Analgesia News and Research

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Purdue demonstrates efficacy of Butrans transdermal delivery system for chronic pain in opioid-naive patients

Physicians from Purdue Pharma LP, Stamford, CT, showcased study results that demonstrate the analgesic efficacy and safety of Butrans for the relief of moderate to severe chronic low back pain in opioid-naive patients. Butrans is a transdermal delivery system that provides systemic delivery of buprenorphine, a Schedule III medication, continuously over a 7-day period.

25 Mar 2011

Study examines regional analgesia effect on long-term outcomes in soldiers with combat injuries

Little is known about the impact of early aggressive regional analgesia on short- and long-term pain and psychological outcomes of soldiers with major combat injuries.

25 Mar 2011

New findings may make morphine a safer, more effective drug for chronic pain control

An orphan drug originally used for HIV treatment has been found to short-circuit the process that results in additional sensitivity and pain from opioid use. The study by researchers at the Indiana University School of Medicine is reported in the March 25, 2011 issue of Brain, Behavior and Immunity.

25 Mar 2011

Ibuprofen - painkiller toxicity warning

In a recent development, doctors have warned regarding the possibly toxicities of common pain killer Ibuprofen adding that it can lead to a potentially fatal condition which can be triggered, in rare cases, by even a standard dose. The condition in question is called renal tubular acidosis (RTA). The research is published in the Medical Journal of Australia.

21 Mar 2011

U.S. FDA approves Hospira's docetaxel to treat variety of cancers

Hospira, Inc., the world leader in generic injectable pharmaceuticals, today announced U.S. Food and Drug Administration approval of docetaxel. The medication is a generic version of Sanofi-Aventis's Taxotere, and Hospira expects to launch the product later this month.

9 Mar 2011

'Cross-talk' between two major biological pathways may hold a clue for chronic pain treatment

Researchers at the University of California, Davis have discovered a "cross-talk" between two major biological pathways that involve pain-research that may pave the way to new approaches to understanding and controlling chronic pain.

9 Mar 2011

Anesthesia & Analgesia journal receives notification from LÄK for lack of IRB approval in 89 articles

The peer-reviewed medical journal Anesthesia & Analgesia received notification from Landesärztekammer Rheinland-Pfalz, the Rheinland State Medical Board, that there was no IRB approval for 89 articles published Dr. Joachim Boldt, including 22 published by A&A from 1999-2009.

1 Mar 2011

New 'closed-loop' system can provide tightly controlled anesthesia in patients undergoing surgery

A new 'closed-loop' system can precisely adjust levels of anesthetics and analgesic drugs in patients undergoing surgery, reports a study in the March issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

25 Feb 2011

Study: BPS is safe and effective for patients undergoing therapeutic endoscopy

Researchers from Korea report that, compared with conventional sedation, balanced propofol sedation using propofol in combination with midazolam and meperidine, provided higher health care provider satisfaction, better patient cooperation, and similar adverse event profiles in patients undergoing therapeutic endoscopic procedures.

16 Feb 2011

Surgical procedure to repair spina bifida while still in the uterus may help the baby walk after birth

More than two thousand physicians, some of the top obstetric/gynecologists in the world who specialize in maternal-fetal medicine, especially high risk pregnancies, gathered today for their annual meeting in San Francisco to begin four days of intensive research presentations. Presentations each year at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting -, represent major findings in reducing high-risk pregnancies and complications.

11 Feb 2011

AcelRx prices initial public offering at $5.00 per share

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of acute and breakthrough pain, today announced the pricing of its initial public offering of 8 million shares of common stock at $5.00 per share. All of the common stock will be sold by AcelRx.

11 Feb 2011

Mallinckrodt receives FDA approval for Fentanyl Transdermal System patch ANDA

Covidien, a leading global provider of healthcare products, today announced that Mallinckrodt Inc., a Covidien company, has received U.S. Food and Drug Administration (FDA) approval of its Abbreviated New Drug Application (ANDA) for its Fentanyl Transdermal System (FTS) patch. Covidien is the largest supplier of controlled pain medications in the United States based on number of prescriptions.

