Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Lack of physical activity and greater TV viewing time associated with wider retinal venules

It is well known that the lack of physical activity is a risk factor for cardiovascular diseases, but what part does it play in retinal vascular caliber? A team of researchers examined the association of physical activity and television viewing time with retinal vascular caliber and explored the differences in white, black, Hispanic and Chinese racial/ethnic groups.

6 May 2010

Research reveals reason for ineffectiveness of antioxidants against cardiovascular disease

A new study by researchers at the Swedish medical university Karolinska Institutet shows that the immune defence's T cells can attack the "bad" LDL cholesterol and thereby cause an inflammation that leads to atherosclerosis. By producing a vaccine against the T cell receptors, the researchers have managed to inhibit the development of atherosclerosis in animals.

6 May 2010

Micrus Endovascular reports 24% increase in fourth-quarter neurovascular revenues

Micrus Endovascular Corporation today reported financial results for the three and 12 months ended March 31, 2010 and introduced fiscal 2011 financial guidance.

6 May 2010

GENFIT announces milestone as compound developed in partnership enters the clinic

GENFIT (Alternext: ALGFT; ISIN: FR0004163111), a biopharmaceutical company at the forefront of drug discovery and development, focusing on the early diagnosis and preventive treatment of cardiometabolic and associated disorders, today announces the achievement of a milestone in the therapeutic research collaboration with one of its strategic pharmaceutical partners.

6 May 2010

ThromboGenics, BioInvent International report positive results from Phase II trial of TB-402 for VTE

ThromboGenics NV and co-development partner BioInvent International announce today positive results from their Phase II trial of TB-402. TB-402 is a novel, long acting anticoagulant that is being developed as a single injection for the prevention of venous thromboembolism (VTE) following orthopaedic surgery.

6 May 2010

New research suggests tPA can act as neuroprotectant against stroke

New research on the properties of the clot-busting stroke drug tPA (tissue-type plasminogen activator) suggests that tPA can act as a neuroprotectant and may form the keystone of an adaptive response to a reduction in blood flow.

6 May 2010

Animal study shows insulin prevents artery damage

Long suspected of worsening artery damage in patients with diabetes, insulin instead protects blood vessels, a new study by Joslin Diabetes Center scientists indicates.

5 May 2010

Idera Pharmaceuticals reports net loss of $1.9M for first-quarter 2010

Idera Pharmaceuticals, Inc., a biotechnology company engaged in the discovery and development of DNA- and RNA-based drug candidates targeted to Toll-like Receptors, today reported financial results for the first quarter ended March 31, 2010.

5 May 2010

Synageva BioPharma seeks FDA orphan drug designation for SBC-102 enzyme replacement therapy

Synageva BioPharma Corp., a privately held biopharmaceutical company, today announced its filing with the U.S. Food and Drug Administration (FDA) requesting orphan drug designation for its program, SBC-102. This program is an enzyme replacement therapy in preclinical development to treat lysosomal acid lipase (LAL) deficiency, also known as Wolman disease or cholesteryl ester storage disease (CESD), a condition for which there is currently no effective treatment.

4 May 2010

JNM supplement examines advances in cardiovascular molecular imaging

The Journal of Nuclear Medicine -the top-rated medical imaging journal worldwide-has published Multimodality Molecular Imaging of the Cardiovascular System, presenting the state of the art of cardiovascular molecular imaging and discussing opportunities and challenges in advancing cardiovascular molecular imaging to clinical practice.

4 May 2010

New data on salt-sensitive hypertension to be presented at ASH 2010 conference

With governmental authorities, academicians, healthcare providers and industry grappling with the level of salt in the diet in an effort to reduce its impact on high blood pressure, new data evaluating a potential genetic component to salt-sensitive hypertension will be presented at the American Society of Hypertension, Inc.'s 25th Annual Scientific Meeting and Exposition (ASH 2010).

4 May 2010

Natural plant extract could help treat COPD and inflammatory disorders

A widely and safely used plant extract acts as a novel anti-inflammatory agent that may one day be used for the treatment of chronic obstructive pulmonary disease, or COPD, as well as other inflammatory conditions.

4 May 2010

Data from Phase IV study of Bystolic tablets in Hispanic patients with hypertension presented at ASH 2010

Forest Laboratories, Inc. today presented data from a Phase IV study evaluating the effects of Bystolic (nebivolol) tablets in Hispanic patients with hypertension at the 2010 annual scientific meeting of the American Society of Hypertension.

