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Next-gen sequencing identifies thousands of cancer patients missing out on immunotherapy

Brigham researchers' findings from next-generation sequencing suggest that revising current cancer care guidelines could allow approximately 6,000 more patients in the U.S. to benefit from immunotherapy treatment each year

28 Dec 2023

Autopsy study provides new insights into yellow fever's impact on the heart

To fill gaps in knowledge of yellow fever (YF), a group of researchers in Brazil affiliated with the Department of Pathology at the University of São Paulo's Medical School (FM-USP), Hospital das Clínicas (HC, the hospital complex run by FM-USP), the Heart Institute (InCor, linked to HC) and Emílio Ribas Institute of Infectious Diseases (IIER) decided to study the pathogenesis of YF-associated heart injury.

19 Dec 2023

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Amidst a backdrop of industry-wide hurdles like inflation, talent scarcities, and stringent regulatory landscapes, Nona Biosciences is showing great promise as an emerging global leader in biotechnology.

From Nona BioSciences 19 Dec 2023

New vaccine strategy targets SARS-CoV-2's stable S2 subunit, offering broad protection against evolving variants

Study presents a new SARS-CoV-2 S2 subunit vaccine that elicits strong antibody responses against various sarbecovirus strains, including challenging variants like XBB.1.5, demonstrating its potential as a broadly effective and stable vaccine option.

18 Dec 2023

€7.4M EU grant boosts development of vaccines against Marburg viruses

International research consortium receives highly endowed Horizon Europe funding for the development of vaccines against Marburg viruses.

18 Dec 2023

Two proteins in the blood could predict dengue severity

Scientists and clinicians at Nanyang Technological University, Singapore (NTU Singapore) and the National Centre for Infectious Diseases (NCID) have identified two compounds - sST2 and suPAR - in the blood of dengue patients that could determine if a patient is at risk of severe dengue in the early phases of the disease.

18 Dec 2023

Antibody treatment shields transplant patients against COVID-19

New research from Cedars-Sinai's Comprehensive Transplant Center found that a monoclonal antibody treatment reduced the risk of COVID-19 in a large group of solid organ transplant patients who were administered the drug as a preventive measure against the disease.

18 Dec 2023

New dry powder aerosol COVID-19 vaccine shows promise against multiple virus strains

Study introduces a novel dry powder aerosol COVID-19 vaccine, showing its effectiveness in inducing strong immune responses and offering protection against various SARS-CoV-2 strains, including Omicron.

15 Dec 2023

Intranasal COVID-19 vaccine shows promise in reducing severe symptoms

Study evaluates the single-dose intranasal spray vaccine dNS1-RBD, finding it effective against symptomatic COVID-19, particularly in reducing severe symptoms and respiratory issues.

15 Dec 2023

NIAID study identifies critical T-cell function missing in prior HIV vaccine candidates

An effective HIV vaccine may need to prompt strong responses from immune cells called CD8+ T cells to protect people from acquiring HIV, according to a new study from researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and colleagues.

14 Dec 2023

New study highlights the need for advanced pneumococcal vaccines in the wake of pre-COVID data

The risk factors associated with CAP caused by serotypes in the different pneumococcal vaccines.

14 Dec 2023

U.S. veterans' study reveals key insights into Long COVID and protective role of vaccination

Study examines the clinical characteristics and trends of post-COVID-19 condition (PCC) in U.S. veterans, showing the protective effect of vaccination and the need for precise symptom documentation for effective research and clinical care.

12 Dec 2023

Nanoparticle vaccines can help fight zoonotic viral diseases

Announcing a new article publication for Zoonoses journal. Vaccines are the most promising tools for maintaining public health.

12 Dec 2023

Scientists develop new system to display epitopes in mammal cells for immunization studies

A new paper in Biology Methods & Protocols, published by Oxford University Press, indicates that researchers in Germany have developed a new system to display epitopes in mammal cells for immunization studies.

12 Dec 2023

Gene therapy shows promise for arrhythmogenic cardiomyopathy

Researchers evaluated the effectiveness of adeno-associated virus (AAV)-mediated Plakophilin 2 (PKP2) delivery in treating arrhythmogenic cardiomyopathy (ACM).

12 Dec 2023

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

The Malaghan Institute of Medical Research in collaboration with Wellington Zhaotai Therapies Limited today announced results of its phase 1 dose escalation trial of a new third-generation anti-CD19 chimeric antigen receptor (CAR) T-cell therapy to be presented at the American Society of Hematology (ASH) Annual Meeting in San Diego on 11 December, 3pm.

11 Dec 2023

CAR-T cell therapy remains viable for patients in lymphoma remission, study finds

A study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests that CAR-T immunotherapy remains a viable option for patients who have lymphoma that goes into remission before the cell therapy begins.

11 Dec 2023

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.

11 Dec 2023

New insights into the structures formed during antibody aggregation through 3D domain swapping

Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development.

8 Dec 2023

Fused pancreatic cancer organoid system captures tumor heterogeneity and drug resistance

Pancreatic ductal adenocarcinoma (PDAC), that arises from pancreatic epithelial cells, is the most common form of pancreatic cancer, with a very high mortality rate.

7 Dec 2023

Antigen News and Research

Next-gen sequencing identifies thousands of cancer patients missing out on immunotherapy

Autopsy study provides new insights into yellow fever's impact on the heart

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

New vaccine strategy targets SARS-CoV-2's stable S2 subunit, offering broad protection against evolving variants

€7.4M EU grant boosts development of vaccines against Marburg viruses

Two proteins in the blood could predict dengue severity

Antibody treatment shields transplant patients against COVID-19

New dry powder aerosol COVID-19 vaccine shows promise against multiple virus strains

Intranasal COVID-19 vaccine shows promise in reducing severe symptoms

NIAID study identifies critical T-cell function missing in prior HIV vaccine candidates

New study highlights the need for advanced pneumococcal vaccines in the wake of pre-COVID data

U.S. veterans' study reveals key insights into Long COVID and protective role of vaccination

Nanoparticle vaccines can help fight zoonotic viral diseases

Scientists develop new system to display epitopes in mammal cells for immunization studies

Gene therapy shows promise for arrhythmogenic cardiomyopathy

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

CAR-T cell therapy remains viable for patients in lymphoma remission, study finds

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

New insights into the structures formed during antibody aggregation through 3D domain swapping

Fused pancreatic cancer organoid system captures tumor heterogeneity and drug resistance

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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