10 Feb 2011

Women use less of self-administered analgesic during labor

In a study to be presented today at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting -, in San Francisco, researchers will present findings that show that when women administer their own patient-controlled epidural analgesia (PCEA) instead of getting a continuous epidural infusion (CEI) they used less analgesic, but reported similar levels of satisfaction.

10 Feb 2011

Critical care journal editors release joint statement affirming commitment to ethical conduct of research

In response to an announcement by the German State Medical Association of Rheinland-Pfalz of their initial review of more than 100 articles by Professor Joachim Boldt, Steven L. Shafer, MD, Editor-in-Chief of Anesthesia & Analgesia, has joined with ten other anesthesiology and critical care journal editors in releasing a joint statement affirming their commitment to ethical conduct of research.

5 Feb 2011

Pacira prices initial public offering at $7.00 per share

Pacira Pharmaceuticals, Inc., an emerging specialty pharmaceutical company, today announced the pricing of its initial public offering of 6,000,000 shares of its common stock at $7.00 per share, before underwriting discounts and commissions.

4 Feb 2011

FDA approves Hospira's topotecan for SCLC

Hospira, Inc., the world leader in generic injectable pharmaceuticals, today announced U.S. Food and Drug Administration (FDA) approval of Topotecan Injection, the first solution formulation of the oncology drug approved in the United States.

3 Feb 2011

DARA BioSciences' KRN5500 Phase 2 study in advanced cancer selected for presentation at ADEPT 2011

The Company announced that the University of Rochester in concert with ADEPT has selected the study results from the KRN5500 Phase 2 study to be presented at its March 25-26, 2011 conference. The presentation is entitled, "Management of Placebo Response in a Randomized Trial of KRN5500 in Patients with Neuropathic Pain and Cancer."

2 Feb 2011

Etanercept can restore responsiveness to pain-relieving effects of morphine: Study

A drug called etanercept can restore responsiveness to the pain-relieving effects of morphine in rats that have developed morphine tolerance, reports a study in the February issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

29 Jan 2011

Nitrous oxide anesthesia may lead to increased risk of myocardial infarction: Study

Patients receiving nitrous oxide as part of general anesthesia for surgery may be at increased long-term risk of myocardial infarction (heart attack), reports a study in the February issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

29 Jan 2011

Phase III study affirms safety and efficacy of Cumberland's Caldolor for post-operative pain

Cumberland Pharmaceuticals Inc. today announced the publication of data affirming the safety and efficacy of Caldolor® (ibuprofen) Injection in treating post-operative pain in hospitalized patients. A Phase III study published in the peer-reviewed journal Pain Practice concluded that IV ibuprofen significantly reduced both morphine use and self-reported pain intensity in patients recovering from abdominal hysterectomy compared to morphine alone.

27 Jan 2011

Analgesia News and Research

Purdue demonstrates efficacy of Butrans transdermal delivery system for chronic pain in opioid-naive patients

Study examines regional analgesia effect on long-term outcomes in soldiers with combat injuries

New findings may make morphine a safer, more effective drug for chronic pain control

Ibuprofen - painkiller toxicity warning

U.S. FDA approves Hospira's docetaxel to treat variety of cancers

'Cross-talk' between two major biological pathways may hold a clue for chronic pain treatment

Anesthesia & Analgesia journal receives notification from LÄK for lack of IRB approval in 89 articles

New 'closed-loop' system can provide tightly controlled anesthesia in patients undergoing surgery

Study: BPS is safe and effective for patients undergoing therapeutic endoscopy

Surgical procedure to repair spina bifida while still in the uterus may help the baby walk after birth

AcelRx prices initial public offering at $5.00 per share

Mallinckrodt receives FDA approval for Fentanyl Transdermal System patch ANDA

Women use less of self-administered analgesic during labor

Critical care journal editors release joint statement affirming commitment to ethical conduct of research

Pacira prices initial public offering at $7.00 per share

FDA approves Hospira's topotecan for SCLC

DARA BioSciences' KRN5500 Phase 2 study in advanced cancer selected for presentation at ADEPT 2011

Etanercept can restore responsiveness to pain-relieving effects of morphine: Study

Nitrous oxide anesthesia may lead to increased risk of myocardial infarction: Study

Phase III study affirms safety and efficacy of Cumberland's Caldolor for post-operative pain

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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