Amyloid Plaque News and Research

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Using antibodies to detect Alzheimer’s disease

News-Medical speaks to Professor Vendruscolo about his research that uses antibodies to detect Alzheimer's disease, which could help to improve drug discovery.

8 Jun 2020

Findings indicate potential therapeutic interventions for Alzheimer’s and other diseases

A team of scientists from Japan recently achieved more efficient degradation of the human serum albumin protein-;an important protein in the blood-;via high-intensity infrared irradiation, by attaching a zinc metal complex to the protein.

1 Jun 2020

Study reveals how APOE4 triggers leaks in the blood-brain barrier

New USC research reveals how APOE4, a genetic culprit for Alzheimer's disease, triggers leaks in the brain's plumbing system, allowing toxic substances to seep into the brain areas responsible for memory encoding and other cognitive functions.

29 Apr 2020

MBI may give important clues about early stages of dementia

In recent years, scientists have conducted more than 100 clinical trials in the hopes of finding new indicators capable of diagnosing Alzheimer's disease prior to the manifestation of clinical symptoms such as memory loss.

8 Apr 2020

Amyloid plaque formation causes brain tissue loss in animals

Amyloid plaque formation directly causes brain tissue loss in animals, but a drug called lithium reduces the life-shortening effects of this loss, shows a study published today in eLife.

31 Mar 2020

Subtle differences in cognitive performance predict progression to Alzheimer's pathology

Alzheimer's disease is progressive, but slow to develop -- or at least to reveal itself. In a new study, published online February 14, 2020 in the journal Biological Psychiatry, researchers at University of California San Diego School of Medicine, with colleagues elsewhere, report that early, subtle differences in cognitive performance, such as fewer words recalled on a memory test, are a sign that harmful proteins are accumulating in the brain, even if levels of those proteins do not yet qualify as dangerous.

16 Feb 2020

Neuronal necrosis occurs much earlier in Alzheimer’s disease progression than previously thought

Alzheimer's remains the leading cause of dementia in Western societies, with some estimates suggesting that as many as 24 million people worldwide are living with the disease.

13 Feb 2020

Flickering light triggers the brain to release signaling chemicals that may help fight Alzheimer's

For over a century, Alzheimer's disease has confounded all attempts to treat it. But in recent years, perplexing experiments using flickering light have shown promise.

4 Feb 2020

Suppressing MSUT2 gene may protect people from Alzheimer’s disease

In the wake of recent disappointments over clinical trials targeting amyloid plaque build-up in Alzheimer's disease, researchers are focusing more attention on misfolded tau protein, another culprit in brain diseases that cause dementia.

18 Dec 2019

Genetic mutation of APOE gene may provide protection against Alzheimer's disease

A team of researchers has identified that a genetic mutation of the APOE gene, the major susceptibility gene for late-onset Alzheimer's disease, may provide protection against the devastating neurological illness.

4 Nov 2019

New findings can redefine the diagnosis of mild cognitive impairment in men and women

Using sex-specific scores on memory tests may change the diagnosis for 20 percent of those currently diagnosed with mild cognitive impairment (MCI), with possibly more women and fewer men being diagnosed with MCI, according to a new study published online in the journal Neurology.

11 Oct 2019

New peptides improve memory in mice with Alzheimer’s

Alzheimer’s disease (AD) affects over 44 million people the world over. But now, neurologist Jack Jhamandas and his team have found two short peptides which, on daily injection into mice with symptoms of AD for just five weeks, led to a significant improvement.

18 Sep 2019

New insight and target for Alzheimer’s disease

The body is designed to fix anything that is out of balance. Homeostasis is maintained in the body, and even a minor change could trigger a compensatory mechanism, in the hopes of keeping everything stable.

4 Sep 2019

"Australian" genetic mutation provides clues to Alzheimer’s mechanism

In an astonishing new breakthrough in Alzheimer’s research, the molecular basis of early-onset Alzheimer’s disease (AD) and age-linked AD has been identified by looking at one type of genetic mutation.

26 Aug 2019

Researchers discover new therapeutic target for treatment of Alzheimer's disease

Experiments performed in mice, in which the main pathogenic markers of the disease have been evaluated, show that the progression of the disease is prevented when the function of this protein is inactivated.

15 Jul 2019

Study offers clues about how to prevent brain inflammation in Alzheimer's

A new study by scientists at Massachusetts General Hospital offers clues about how to prevent inflammation of brain tissue, which promotes Alzheimer's disease

11 Jul 2019

Long-term antibiotic treatment slows growth of amyloid plaques in male mice but not in females

Researchers at The University of Chicago have demonstrated that the type of bacteria living in the gut can influence the development of Alzheimer's disease symptoms in mice.

17 May 2019

Machine learning tool immensely scales up Alzheimer's research

Researchers at UC Davis and UC San Francisco have found a way to teach a computer to precisely detect one of the hallmarks of Alzheimer's disease in human brain tissue, delivering a proof of concept for a machine-learning approach to distinguishing critical markers of the disease.

15 May 2019

Neuroscientists propose new theory about amyloid precursor protein connection in Alzheimer's

Worldwide, 50 million people are living with Alzheimer's disease and other dementias. According to the Alzheimer's Association, every 65 seconds someone in the United States develops this disease, which causes problems with memory, thinking and behavior.

23 Apr 2019

Falling for telephone scams could be an early sign of dementia

The United States Department of Justice says that annually around $3 billion is defrauded from seniors. Many of these tricksters use the telephone for their scams. What would not dupe a person with normal mental faculties often takes in seniors. A new study shows that elderly with mild cognitive impairment or early signs of dementia often fall prey to these telephone scams.

16 Apr 2019