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Study reveals nerve changes linked to pain and urinary frequency in recurrent UTI sufferers

How sensory nerve sprouting and mast cell activity, driven by nerve growth factor (NGF), contribute to persistent bladder pain and dysfunction in recurrent urinary tract infection (rUTI) cases.

7 Mar 2024

Scientists design breakthrough drug to combat deadly pancreatic cancer mutation

Scientists discover a new way to disarm a deadly protein that also appears in cancers of the lung, breast and colon.

5 Mar 2024

UCSF scientists discover less invasive prenatal treatment for Angelman syndrome

In a discovery that opens the door to a less invasive way of treating some serious disorders before birth, UC San Francisco scientists have found that delivering medicine through amniotic fluid is as effective as delivering it to the fetal brain via cerebrospinal fluid.

4 Mar 2024

Study demonstrates the deleterious effects of chronic cocaine use on functional brain networks

A collaborative research endeavor by scientists in the Departments of Radiology, Neurology, and Psychology and Neuroscience at the UNC School of Medicine have demonstrated the deleterious effects of chronic cocaine use on the functional networks in the brain.

28 Feb 2024

Machine learning unveils key molecular players and immune signatures in stress cardiomyopathy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Stress cardiomyopathy (SCM) is a reversible, self-limiting condition that manifests as left ventricular insufficiency.

28 Feb 2024

UMass Amherst study targets aplastic anemia with cell retraining approach

Researchers at the University of Massachusetts Amherst recently released a first-of-its-kind study that focuses on the rare autoimmune disorder aplastic anemia to understand how a subset of cells might be trained to correct the overzealous immune response that can lead to fatal autoimmune disorders.

27 Feb 2024

UMSOM wins $3.5 million BARDA contract to develop animals models for radiation research

University of Maryland School of Medicine Dean Mark T. Gladwin, MD, announced today that UMSOM faculty scientists have been selected as key contractors by the Biomedical Advanced Research and Development Authority (BARDA), for the federal agency's Radiation Nuclear Animal Model Development program.

26 Feb 2024

Collaborative project gets $20 million to develop new radiopharmaceutical cancer therapies

UT Health Science Center researchers Gabor Tigyi, MD, PhD, Harriet Van Vleet Endowment Professor in Basic Oncology Research, Junming Yue, PhD, associate professor in the Department of Pathology, Sue Chin Lee, PhD, in the Department of Physiology, and David Schwartz, MD, chair of the Department of Radiation Oncology, are part of a scientific leadership group awarded $20 million from the University of Tennessee-Oak Ridge Innovation Institute in partnership with Oak Ridge National Laboratory and the University of Tennessee, Knoxville, to develop new radiopharmaceutical therapies to treat cancer.

21 Feb 2024

Study links ultra-processed food consumption with higher cardiovascular risk

Systematic review and meta-analysis revealed a linear relationship between the consumption of ultra-processed foods and an increased risk of cardiovascular events, emphasizing the need for public health initiatives to mitigate this risk.

21 Feb 2024

Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

Although it is one of the oldest medications used to treat patients with inflammatory bowel disease (IBD) and an effective treatment for an associated arthritis condition called spondyloarthritis (SpA), sulfasalazine's mechanism of action has been unclear.

20 Feb 2024

Breaking through new research barriers with iPSC technology

In this interview, we speak to Keith Olson and Coby Carlson from Fujifilm Cellular Dynamics about their iPSC technology.

From FUJIFILM Cellular Dynamics 15 Feb 2024

MIT researchers develop new test for ventricular assist device suitability

Every year, around 50,000 people in the United States experience cardiogenic shock -; a life-threatening condition, usually caused by a severe heart attack, in which the heart can't pump enough blood for the body's needs.

14 Feb 2024

Researchers develop groundbreaking technique to detect chemoresistance using ultrasound

Researchers at Purdue University have developed a technique to better predict chemotherapy resistance in canines and humans.

13 Feb 2024

Gene therapy reverses advanced heart failure in animal study

Heart failure remains the leading cause of mortality in the U.S. During a heart attack blood stops flowing into the heart.

13 Feb 2024

Blood biomarkers in TGF-β pathway identify hidden liver cancer risk

A new research paper was published in Genes & Cancer on February 5, 2023, entitled, "Mechanistically based blood proteomic markers in the TGF-β pathway stratify risk of hepatocellular cancer in patients with cirrhosis."

9 Feb 2024

CN Bio appoints Joseph Parisi as US Director of Sales to support accelerated growth in key OOC market

CN Bio, a leading Organ-on-a-Chip (OOC) company that designs and manufactures single- and multi-organ microphysiological systems (MPS), today announced the appointment of Joseph Parisi as US Director of Sales. In his new role, Joe will lead the expansion of the Company’s sales and support activities for the US market to address the growing demand for new alternative methodologies (NAMs) in preclinical drug discovery.

31 Jan 2024

Gene therapy could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy

A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of dangerous irregular heartbeats.

30 Jan 2024

Prior exposure to common cold coronaviruses can train T cells to fight SARS-CoV-2

Scientists at La Jolla Institute for Immunology (LJI) have found direct evidence that exposure to common cold coronaviruses can train T cells to fight SARS-CoV-2. In fact, prior exposure to a common cold coronavirus appears to partially protect mice from lung damage during a subsequent SARS-CoV-2 infection.

27 Jan 2024

New study of daylight vision using canine model offers critical insight into restoring cone function

In the retinas of human eyes, the cones are photoreceptor cells responsible for color vision, daylight vision, and the perception of small details.

27 Jan 2024

Low-dose radiation shows promise as treatment for brain injury and stroke

Traumatic brain injury (TBI) and ischemic stroke are major public health concerns and leading causes of death and disability worldwide.

27 Jan 2024

Animal Model News and Research

Study reveals nerve changes linked to pain and urinary frequency in recurrent UTI sufferers

Scientists design breakthrough drug to combat deadly pancreatic cancer mutation

UCSF scientists discover less invasive prenatal treatment for Angelman syndrome

Study demonstrates the deleterious effects of chronic cocaine use on functional brain networks

Machine learning unveils key molecular players and immune signatures in stress cardiomyopathy

UMass Amherst study targets aplastic anemia with cell retraining approach

UMSOM wins $3.5 million BARDA contract to develop animals models for radiation research

Collaborative project gets $20 million to develop new radiopharmaceutical cancer therapies

Study links ultra-processed food consumption with higher cardiovascular risk

Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

Breaking through new research barriers with iPSC technology

MIT researchers develop new test for ventricular assist device suitability

Researchers develop groundbreaking technique to detect chemoresistance using ultrasound

Gene therapy reverses advanced heart failure in animal study

Blood biomarkers in TGF-β pathway identify hidden liver cancer risk

CN Bio appoints Joseph Parisi as US Director of Sales to support accelerated growth in key OOC market

Gene therapy could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy

Prior exposure to common cold coronaviruses can train T cells to fight SARS-CoV-2

New study of daylight vision using canine model offers critical insight into restoring cone function

Low-dose radiation shows promise as treatment for brain injury and stroke

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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