Antigen News and Research

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New dual CAR T cell immunotherapy shows enhanced therapeutic potency to fight HIV

A recent study published in the journal Nature Medicine, led by researchers Todd Allen, PhD, a professor of Medicine at Harvard Medical School and group leader at the Ragon Institute of MGH, MIT and Harvard, and Jim Riley, PhD, a professor of Microbiology in the Perelman School of Medicine at the University of Pennsylvania, describes a new Dual CAR T cell immunotherapy that can help fight HIV infection.

31 Aug 2020

Using SARS-CoV-2 epitope to construct a vaccine

A new study published on the preprint server bioRxiv* in August 2020 reports the use of prediction and advanced simulation techniques to identify a novel T cell epitope on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could serve as the basis for a customized vaccine with broad-based efficacy.

30 Aug 2020

Republican Convention, Day 4: Fireworks … and shining a light on Trump’s claims

President Donald Trump accepted the Republican Party's nomination for president in a 70-minute speech from the South Lawn of the White House on Thursday night.

28 Aug 2020

Researchers develop advanced imaging technique to visualize effects of valencies on B cell responses

Designing a vaccine starts with finding the right ingredients. Every infectious agent has molecules, called antigens, that the immune system could potentially recognize and attack. So scientists must carefully consider which antigens should go into a vaccine.

28 Aug 2020

FDA continues to take action in the ongoing response to COVID-19 pandemic

The U.S. Food and Drug Administration (FDA) today continued to take action in the ongoing response to the COVID-19 pandemic

28 Aug 2020

FDA grants Abbott's COVID-19 rapid antigen test emergency-use authorization

Now, the U.S. Food and Drug Administration has granted emergency-use authorization to Abbott Laboratories for a $5 rapid-response COVID-19 antigen test, called BinaxNOW COVID-19 Ag Card, which is roughly the size of a credit card.

27 Aug 2020

Evidence of SARS-CoV-2 coronavirus particles in heart tissue

Researchers in Milan, Italy, have identified the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the heart tissue of deceased coronavirus disease 2019 (COVID-19) patients who had died from respiratory failure, without showing any signs of cardiac involvement.

27 Aug 2020

Pence praises Trump’s ‘seamless’ COVID response, leaves out his state feuds

Vice President Mike Pence portrayed his boss, President Donald Trump, as a leader who has reached out across the aisle to help during the coronavirus pandemic.

27 Aug 2020

New COVID-19 antigen test can be directly read from the testing card

Today, the U.S. Food and Drug Administration issued an emergency use authorization for the first antigen test where results can be read directly from the testing card, a similar design to some pregnancy tests.

27 Aug 2020

UKRI funding could initiate clinical trial for Cambridge-developed DNA vaccine against SARS-CoV-2

A Cambridge-developed DNA vaccine candidate against SARS-CoV-2 could begin clinical trials in the UK in late autumn or early next year, thanks to a £1.9 million award from the UK government.

27 Aug 2020

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

The COVID-19 pandemic is still creating economic and health-related impact over the world. A new study published on the preprint server bioRxiv in August 2020 shows that a gp96-Ig-secreting vaccine candidate based on the expression of full-length spike protein generates a potent T cell response.

26 Aug 2020

Monoclonal antibodies may be a better choice than convalescent plasma for treating COVID-19

A team of researchers from the Netherlands demonstrated that prophylactic treatment with a high dose of human convalescent plasma or by using concentrated monoclonal antibodies could protect against disease following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in an animal model. However, no protective effect was observed with a ten-fold lower dose of convalescent plasma. The results are currently available on the bioRxiv* preprint server.

25 Aug 2020

Preclinical studies of a COVID-19 vaccine candidate show positive results

Preclinical studies of a COVID-19 vaccine candidate at the University of Alabama at Birmingham show positive results that appear to distinguish this vaccine candidate from other vaccine candidates that are currently in advanced stages of clinical development, the Maryland-based Altimmune Inc. announced today.

25 Aug 2020

Allowing low-level CMV infection may boost immunity in stem cell transplant recipients

Patients who develop cytomegalovirus infections after allogeneic stem cell transplantation may be able to develop an immunity against the virus, strengthen their immune system and reduce reliance on strong antiviral medications, a team of cellular-therapy specialists from Roswell Park Comprehensive Cancer Center has found.

25 Aug 2020

Study reveals protective potential of all three major immunoglobulin isotypes against SARS-CoV-2

In a recent medRxiv preprint paper, researchers from Mount Sinai in New York showed that all three major immunoglobulin isotypes (IgM, IgG, and IgA) produced by our immune cells were capable of mediating neutralization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, neutralization titers correlated much better with binding levels of IgM and IgA1 than IgG.

24 Aug 2020

Lasting nature of IBD linked to a long-lived immune cell that provokes damaging inflammation

Inflammatory bowel disease (IBD) is a group of intestinal disorders affecting an estimated six to eight million people worldwide.

24 Aug 2020

New cancer vaccine is predicted to be more effective in human trials

Jefferson researchers developing a cancer vaccine to prevent recurrences of gastric, pancreatic, esophageal and colon cancers have added a component that would make the vaccine more effective.

24 Aug 2020

Trump is sending fast, cheap COVID tests to nursing homes — but there’s a hitch

The Trump administration's latest effort to use COVID-19 rapid tests — touted by one senior official as a "turning point" in arresting the coronavirus's spread within nursing homes — is running into roadblocks likely to limit how widely they'll be used.

24 Aug 2020

Bio-Helix announces approved patent for ECL

Bio-Helix is pleased to be notified of the approved patent application for its proprietary enhanced chemiluminescent substrates (ECL).

24 Aug 2020

Raccoon dogs potential intermediate host for SARS-CoV-2

Researchers at the Friedrich Loeffler Institute in Germany have conducted a study demonstrating that raccoon dogs were a potential intermediate host in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

23 Aug 2020

Antigen News and Research

New dual CAR T cell immunotherapy shows enhanced therapeutic potency to fight HIV

Using SARS-CoV-2 epitope to construct a vaccine

Republican Convention, Day 4: Fireworks … and shining a light on Trump’s claims

Researchers develop advanced imaging technique to visualize effects of valencies on B cell responses

FDA continues to take action in the ongoing response to COVID-19 pandemic

FDA grants Abbott's COVID-19 rapid antigen test emergency-use authorization

Evidence of SARS-CoV-2 coronavirus particles in heart tissue

Pence praises Trump’s ‘seamless’ COVID response, leaves out his state feuds

New COVID-19 antigen test can be directly read from the testing card

UKRI funding could initiate clinical trial for Cambridge-developed DNA vaccine against SARS-CoV-2

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

Monoclonal antibodies may be a better choice than convalescent plasma for treating COVID-19

Preclinical studies of a COVID-19 vaccine candidate show positive results

Allowing low-level CMV infection may boost immunity in stem cell transplant recipients

Study reveals protective potential of all three major immunoglobulin isotypes against SARS-CoV-2

Lasting nature of IBD linked to a long-lived immune cell that provokes damaging inflammation

New cancer vaccine is predicted to be more effective in human trials

Trump is sending fast, cheap COVID tests to nursing homes — but there’s a hitch

Bio-Helix announces approved patent for ECL

Raccoon dogs potential intermediate host for SARS-CoV-2

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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