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Fetal and neonatal therapy combination may lessen the aftereffects of congenital CMV infection

A cross-institutional research group has revealed for the first time in the world that infants with symptomatic congenital cytomegalovirus (CMV) infection who were treated with a combination of immunoglobulin fetal therapy and neonatal therapy with antiviral drugs were less likely to experience the severe aftereffects associated with the infection than those who only received the neonatal therapy.

28 Jan 2021

Variants emerging during COVID-19 pandemic resist antibody neutralization

Researchers in the U.S. have warned that recently emerged variants of SARS-CoV-2 have become worryingly resistant to monoclonal antibody therapies, plasma from convalescent patients and sera from vaccinated individuals.

28 Jan 2021

Can the US keep covid variants in check? Here’s what it takes

The covid-19 variants that have emerged in the United Kingdom, Brazil, South Africa and now Southern California are eliciting two notably distinct responses from U.S. public health officials.

28 Jan 2021

Moderna vaccine shows robust suppression of SARS-CoV-2 infection in animal model

Researchers have demonstrated that the prime or prime-boost vaccination of Moderna vaccine in hamsters induced robust neutralizing antibodies, ameliorated weight loss, and suppressed SARS-CoV-2 replication in the airways.

28 Jan 2021

Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2

Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2, preventing expression of genes that encode proteins in cells such as resident macrophages in the nose and pulmonary alveoli, and epithelial cells lining the alveoli, all of which are entry points for the virus.

28 Jan 2021

Ebola survivors experienced a resurgence in antibody levels after recovery

A high proportion of survivors of Ebola experienced a resurgence in antibody levels nearly a year after recovery, a new University of Liverpool study has found.

27 Jan 2021

Study uncovers a novel promising target for diabetes treatment

Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The latest study from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes Research is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery.

27 Jan 2021

Biliverdin shields SARS-CoV-2 from host antibody response, study finds

A team of international scientists has recently revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with two heme metabolites, bilirubin and biliverdin, to escape the antibody-mediated host immune responses.

27 Jan 2021

If I have cancer, dementia or MS, should i get the covid vaccine?

As public demand grows for limited supplies of covid-19 vaccines, questions remain about the vaccines' appropriateness for older adults with various illnesses.

27 Jan 2021

What do we know about the SARS-CoV-2 vaccines so far?

A new study surveys what we know so far about SARS-CoV-2 vaccine candidates from advanced clinical trials.

27 Jan 2021

SARS-CoV-2 spike may impair antigen presentation by CD8 T cells

A new study published on the bioRxiv preprint server aims to identify specific viral epitopes on the spike protein from various regions of the spike protein and the T cell responses they evoke.

27 Jan 2021

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

Now, in new research posted to the preprint server bioRxiv*, scientists use an experimental structure of the Spike RBD domain co-crystallized with part of the ACE2 receptor and several in silico methods to analyze the possible impacts of three amino acid replacements (Spike K417N, E484K, N501Y) concerning ACE2 binding.

27 Jan 2021

Pain-free microneedle patch can capture biomarkers from interstitial fluid

Blood draws are no fun. They hurt. Veins can burst, or even roll -; like they're trying to avoid the needle too, Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and sepsis.

26 Jan 2021

Mutations in the SARS-CoV-2 receptor-binding domain analyzed

Using more than 100,000 virus genome sequences uploaded in the GISAID database, researchers found around 9,000 mutations in the virus spike protein RBD.

26 Jan 2021

Antibodies and inflammatory markers may help identify COVID-19 cases and predict severity

A new preprint appearing on the medRxiv server describes the changes that occur in numerous antibodies and inflammatory molecules with age and at varying stages, or severity, of the infection and resulting illness. The results may help to predict the risk in individual cases.

26 Jan 2021

Elevated levels of certain immune cells in the blood linked to COVID-19 severity

Individual variations in how the immune system responds to SARS-CoV-2 appear to impact the severity of disease.

26 Jan 2021

Moderna vaccine fully neutralizes new SARS-CoV-2 variants, study shows

Researchers in the United States have conducted a study showing that Moderna’s mRNA-1273 vaccine neutralizes all circulating variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tested to date.

26 Jan 2021

Single-dose universal vaccine could protect against leptospirosis bacteria

Scientists have designed a single-dose universal vaccine that could protect against the many forms of leptospirosis bacteria, according to a study published today in eLife.

26 Jan 2021

New approach to mapping viral mutations that escape antibodies used to treat COVID-19

A new approach to mapping viral mutations that "escape" leading clinical antibodies has revealed mutations in the SARS-CoV-2 virus that allow it to evade treatments, including a single amino-acid mutation that fully escapes Regeneron's antibody cocktail.

26 Jan 2021

New discovery could lead to faster and more effective treatments for chronic health complications

A world-first discovery by researchers at Monash University and The University of Queensland could lead to faster and more effective treatments for chronic health complications, such as cardiovascular disease and cancer, with 'fluorescent' in vivo biosensors.

26 Jan 2021