Antidepressant News and Research

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Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They can improve your mood, sleep, appetite and concentration. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try several before finding what works best for you.

Citalopram no more effective than a placebo for children with autism spectrum disorders

Citalopram, a medication commonly prescribed to children with autism spectrum disorders (ASD), was no more effective than a placebo at reducing repetitive behaviors, according to researchers funded by the National Institute of Mental Health (NIMH) and other NIH institutes. The study was published in the June 2009 issue of Archives of General Psychiatry.

1 Jun 2009

Popular antidepressants taken with tamoxifen can increase the risk of breast cancer recurrence

A new study found that taking tamoxifen with certain antidepressants more than doubled the risk of breast cancer recurrence in women taking both medications. The antidepressants inhibit an enzyme, CYP2D6, which helps tamoxifen work effectively.

1 Jun 2009

Treating pain with depression

Pain, the most common reason for adults to visit a primary care physician, and depression, the most frequent mental complaint requiring a doctor's appointment, occur together as often as half the time.

26 May 2009

Comparative effectiveness necessary to weigh new drugs against old ones, opinion piece says

Patients and physicians "need to know not just whether a new drug outperforms a placebo, but whether it's a real advance on what's already on the market," Richard Friedman, a professor of psychiatry at Weill Cornell Medical College, writes in a New York Times opinion piece.

20 May 2009

Pregabalin shows potential as treatment for hot flashes

A pill used for nerve pain offers women relief from hot flashes, Mayo Clinic researchers report at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO).

17 May 2009

Participants in antidepressant drug trials are atypical patients

One reason antidepressant medication treatments do not work as well in real life as they do in clinical studies could be the limited type of study participants selected, researchers at UT Southwestern Medical Center have found.

12 May 2009

New antidepressants might be no more effective than the best existing drugs

The reviews suggest that sertraline - sold under the brand name Zoloft since 1991- could be the best initial choice of antidepressant in people with acute major depression. The generic formulation produced the best balance of effectiveness, tolerability and purchase price, the authors say.

5 May 2009

New target for the treatment of depression

An acid-sensitive protein in the brain may represent a new target for the treatment of depression, according to animal research in the April 29 issue of The Journal of Neuroscience.

30 Apr 2009

Are we cherry picking participants for studies of antidepressants?

Findings from clinical studies used to gain Food and Drug Administration approval of common antidepressants are not applicable to most patients with depression, according to a report led by the University of Pittsburgh Graduate School of Public Health.

30 Apr 2009

Children as young as five with life threatening anorexia

New research by Australian experts has revealed that children as young as five are being treated for eating disorders - the researchers say in some cases the eating disorder has reached the stage that forced feeding becomes necessary in order to save their lives.

20 Apr 2009

Depression after heart disease increases risk of heart failure

Patients with heart disease who are subsequently diagnosed with depression are at greater risk for heart failure (HF), a condition in which the heart can't pump enough blood throughout the body, according to a new study published in the April 21, 2009, issue of the Journal of the American College of Cardiology.

13 Apr 2009

Smokers with serious illnesses need additional help to quit, study says

Individuals with serious illnesses - including cancer, heart disease and chronic obstructive pulmonary disease - make up a disproportionately high segment of current smokers and are also among the most addicted to tobacco use.

8 Apr 2009

Cost-cutting measures are creeping into the medicine cabinet

Cost-cutting measures are creeping into the medicine cabinet. We split pills in half or take the drugs every other day to stretch our doses. We stop filling the prescriptions for our most expensive drugs. We buy prescriptions from online pharmacies with questionable credentials.

6 Apr 2009

How men and women cope differently with stress traced to genetic differences

Can people's differing reactions to situations of stress be attributed at least in part to genetic differences and do those differences affect men and women in different ways - with the edge seemingly favoring the women? Research conducted at the Hebrew University of Jerusalem would seem to indicate that the answer to both questions is yes.

5 Apr 2009

p11 protein may lead to faster acting antidepressants

Research conducted by Nobel laureate Paul Greengard, Medical Director of The Michael Stern Parkinson's Research Center at The Rockefeller University, Dr. Jennifer L. Warner-Schmidt in New York and colleagues in Sweden, demonstrated in the Journal of Neuroscience that the brain protein called p11 could lead pharmaceutical companies to develop anti-depression drugs that begin working within hours or days rather than the weeks or even months required by current drugs.

23 Mar 2009

FDA approves Symbyax for treatment-resistant depression

The U.S. Food and Drug Administration (FDA) has approved a new indication for Symbyax (olanzapine and fluoxetine HCl capsules), Eli Lilly and Company has announced.

23 Mar 2009

New JAMA policy says whistle-blowers should stay silent while conflict-of-interest investigations are ongoing

The Journal of the American Medical Association has announced that it will instruct anyone filing a complaint about potential conflicts of interest of a study author to refrain from contacting third parties or the media about the allegation until the journal investigates the matter, the Wall Street Journal reports.

23 Mar 2009

Nationwide alert on tainted weight loss products

The U.S. Food and Drug Administration is expanding, for the second time, its nationwide alert to consumers about tainted weight loss products containing

22 Mar 2009

Salt could be 'nature's antidepressant' according to new research

Most people consume far too much salt, and a University of Iowa researcher has discovered one potential reason we crave it: it might put us in a better mood.

11 Mar 2009

Relationship between depressive symptoms and cardiac events

New data published in the March 17, 2009, issue of the Journal of the American College of Cardiology suggest that relatively healthy women with severe depression are at increased risk of cardiac events, including sudden cardiac death (SCD) and fatal coronary heart disease (CHD).

10 Mar 2009