Biochemistry News and Research

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TAM protein complex - a potential antibacterial target

Scientists could produce new antibacterial treatments by disarming the molecular pumps bacteria use to bring disease causing molecules in contact with animals and humans.

6 Apr 2012

Advaxis, Karolinska Institutet enter collaboration to develop cat allergy vaccine

Advaxis, Inc.,, a leader in developing the next generation of immunotherapies for cancer and infectious diseases, announced that it has entered into a research collaboration with Professor Marianne van Hage, research group leader and Head of the Clinical Immunology and Allergy Unit and Vice Head of the Department of Medicine at Karolinska Institutet in Stockholm, Sweden.

6 Apr 2012

ARI-4175 drug may treat colorectal cancer patients with KRAS mutation

When combined with other treatments, the drug cetuximab-which works by slowing or stopping the growth of cancer cells-has been shown to extend survival in certain types of cancer, including metastatic colorectal cancers. Unfortunately, about 40 percent of colorectal cancer patients-specifically those who carry a mutated form of a gene called KRAS-do not respond to the drug. Researchers at Fox Chase Cancer Center in Philadelphia, however, have been working on a way to overcome this resistance to cetuximab by unleashing a second cetuximab driven mechanism using a novel drug called ARI-4175.

5 Apr 2012

UH to host 'Science Impacting Health and Society' lecture series

A new lecture series at the University of Houston (UH) will give Houstonians an opportunity to learn how science is making a difference in health and medicine. The first of five lectures will be held from 7 to 8 p.m. Wednesday, April 25 at the Hilton University of Houston.

5 Apr 2012

Scientists uncover structure and operating mechanism of TPPII

Uncontrolled or inaccurate degradation of cellular proteins can lead to diseases like cancer or Alzheimer's disease. Scientists of the Max Planck Institute of Biochemistry (MPIB) in Martinsried near Munich, Germany, have now uncovered the structure and the operating mechanism of an important component of the human cellular degradation machinery, tripeptidyl peptidase II.

5 Apr 2012

Walter and Eliza Hall Institute researchers receive five ASBMB awards

Walter and Eliza Hall Institute researchers have received five of the 11 awards for excellence in biochemistry and microbiology announced by the Australian Society of Biochemistry and Molecular Biology (ASBMB) this month.

5 Apr 2012

Gbb38 protein helps explain how cells send many long-haul messages

As they work together to form body parts, cells in developing organisms communicate like workers at a construction site. The discovery of a new signaling molecule in flies by Brown University biologists not only helps explain how cells send many long-haul messages, but also provides new clues for researchers who study how human development goes awry, for instance in cases of cleft lip and palate.

3 Apr 2012

TLR4/MD-2 protein complex triggers morphine-induced inflammation

A University of Colorado Boulder-led research team has discovered that two protein receptors in the central nervous system team up to respond to morphine and cause unwanted neuroinflammation, a finding with implications for improving the efficacy of the widely used painkiller while decreasing its abuse potential.

3 Apr 2012

Combination treatment effective against melanoma

Research from The Cancer Institute of New Jersey (CINJ) shows that a coordinated effort to block signaling pathways that promote cancer cell growth and survival enhances programmed cell death in melanoma.

3 Apr 2012

Researchers discover regulation and functional significance of acute phase response during pneumonia

Researchers at Boston University School of Medicine (BUSM) have discovered the regulation and functional significance of the acute phase response during a lung infection. The findings, which will be published in the May edition of the Journal of Clinical Investigation, demonstrate that the liver responds in order to increase defenses in the blood that prevent localized infections from spreading throughout the body.

3 Apr 2012

Stimulating specific neurons may reverse age-related memory defects

Scientists from the Florida campus of The Scripps Research Institute have shown in animal models that the loss of memory that comes with aging is not necessarily a permanent thing.

3 Apr 2012

Clemson researcher to continue African sleeping sickness study

Clemson University researcher James Morris received a $360,079 competitive renewal grant from the National Institutes of Health to continue his study of Trypanosoma brucei, the single-celled parasite that causes African sleeping sickness.

3 Apr 2012

Metformin prevents primary liver cancer in animal models

Metformin, a drug widely used to treat Type II diabetes, may help to prevent primary liver cancer, researchers at the University of Maryland Marlene and Stewart Greenebaum Cancer Center report in the April 2012 issue of Cancer Prevention Research.

2 Apr 2012

Platelet activating factor plays a crucial role in development of graft-versus-host disease

A new discovery in mice may lead to new treatments that could make bone marrow transplants more likely to succeed and to be significantly less dangerous.

2 Apr 2012

TRIM28 protein essential after fertilisation to preserve epigenetic marks on imprinted genes

An international team led by scientists at A*STAR's Institute of Medical Biology (IMB) discovered that a protein, called TRIM28, normally present in the mother's egg, is essential right after fertilisation, to preserve certain chemical modifications or 'epigenetic marks' on a specific set of genes.

30 Mar 2012