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Researchers identify microbial enzyme responsible for making urine yellow

Researchers at the University of Maryland and National Institutes of Health have identified the microbial enzyme responsible for giving urine its yellow hue, according to a new study published in the journal Nature Microbiology on January 3, 2024.

3 Jan 2024

Understanding acylspermidines' secrets could lead to treatments for various diseases

In a significant advancement in the field of biochemistry, scientists at the Boyce Thompson Institute (BTI) and Cornell University have uncovered new insights into a family of metabolites, acylspermidines, that could change how we understand aging and fight diseases.

2 Jan 2024

New family of polymers can kill bacteria without inducing antibiotic resistance

Antibiotic-resistant bacteria have become a rapidly growing threat to public health. Each year, they account for more than 2.8 million infections, according to the U.S. Centers for Disease Control and Prevention.

22 Dec 2023

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

22 Dec 2023

Protein "on/off switch" controls breast cancer spread and immunotherapy response

Despite their promise, immunotherapies fail to treat many cancers, including over 80% of some of the most advanced breast cancers.

20 Dec 2023

TMDU researchers develop novel method to identify protein-protein binding interfaces

Proteins are building blocks of our bodies, but they do not work solo. They form partners to facilitate in different biological processes that keep us going.

20 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

UMass Amherst researchers develop novel strategy to outsmart antibiotic-resistant ‘superbugs’

Antibiotic-resistant "superbugs" that can defeat efforts to kill them are an urgent public health crisis, and according to the Centers for Disease Control, more than 2.8 million antibiotic-resistant infections occur each year.

18 Dec 2023

Deep learning designs high-affinity protein binders for bioactive helical peptides

A new study Dec. 18 in Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring.

18 Dec 2023

Spatial and subtype-specific regulation of ribosomal RNA genes in Arabidopsis revealed

Arabidopsis thaliana is a species grown worldwide for genetic research and was the first plant to have its complete set of chromosomes (its genome) sequenced.

15 Dec 2023

Researchers reveal a connection between cellular metabolism and depression, suicidal ideation

Major depressive disorder affects 16.1 million adults in the United States and costs $210 billion annually. While the primary symptoms of depression are psychological, scientists and doctors have come to understand that depression is a complex disease with physical effects throughout the body.

15 Dec 2023

Hemoglobin-like protein plays an important role in the development of the heart, study finds

In a landmark study led by the University of Maryland School of Medicine, researchers discovered for the first time that a certain kind of protein similar to hemoglobin, called cytoglobin, plays an important role in the development of the heart.

15 Dec 2023

Protective bacterial communities consume the nutrients to starve out pathogens

The human gut is home to hundreds of different bacterial species collectively known as the gut microbiome.

15 Dec 2023

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

A multidisciplinary study published in Nature has elucidated the structure of the machinery responsible for writing much of our "dark genome" -; the 98 percent of our DNA that has largely unknown biological function.

14 Dec 2023

Researchers unveil new way to sensitize resistant tumors to treatment

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death.

14 Dec 2023

UVA atlas unveils cellular blueprint of atherosclerosis

University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes and coronary artery disease.

12 Dec 2023

UB research identifies key mechanism in infantile cystinosis

University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the lifespan of patients.

11 Dec 2023

New drug combo shows promise in targeting RAS-mutant multiple myeloma

The combination of a drug and a protein fragment prevents the growth of blood cancer cells, a new study in mice shows.

11 Dec 2023

Study unlock secrets of Zika virus's multipurpose enzyme and reveals therapeutic vulnerability

Viruses have limited genetic material-;and few proteins-;so all the pieces must work extra hard. Zika is a great example; the virus only produces 10 proteins.

8 Dec 2023

Vanderbilt's potential schizophrenia treatment enters phase 1 clinical trials

A potential schizophrenia treatment discovered through the Warren Center for Neuroscience Drug Discovery has been cleared by the U.S. Food and Drug Administration for use in phase 1 clinical trials-;the third WCNDD therapeutic to reach that benchmark.

7 Dec 2023

Biochemistry News and Research

Researchers identify microbial enzyme responsible for making urine yellow

Understanding acylspermidines' secrets could lead to treatments for various diseases

New family of polymers can kill bacteria without inducing antibiotic resistance

St. Jude researchers crack the code of the β2-adrenergic receptor

Protein "on/off switch" controls breast cancer spread and immunotherapy response

TMDU researchers develop novel method to identify protein-protein binding interfaces

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

UMass Amherst researchers develop novel strategy to outsmart antibiotic-resistant ‘superbugs’

Deep learning designs high-affinity protein binders for bioactive helical peptides

Spatial and subtype-specific regulation of ribosomal RNA genes in Arabidopsis revealed

Researchers reveal a connection between cellular metabolism and depression, suicidal ideation

Hemoglobin-like protein plays an important role in the development of the heart, study finds

Protective bacterial communities consume the nutrients to starve out pathogens

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

Researchers unveil new way to sensitize resistant tumors to treatment

UVA atlas unveils cellular blueprint of atherosclerosis

UB research identifies key mechanism in infantile cystinosis

New drug combo shows promise in targeting RAS-mutant multiple myeloma

Study unlock secrets of Zika virus's multipurpose enzyme and reveals therapeutic vulnerability

Vanderbilt's potential schizophrenia treatment enters phase 1 clinical trials

Biochemistry eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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