients with Alzheimer's disease run a high risk of seizures. While the amyloid-beta protein involved in the development and progression of Alzheimer's seems the most likely cause for this neuronal hyperactivity, how and why this elevated activity takes place hasn't yet been explained - until now. [More]
New investigational drug can slow memory loss in older Individuals with risk for developing AD in future

New investigational drug can slow memory loss in older Individuals with risk for developing AD in future

A new research study at Rush University Medical Center and Northwestern Medicine is testing whether a new investigational treatment can slow the memory loss caused by Alzheimer's disease. [More]
Late-life depression could become major risk factor for developing Alzheimer's

Late-life depression could become major risk factor for developing Alzheimer's

Many people develop depression in the latest stages of life, but until now doctors had no idea that it could point to a build up of a naturally occurring protein in the brain called beta-amyloid, a hallmark of Alzheimer's disease. [More]
Suppressing hyperactivity of calcium channels alleviates familial Alzheimer's disease

Suppressing hyperactivity of calcium channels alleviates familial Alzheimer's disease

In 2008, researchers at the Perelman School of Medicine at the University of Pennsylvania showed that mutations in two proteins associated with familial Alzheimer's disease (FAD) disrupt the flow of calcium ions within neurons. [More]
Researchers develop gene therapy reversing memory loss in mice with early-stage Alzheimer's

Researchers develop gene therapy reversing memory loss in mice with early-stage Alzheimer's

Alzheimer's disease is the first cause of dementia and affects some 400,000 people in Spain alone. However, no effective cure has yet been found. One of the reasons for this is the lack of knowledge on the cellular mechanisms which cause alterations in nerve transmissions and the loss of memory in the initial stages of the disease. [More]
Scientists develop new mechanism that helps decode amyloid plaque formation in brains of Alzheimer's patients

Scientists develop new mechanism that helps decode amyloid plaque formation in brains of Alzheimer's patients

University of Michigan researchers have learned how to fix a cellular structure called the Golgi that mysteriously becomes fragmented in all Alzheimer's patients and appears to be a major cause of the disease. [More]
Plaque in brain could guide treatment decisions for patients at risk for Alzheimer's

Plaque in brain could guide treatment decisions for patients at risk for Alzheimer's

Brain imaging using radioactive dye can detect early evidence of Alzheimer's disease that may predict future cognitive decline among adults with mild or no cognitive impairment, according to a 36-month follow-up study led by Duke Medicine. [More]
Scientists identify critical regulator of molecule deeply involved in progression of Alzheimer's

Scientists identify critical regulator of molecule deeply involved in progression of Alzheimer's

Scientists from the Florida campus of The Scripps Research Institute have identified a critical regulator of a molecule deeply involved in the progression of Alzheimer's disease. [More]
Scientists identify critical regulator of molecule involved in progression of Alzheimer’s disease

Scientists identify critical regulator of molecule involved in progression of Alzheimer’s disease

Scientists from the Florida campus of The Scripps Research Institute have identified a critical regulator of a molecule deeply involved in the progression of Alzheimer’s disease. [More]
Study: Cholesterol levels linked to early signs of Alzheimer's disease in the brain

Study: Cholesterol levels linked to early signs of Alzheimer's disease in the brain

High levels of "good" cholesterol and low levels of "bad" cholesterol are correlated with lower levels of the amyloid plaque deposition in the brain that is a hallmark of Alzheimer's disease, in a pattern that mirrors the relationship between good and bad cholesterol in cardiovascular disease, UC Davis researchers have found. [More]
Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

A study in mice shows how a breakdown of the brain's blood vessels may amplify or cause problems associated with Alzheimer's disease. The results published in Nature Communications suggest that blood vessel cells called pericytes may provide novel targets for treatments and diagnoses. [More]

Merck provides update on MK-8931 investigational oral therapy for Alzheimer’s disease

Merck, known as MSD outside the United States and Canada, today provided an update on the development program for MK-8931, a novel investigational oral β-amyloid precursor protein site-cleaving enzyme (BACE) inhibitor. [More]
Immunologists receive $4.8M grant to target multiple diseases by manipulating enzyme

Immunologists receive $4.8M grant to target multiple diseases by manipulating enzyme

Immunologists Barbara A. Osborne and Lisa M. Minter at the University of Massachusetts Amherst, as part of a multi-institution research team, will share a five-year, $4.8 million National Cancer Institute grant to target multiple diseases including cancer, Alzheimer's and graft-versus-host disease (GVHD) by manipulating an enzyme that activates over 100 different protein substrates in the body. [More]