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Scientists uncover key to enhancing cancer-killing T cells

T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known as exhaustion.

21 Nov 2023

Breakthrough in HIV treatment: NMN shows promise in reducing CD4+ T cell activation

The impact of nicotinamide mononucleotide (NMN) on Clusters of differentiation 4+ (CD4+ ) Thymus cells (T cells) viz.

21 Nov 2023

Avian influenza A H5N1 virus impacts wide range of wildlife in the U.S., study shows

Study highlights the spread of the highly pathogenic avian influenza A (H5N1) virus among non-domesticated animals in the U.S., revealing neurological symptoms as a key clinical presentation and expanding the range of species affected by this Eurasian lineage virus.

19 Nov 2023

Unraveling the immune system's response to nanoparticle drug delivery

To reduce the side effects associated with chemotherapy treatments, researchers have investigated the use of delivery systems that can take more drugs directly to the tumor. Ninh (Irene) La-Beck, Pharm.D., from the Department of Immunotherapeutics and Biotechnology at the Texas Tech University Health Sciences Center (TTUHSC) Jerry H. Hodge School of Pharmacy is one of those researchers.

17 Nov 2023

Assessing DDX53 as a potential early esophageal cancer antigen

A new research paper was published in Oncoscience (Volume 10) on November 10, 2023, entitled, "An immunoinformatics assessment of the cancer testis antigen, DDX53, as a potential early esophageal cancer antigen."

17 Nov 2023

Photobiomodulation in Alzheimer's mouse model falls short in preventive impact

Study assesses the effectiveness of photobiomodulation (PBM) treatment in a mouse model of Alzheimer's disease and finds no significant impact on behavioral performance or neurodegeneration, suggesting the need for further research into PBM's therapeutic potential.

16 Nov 2023

B-BiTE modality enhances anti-myeloma effects of clinically available antibodies

Multiple myeloma still appears to be an incurable hematological malignancy. One of the reasons is that myeloma cells can be heterogenous and acquire resistance after anti-myeloma treatment.

16 Nov 2023

Gene splicing determines CD20 levels and response to monoclonal antibody therapy

Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated.

16 Nov 2023

Exploring the dual role of nirmatrelvir and bisphosphonates in COVID-19 treatment and immunity

Review examines nirmatrelvir and bisphosphonates in treating COVID-19, revealing their impact on SARS-CoV-2-specific adaptive immunity and potential to mitigate severe infections, highlighting the need for balanced long-term immunity management.

16 Nov 2023

One in five patients on Nirmatrelvir–Ritonavir experience virologic rebound, new observational study reveals

The frequency of viral rebound (VR) among acute coronavirus disease 2019 patients.

16 Nov 2023

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Study reveals that senolytics can reduce aging in human brain organoids and mitigate COVID-19 neuropathology, suggesting their potential as a therapeutic strategy against brain aging and coronavirus-related neurological complications.

15 Nov 2023

New lipidic peptide IK14004 shows promise in treating cancer and reducing autoimmune complications

A lipidic peptide, named IK14004.

15 Nov 2023

New approach to CAR T cell therapy may extend treatment effectiveness

CAR T cell therapy, a powerful type of immunotherapy, has begun to revolutionize cancer treatment. Pioneered at Memorial Sloan Kettering Cancer Center (MSK), the therapy involves engineering a patient's T cells so they recognize and attack cancer cells.

14 Nov 2023

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Researchers in Purdue University's College of Pharmacy are leveraging the dual roles played by an enzyme found in both cancer cells and T cells to create a novel cancer immunotherapy compound.

14 Nov 2023

Unlocking the cure for hepatitis B virus: Challenges and opportunities

Hepatitis B virus (HBV) is a significant public health problem, with over 296 million people chronically infected worldwide.

13 Nov 2023

Study sheds light on role of antibodies in vaccine protection against COVID-19 variants

Efforts to contain the Covid-19 pandemic have largely focused on vaccine development and deployment. But how exactly do our immune systems respond to COVID-19 vaccines?

13 Nov 2023

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

A prospective path for allogeneic cellular immunotherapies.

13 Nov 2023

Multi-ancestry study reveals 187 new genetic risk factors for prostate cancer

In a comprehensive multi-ancestry GWAS meta-analysis, researchers identified 451 risk variants for prostate cancer, including 187 new variants, demonstrating the utility of such studies across diverse populations. This analysis not only increased understanding of genetic risk factors but also differentiated between aggressive and non-aggressive prostate cancer types, underscoring the potential of genetic risk scoring in guiding screening and early detection strategies.

12 Nov 2023

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

12 Nov 2023

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Some individuals with anti-Ro/SSA antibodies (anti–Sjögren's-syndrome–related antigen A autoantibodies, also called anti-Ro antibodies) have autoimmune diseases such as lupus or Sjögren's syndrome, but many have no symptoms.

10 Nov 2023

Antigen News and Research

Scientists uncover key to enhancing cancer-killing T cells

Breakthrough in HIV treatment: NMN shows promise in reducing CD4+ T cell activation

Avian influenza A H5N1 virus impacts wide range of wildlife in the U.S., study shows

Unraveling the immune system's response to nanoparticle drug delivery

Assessing DDX53 as a potential early esophageal cancer antigen

Photobiomodulation in Alzheimer's mouse model falls short in preventive impact

B-BiTE modality enhances anti-myeloma effects of clinically available antibodies

Gene splicing determines CD20 levels and response to monoclonal antibody therapy

Exploring the dual role of nirmatrelvir and bisphosphonates in COVID-19 treatment and immunity

One in five patients on Nirmatrelvir–Ritonavir experience virologic rebound, new observational study reveals

Senolytics show promise in combating brain aging and COVID-19 neuropathology

New lipidic peptide IK14004 shows promise in treating cancer and reducing autoimmune complications

New approach to CAR T cell therapy may extend treatment effectiveness

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Unlocking the cure for hepatitis B virus: Challenges and opportunities

Study sheds light on role of antibodies in vaccine protection against COVID-19 variants

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

Multi-ancestry study reveals 187 new genetic risk factors for prostate cancer

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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