Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Statins lower C-reactive protein (CRP), a major new risk factor for heart disease marked by inflammation

For years, doctors have believed that statin therapy lowers the risk of heart disease solely by lowering levels of cholesterol.

9 Jan 2005

Reduced progression of atherosclerosis tied to statin drugs lowering fats, protein

Aggressive therapy with statins -- drugs that inhibit cholesterol synthesis -- works better than moderate statin therapy in reducing fats and proteins in the blood that have been linked to atherosclerosis, a new multi-center study concludes. Statins’ effects on both complex compounds appear beneficial in cutting patients’ cardiovascular risks.

6 Jan 2005

People with migraine headaches report more angina, but not more heart disease

People with a history of migraines and other headaches lasting at least four hours are more likely to report suffering from the chest pain doctors call angina than people who do not experience such headaches, a new University of North Carolina at Chapel Hill study concludes.

28 Dec 2004

Course of injections in childhood might help protect people from heart disease later in life

A course of injections in childhood might help protect people from heart disease later in life. And for those whose arteries are already clogged up, a dose of antibodies could provide immediate benefits. That's the enticing vision raised by animal studies.

26 Dec 2004

Prevalence of overweight increased in children aged two to four years from low-income families

The prevalence of overweight increased from 1989 to 2000 in children aged two to four years from low-income families, according to an article in the December issue of The Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

6 Dec 2004

New research may lead to treatments for atherosclerosis

Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

29 Nov 2004

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Scientists have found that overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) blocks the formation of new blood vessels and thus reduces tumor growth. Therapeutics based on this finding may potentially lead to new cancer treatments.

19 Nov 2004

New findings have implications for chronic use of COX-2 Inhibitors in pre-menopausal women

Heart disease is less pronounced in women than in men as humans age, but this difference narrows after menopause. Some studies have shown that estrogen slows heart disease in mouse models, but the mechanism is largely unknown.

18 Nov 2004

Concord grapes increase good cholesterol

Drinking Concord grape juice significantly increased HDL--the good cholesterol--and significantly lowered two markers of inflammation in people with stable coronary artery disease, according to results of a study presented in the November issue of the journal Arteriosclerosis, Thrombosis and Vascular Biology.

16 Nov 2004

Startling new blood pressure findings - atherosclerosis slowed

A new study led by The Cleveland Clinic shows that giving blood pressure lowering medication to heart disease patients with a “normal” blood pressure dramatically reduces risk of adverse cardiac events and slows disease progression.

16 Nov 2004

Vasogen announces full patient enrollment in its trial of Celacade in peripheral arterial disease

Vasogen today announced that it has reached full enrollment in its 500-patient pivotal phase III SIMPADICO trial of Celacade (immune modulation therapy) for the treatment of peripheral arterial disease (PAD).

16 Nov 2004

Four major U.S. ethnic groups less likely to have cholesterol controlled

Compared with non-Hispanic whites, non-Hispanic blacks and Hispanics who qualify for cholesterol-lowering drug treatment are less likely to have their “bad” LDL cholesterol controlled to recommended levels, researchers reported at the American Heart Association’s Scientific Sessions 2004.

11 Nov 2004

Dietary supplement DHEA could play a role in reducing abdominal fat in elderly men and women

Preliminary research indicates that the dietary supplement DHEA could play a role in reducing abdominal fat in elderly men and women with age-related decreases in DHEA levels, according to a study in the November 10 issue of JAMA.

10 Nov 2004

Calcium channel blocker reduces adverse cardiovascular events

The calcium channel blocker amlodipine decreases the risk of cardiovascular events (such as heart attack or heart-disease related deaths) in patients with coronary artery disease and normal blood pressure, as does the ACE inhibitor enalapril, but to a lesser extent, according to a study in the November 10 issue of JAMA.

10 Nov 2004

Lipid Sciences' selective delipidation process demonstrates enhanced ability in removing cholesterol from cells

Lipid Sciences announced today that researchers have successfully used the Company's proprietary "selective delipidation" process to create a modified form of HDL ("good cholesterol") that is known to be more effective in reverse cholesterol transport, the body's natural process for removing lipids from arterial plaque.

8 Nov 2004

Association between long-term air pollution exposure and the early stages of atherosclerosis

Air pollution may trigger and accelerate narrowing of carotid arteries, according to a study presented at the American Heart Association's Scientific Sessions 2004.

8 Nov 2004

High-dose statin therapy for aggressive cholesterol-lowering outperforms typical care

Patients treated with high doses of atorvastatin had about a one percent lower annual rate of heart attacks than similar patients receiving usual care, according to a new study in the Nov. 2, 2004 issue of the Journal of the American College of Cardiology.

2 Nov 2004

Do cholesterol-reducing drugs decrease the risk of heart attacks and strokes in diabetics?

International researchers will, for the first time, present findings from the landmark 4D trial about whether a cholesterol-reducing drug decreases the risk of heart attacks and strokes with type 2 diabetics on dialysis at the American Society of Nephrology’s 37th Annual Meeting and Scientific Exposition in St. Louis, Missouri.

1 Nov 2004

Study supports earlier findings, and even showed a significantly higher prevalence of periodontal diseases in cardiac patients

Research is racing to help healthcare professionals further understand how periodontal diseases are linked to cardiovascular disease.

28 Oct 2004

Impaired endothelial function is an early indicator of atherosclerosis

Impaired endothelial function is an early indicator of atherosclerosis according to a study of healthy people followed from childhood to young adulthood reported in Circulation: Journal of the American Heart Association.

25 Oct 2004

Atherosclerosis News and Research

Further Reading

Statins lower C-reactive protein (CRP), a major new risk factor for heart disease marked by inflammation

Reduced progression of atherosclerosis tied to statin drugs lowering fats, protein

People with migraine headaches report more angina, but not more heart disease

Course of injections in childhood might help protect people from heart disease later in life

Prevalence of overweight increased in children aged two to four years from low-income families

New research may lead to treatments for atherosclerosis

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

New findings have implications for chronic use of COX-2 Inhibitors in pre-menopausal women

Concord grapes increase good cholesterol

Startling new blood pressure findings - atherosclerosis slowed

Vasogen announces full patient enrollment in its trial of Celacade in peripheral arterial disease

Four major U.S. ethnic groups less likely to have cholesterol controlled

Dietary supplement DHEA could play a role in reducing abdominal fat in elderly men and women

Calcium channel blocker reduces adverse cardiovascular events

Lipid Sciences' selective delipidation process demonstrates enhanced ability in removing cholesterol from cells

Association between long-term air pollution exposure and the early stages of atherosclerosis

High-dose statin therapy for aggressive cholesterol-lowering outperforms typical care

Do cholesterol-reducing drugs decrease the risk of heart attacks and strokes in diabetics?

Study supports earlier findings, and even showed a significantly higher prevalence of periodontal diseases in cardiac patients

Impaired endothelial function is an early indicator of atherosclerosis

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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