4 May 2010

New diagnostic tool could help detect heart attacks

A diagnostic tool developed by Rice University scientists to detect heart attacks using a person's saliva is being tested at the Michael E. DeBakey VA Medical Center in collaboration with Baylor College of Medicine in Houston.

4 May 2010

CACS used to improve classification of risk for prediction of coronary heart disease events

Use of a score based on the amount of calcium in coronary arteries in addition to traditional risk factors improved the classification of risk for prediction of coronary heart disease events, and placed more individuals in the most extreme risk categories, according to a study in the April 28 issue of JAMA.

3 May 2010

CSI announces completion of enrollment in CALCIUM 360° clinical trial for PAD

Cardiovascular Systems, Inc. (CSI), has completed patient enrollment in its prospective, randomized CALCIUM 360° clinical trial, part of the company's 360° Clinical Series. The CALCIUM 360° feasibility study is evaluating the treatment of peripheral arterial disease (PAD) behind and below the knee using CSI's Diamondback 360® System, a minimally invasive catheter for treating PAD anywhere in the leg. Dr. Nicolas Shammas, an interventional cardiologist at Trinity Medical Center, Bettendorf, Iowa, is the study's principal investigator.

30 Apr 2010

Higher the blood cholesterol level, greater the risk of atherosclerosis: Study

In addition to crystallized cholesterol, atherosclerotic plaques always contain large quantities of immune cells but, surprisingly, no bacteria or viruses. It was previously unclear just how the body's own defence forces are called into action. Even animals that are kept in an absolutely sterile environment can suffer from "clogging" or "furring" of the arteries when their food contains high levels of cholesterol.

29 Apr 2010

Coronary artery calcium score helpful for determining intermediate risk of heart disease

Including a coronary artery calcium score in a risk assessment for future heart disease events, such as heart attacks, provides a better estimate in some populations than a standard coronary risk factors assessment, according to research supported by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health.

28 Apr 2010

Study suggests potential ingredient in rice for prevention of cardiovascular diseases

Rice is generally thought to be a healthy addition to the diet because it is a source of fiber. However, not all rice is equally nutritious, and brown rice might have an advantage over white rice by offering protection from high blood pressure and atherosclerosis ("hardening of the arteries"), say researchers at the Cardiovascular Research Center and Department of Physiology at Temple University School of Medicine in Philadelphia.

27 Apr 2010

Popular antidepressants may have beneficial side effects for cardiovascular health: Study

A class of antidepressants known as selective serotonin reuptake inhibitors may provide a boost to cardiovascular health by affecting the way platelets, small cells in the blood involved in clotting, clump together, say researchers at the Loyola University Medical Center in Maywood, Ill.

26 Apr 2010

Atherosclerosis News and Research

Further Reading

Lack of physical activity and greater TV viewing time associated with wider retinal venules

Research reveals reason for ineffectiveness of antioxidants against cardiovascular disease

Micrus Endovascular reports 24% increase in fourth-quarter neurovascular revenues

GENFIT announces milestone as compound developed in partnership enters the clinic

ThromboGenics, BioInvent International report positive results from Phase II trial of TB-402 for VTE

New research suggests tPA can act as neuroprotectant against stroke

Animal study shows insulin prevents artery damage

Idera Pharmaceuticals reports net loss of $1.9M for first-quarter 2010

Synageva BioPharma seeks FDA orphan drug designation for SBC-102 enzyme replacement therapy

JNM supplement examines advances in cardiovascular molecular imaging

New data on salt-sensitive hypertension to be presented at ASH 2010 conference

Natural plant extract could help treat COPD and inflammatory disorders

Data from Phase IV study of Bystolic tablets in Hispanic patients with hypertension presented at ASH 2010

New diagnostic tool could help detect heart attacks

CACS used to improve classification of risk for prediction of coronary heart disease events

CSI announces completion of enrollment in CALCIUM 360° clinical trial for PAD

Higher the blood cholesterol level, greater the risk of atherosclerosis: Study

Coronary artery calcium score helpful for determining intermediate risk of heart disease

Study suggests potential ingredient in rice for prevention of cardiovascular diseases

Popular antidepressants may have beneficial side effects for cardiovascular health: Study

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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