Biochemistry News and Research

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Research to determine how genes contribute to Type 1 diabetes

Diabetes is a chronic, debilitating disease which affects nearly 26 million Americans. As many as three million people have Type 1 diabetes or juvenile diabetes that usually occurs in children or young adults.

19 Oct 2012

Chloride-restrictive intravenous strategy may decrease incidence of AKI among critically ill patients

In a pilot study assessing the effect of different levels of chloride in intravenous fluids administered to critically ill patients in an intensive care unit, restricting the amount of chloride administration was associated with a significant decrease in the incidence of acute kidney injury and the use of renal replacement therapy, according to a study in the October 17 issue of JAMA.

17 Oct 2012

Researchers identify critical mechanisms of epigenetic cell programming

A team of researchers at the IRCM, supervised by Dr. Jacques Drouin, reprogrammed the identity of cells in the pituitary gland and identified critical mechanisms of epigenetic cell programming.

17 Oct 2012

USC project seeks to answer important questions about cancer

Three groups of University of Southern California (USC) researchers-representing medicine, chemistry and chemical engineering-are recipients of highly competitive grants from the National Institutes of Health's National Cancer Institute (NCI).

11 Oct 2012

NACA could prevent or cure cataracts, macular degeneration and other eye conditions

Researchers at Missouri University of Science and Technology are working with an antioxidant that could prevent or cure cataracts, macular degeneration and other degenerative eye disorders.

10 Oct 2012

ProteoWizard Toolkit interprets multi-platform mass spectrometry data

The world's leading mass spectrometer manufacturers have agreed to license technology that enabled University of Southern California (USC) researchers to develop software that, for the first time, allows scientists to easily use and share research data collected across proprietary platforms.

From Thermo Fisher Scientific Inc. 10 Oct 2012

IspH protein accepts two completely different classes of molecules as partners

The iron-sulfur protein IspH plays a central role in the terpene metabolism of several pathogens. The mechanism of the reaction provides an approach for developing new antibiotics, particularly against malaria and tuberculosis. While researching this enzyme, biochemists at the Technische Universitat Munchen discovered a previously unknown reaction: IspH accepts two completely different classes of molecules as partners.

10 Oct 2012

Perplexing evolutionary history of malaria transmitting mosquito species

An African mosquito species with a deadly capacity to transmit malaria has a perplexing evolutionary history, according to discovery by researchers at the Fralin Life Science Institute at Virginia Tech.

6 Oct 2012

Study reveals atomic-level structure of the human peptidase enzyme meprin β

An international research team led by the Spanish National Research Council (CSIC) and researchers from Kiel University revealed the atomic-level structure of the human peptidase enzyme meprin β (beta).

5 Oct 2012

SLU professor to investigate natural history and progression of Alpha-1 Antitrypsin Deficiency

Jeffrey Teckman, M.D., professor of pediatrics and biochemistry and molecular biology at Saint Louis University, has received a $1.4 million grant from the Alpha-1 Foundation to investigate the natural history and progression of Alpha-1 Antitrypsin Deficiency, an inherited disease that can cause liver damage in children as well as adults.

4 Oct 2012

Simple new test can monitor treatment of eosinophilic esophagitis

A simple new test, in which the patient swallows a string, can monitor treatment of eosinophilic esophagitis as effectively as an invasive, expensive and uncomfortable procedure that risks complications, particularly in children.

4 Oct 2012

GW researcher to help HIV patients better understand treatments for cardiovascular issues

In 1980, men and women who were diagnosed with the human immunodeficiency virus (HIV) had little to no hope of living long, full lives. Thanks to advances in science and medicine, this is no longer the case. HIV patients now live a near-normal lifespan. However, as patients live longer, new medical issues arise.

3 Oct 2012

Zinc deficiency mechanism associated with many health problems, aging

A new study has outlined for the first time a biological mechanism by which zinc deficiency can develop with age, leading to a decline of the immune system and increased inflammation associated with many health problems, including cancer, heart disease, autoimmune disease and diabetes.

2 Oct 2012

Research report helps explain how macrophages accumulate triglycerides

A research report appearing in the Journal of Leukocyte Biology helps explain how specific immune cells, called macrophages, accumulate triglycerides to support their function.

2 Oct 2012

Bioengineers design inexpensive, rapid medical diagnostic tests

By mimicking nature's own sensing mechanisms, bioengineers at UC Santa Barbara and University of Rome Tor Vergata have designed inexpensive medical diagnostic tests that take only a few minutes to perform.

29 Sep 2012

Cholesterol precursor suppresses inflammatory response genes, causes atherosclerosis

Atherosclerosis - the hardening of arteries that is a primary cause of cardiovascular disease and death - has long been presumed to be the fateful consequence of complicated interactions between overabundant cholesterol and resulting inflammation in the heart and blood vessels.

28 Sep 2012

Lessons on the journey to commercialisation

One of the Asia Pacific region’s best known biotech leaders, Dr Greg Collier, says successful commercialisation of a new drug or therapy takes, “discipline, a strong set of nerves and a stroke of luck.”

28 Sep 2012

UNMCC to investigate R-ketorolac use against ovarian cancer cells

Most drugs take ten years-and frequently, more-to go from concept to FDA approval. One way to reduce this time investment is to look for already-approved drugs that could be put to new uses. And that's just what Angela Wandinger-Ness, PhD, UNM Professor of Pathology, and Laurie Hudson, PhD, UNM Professor of Pharmaceutical Sciences, have done.

28 Sep 2012

Key bacterial protein structures reveal one of the biochemical secrets behind multi-drug tolerance

The structures of key bacterial proteins have revealed one of the biochemical secrets that enables bacteria to outwit antibiotics.

27 Sep 2012

Karolinska Institutet scientists discover new approach to treat type II diabetes

An international team of scientists, led from Karolinska Institutet in Sweden, have discovered an entirely new approach to the treatment of type II diabetes. The therapy involves the blockade of signalling by a protein known as VEGF-B and this prevents fat from accumulating in the 'wrong' places, such as in muscles and in the heart. As a result the cells within these tissues are once again able to respond to insulin.

27 Sep 2012

Biochemistry News and Research

Research to determine how genes contribute to Type 1 diabetes

Chloride-restrictive intravenous strategy may decrease incidence of AKI among critically ill patients

Researchers identify critical mechanisms of epigenetic cell programming

USC project seeks to answer important questions about cancer

NACA could prevent or cure cataracts, macular degeneration and other eye conditions

ProteoWizard Toolkit interprets multi-platform mass spectrometry data

IspH protein accepts two completely different classes of molecules as partners

Perplexing evolutionary history of malaria transmitting mosquito species

Study reveals atomic-level structure of the human peptidase enzyme meprin β

SLU professor to investigate natural history and progression of Alpha-1 Antitrypsin Deficiency

Simple new test can monitor treatment of eosinophilic esophagitis

GW researcher to help HIV patients better understand treatments for cardiovascular issues

Zinc deficiency mechanism associated with many health problems, aging

Research report helps explain how macrophages accumulate triglycerides

Bioengineers design inexpensive, rapid medical diagnostic tests

Cholesterol precursor suppresses inflammatory response genes, causes atherosclerosis

Lessons on the journey to commercialisation

UNMCC to investigate R-ketorolac use against ovarian cancer cells

Key bacterial protein structures reveal one of the biochemical secrets behind multi-drug tolerance

Karolinska Institutet scientists discover new approach to treat type II diabetes

Biochemistry eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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