Antibodies News and Research

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No evidence for risk of vaccine-driven virulence evolution in SARS-CoV-2

Beyond the morbidity and mortality associated with the pandemic, COVID-19 has paralyzed the global economy.

7 Dec 2020

High-performance ELISA for serology in mild-moderate non-hospitalized COVID-19

A new study describes an ELISA assay that combines the detection of IgM, IgA, and IgG antibodies against the SARS−CoV−2 trimeric spike glycoprotein.

7 Dec 2020

Novel modular design approach to antibody nanocage generation

A new study shows the benefits of using computational design to create antibody nanocages that have the required orientation.

7 Dec 2020

New biomarker of Alzheimer's may lead to enhanced diagnostic methods

Scientists at Washington University School of Medicine, Missouri, have identified a novel form of an Alzheimer’s protein in the spinal fluid of patients.

7 Dec 2020

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clinical investigators from Hackensack Meridian Health John Theurer Cancer Center (JTCC), a member of the Georgetown Lombardi Comprehensive Cancer Center consortium, are to present updates on treatment advances in multiple myeloma (MM), mantle cell lymphoma (MCL), and other types of B-cell lymphoma (BCL) as well as leukemia at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held virtually from December 5-8, 2020.

7 Dec 2020

Researchers shed light on the role of antibodies and immune cells in protection against COVID-19

Since the novel coronavirus emerged at the end of last year, scientists around the world -- including Beth Israel Deaconess Medical Center (BIDMC) immunologist Dan Barouch, MD, PhD -- have been developing vaccines to protect against COVID-19 and to put an end to the global pandemic.

5 Dec 2020

COVID-19 herd immunity threshold far higher than previously thought, say researchers

Researchers in the US have re-analyzed the data on herd immunity from spring 2020 from Europe. Their study shows that the herd immunity threshold is much higher than earlier speculated.

4 Dec 2020

Sensitivity of coronavirus antibody tests may be lower than stated on the package

A study by University of Tartu researchers indicates that the sensitivity of tests used to detect viral antibodies in a blood sample may differ significantly. The combination of several tests may give the best result.

3 Dec 2020

TTUHSC professor receives 2020 Lupus Mechanisms and Targets Award

The Lupus Research Alliance recently named R. Bryan Sutton, Ph.D., a professor in the Department of Cell Physiology and Molecular Biophysics at the Texas Tech University Health Sciences Center, as a recipient of a 2020 Lupus Mechanisms and Targets Award.

3 Dec 2020

High seroprevalence of short-lived anti-SARS-CoV-2 antibodies in Paris

A recent study indicates a high seroprevalence of antibodies against SARS-CoV-2 among individuals working in a Paris-based institute.

3 Dec 2020

Designed proteins assemble antibodies into modular nanocages

With cues from nature, designing functional molecules enables scientists to nanoengineer and customize for specific uses.

3 Dec 2020

Nanoparticles with neutralizing antibodies can inactivate SARS-CoV-2

Using nanoparticles conjugated with SARS-CoV-2 neutralizing antibodies, researchers demonstrated that intense local heating could inactivate the virus.

3 Dec 2020

COVID-19 mutation mapping identifies escape mutations against therapeutic antibodies

A new study maps all known mutations in the SARS-CoV-2 virus, showing how each contributes to escape from individual antibodies.

3 Dec 2020

Novel “multitope” vaccine shows promise in the fight against COVID-19

Researchers have demonstrated the potential of a protein-peptide vaccine to protect against infection with SARS-CoV-2, the agent that causes COVID-19.

3 Dec 2020

The UK approves Pfizer vaccine for December 2020 roll out

The UK approves Pfizer vaccine and schedules phased vaccination process, commencing December 2020.

2 Dec 2020

SARS-CoV-2 D614G mutation does not affect performance of serological assays

In a new study published in The Journal of Infectious Diseases, US researchers considered the emergence of a new SARS-CoV-2 spike protein variant. They compared spike G614-based assay to the original D614-based assay – pointing towards the development of recognizable, cross-responsive humoral immunity.

2 Dec 2020

A new potential COVID-19 vaccine candidate: YF-S0

A recent study published in the journal Nature describes the safety and efficacy of a live-attenuated yellow fever 17D (YF17D) vector-based vaccine candidate expressing a non-cleavable form of the spike protein of severe acute respiratory coronavirus 2 (SARS-CoV2).

2 Dec 2020

SARS-CoV-2 deletion mutations may have attenuated infectivity in some strains

A team of researchers at the University of Hong Kong has identified a panel of SARS-CoV-2 variants, called Del-mut, which contains a deletion in the S1/S2 junction. Upon investigating one of the deleted variants in animal models, they found that Del-mut-1 is attenuated in its ability to cause disease or pathological changes.

2 Dec 2020