Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

New biomarker for pancreatic cancer effectively targets potential therapy for small survival rate

University of Cincinnati (UC) researchers have discovered a biomarker, known as phosphatidylserine (PS), for pancreatic cancer that could be effectively targeted, creating a potential therapy for a condition that has a small survival rate.

5 Oct 2013

Cynvenio launches ClearID Breast Cancer monitoring program

Cynvenio, a cancer diagnostics company focused on transforming cancer treatment and management through the molecular analysis of tumor biomarkers in blood, today launched a new weapon in the fight against breast cancer, the ClearID Breast Cancer monitoring program.

4 Oct 2013

Findings may result in better management of chronic depression

Virginia Commonwealth University has received a $3 million grant from the National Institute of Mental Health to study key molecular markers found in DNA that predict chronic depression.

2 Oct 2013

Genetic discovery could take guesswork out of prescribing correct dose of drugs

The discovery of genetic differences affecting up to a third of the population could take the guesswork out of prescribing the correct dose of 25 percent of drugs currently on the market, researchers say.

2 Oct 2013

Final patient completion of phase II study of TR040303 in patients treated for acute myocardial infarction announced by Trophos

Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for indications with under-served needs in neurology and cardiology, announces today the final patient completion of a phase II study of TR040303 in patients treated for acute myocardial infarction (MI). Outcome data of this study is expected to be available towards the end of 2013.

2 Oct 2013

Researchers discover how aspirin improves survival in patients diagnosed with colon cancer

Researchers believe they have discovered how aspirin improves survival in patients diagnosed with colon cancer, the 2013 European Cancer Congress (ECC2013) heard today.

1 Oct 2013

Researchers discover how aspirin improves survival in patients with colon cancer

Researchers believe they have discovered how aspirin improves survival in patients diagnosed with colon cancer, the 2013 European Cancer Congress heard today (Monday).

30 Sep 2013

Studies show evidence-guided molecular profiling improves treatment for hard-to-treat cancers

Caris Life Sciences announced today data from two studies presented at the 2013 European Cancer Congress, which demonstrate the potential of evidence-guided molecular profiling to immediately improve the treatment of patients with hard-to-treat cancers, including cancers of unknown primary (CUP) origins as well as rare tumors and cancers that have been refractory to treatment.

29 Sep 2013

New ultra-specific test now available for prostate cancer

A new urine test for prostate cancer that measures minute fragments of RNA is now commercially available to men nationwide through the University of Michigan MLabs.

27 Sep 2013

Copenhagen researchers gain insight in molecular mechanisms behind breast cancer metastasis

Researchers at University of Copenhagen have gained more insight into the molecular mechanisms of importance for, for example, cancer cell growth and metastasis. The research objective is improved and more targeted drugs. The findings have just been published in the scientific journal Molecular Cell.

26 Sep 2013

NCI Re-Ups Biomarker Strategies’ SBIR Award For Melanoma Cdx

BioMarker Strategies received a $1.5 million SBIR award to develop a pathway-based companion diagnostic test to facilitate the selection of optimal therapy for patients with melanoma. This award was preceded by an NCI award of $200,000 almost two years ago in September 2011.

25 Sep 2013

Immune marker prognostic after non-clear cell RCC surgery

The preoperative neutrophil-to-lymphocyte ratio is associated with disease-free survival in patients undergoing resection of localized non-clear cell renal cell carcinoma, research shows.

24 Sep 2013

Scientists validate new system for identifying individuals with preclinical Alzheimer's disease

For years, scientists have attempted to understand how Alzheimer's disease harms the brain before memory loss and dementia are clinically detectable. Most researchers think this preclinical stage, which can last a decade or more before symptoms appear, is the critical phase when the disease might be controlled or stopped, possibly preventing the failure of memory and thinking abilities in the first place.

24 Sep 2013

Protein pair may be prognostic biomarker for identifying smoking-related lung cancers

Mayo Clinic researchers have shown that a specific protein pair may be a successful prognostic biomarker for identifying smoking-related lung cancers. The protein — ASCL1 — is associated with increased expression of the RET oncogene, a particular cancer-causing gene called RET. The findings appear in the online issue of the journal Oncogene.

20 Sep 2013

Iron levels hint at resistance to harmful effects of smoking

Researchers from Japan say that serum iron levels could be a biomarker that indicates which smokers are resistant to the effects of cigarette smoke on lung function.

19 Sep 2013

Florida Hospital To Evaluate VTT’S Alzheimer’S Biomarker Assay

VTT Technical Research Centre of Finland is taking an important step toward advancing its Alzheimer's disease biomarker by collaborating with the Florida Hospital Neuroscience Institute to evaluate screening, diagnostic, and prognostic potential of the biomarker assay and utilize it to specifically target which types of precautions to take when approaching early stages of the disease.

19 Sep 2013

Blood lipid marker may help predict risk for Parkinson's disease

A genetic mutation, known as GBA, that leads to early onset of Parkinson's disease and severe cognitive impairment (in about 4 to 7 percent of all patients with the disease) also alters how specific lipids, ceramides and glucosylceramides are metabolized. Mayo Clinic researchers have found that Parkinson's patients who do not carry the genetic mutation also have higher levels of these lipids in the blood. Further, those who had Parkinson's and high blood levels were also more likely to have cognitive impairment and dementia.

19 Sep 2013

OGT to share expertise in NGS assay design through live webinar presentation

Oxford Gene Technology, provider of innovative genetics research and biomarker solutions to advance molecular medicine, will share its expertise in NGS assay design by hosting a live webinar entitled ‘Enhanced bait design strategies that deliver more reliable NGS panel assays’ on 3rd October 2013, at 3:00pm (BST).

From Oxford Gene Technology 19 Sep 2013

SHBG protein indicates risk of type 2 diabetes and metabolic syndrome years in advance

Over the last decade researchers have amassed increasing evidence that relatively low levels of a protein called sex hormone binding globulin (SHBG) can indicate an elevated risk of type 2 diabetes and metabolic syndrome years in advance.

19 Sep 2013

Promising early findings from Parkinson’s biomarker study

Early results from the Parkinson’s Progression Markers Initiative suggest that some cerebrospinal fluid biomarkers hold diagnostic and prognostic promise.

18 Sep 2013

Biomarker News and Research

Further Reading

New biomarker for pancreatic cancer effectively targets potential therapy for small survival rate

Cynvenio launches ClearID Breast Cancer monitoring program

Findings may result in better management of chronic depression

Genetic discovery could take guesswork out of prescribing correct dose of drugs

Final patient completion of phase II study of TR040303 in patients treated for acute myocardial infarction announced by Trophos

Researchers discover how aspirin improves survival in patients diagnosed with colon cancer

Researchers discover how aspirin improves survival in patients with colon cancer

Studies show evidence-guided molecular profiling improves treatment for hard-to-treat cancers

New ultra-specific test now available for prostate cancer

Copenhagen researchers gain insight in molecular mechanisms behind breast cancer metastasis

NCI Re-Ups Biomarker Strategies’ SBIR Award For Melanoma Cdx

Immune marker prognostic after non-clear cell RCC surgery

Scientists validate new system for identifying individuals with preclinical Alzheimer's disease

Protein pair may be prognostic biomarker for identifying smoking-related lung cancers

Iron levels hint at resistance to harmful effects of smoking

Florida Hospital To Evaluate VTT’S Alzheimer’S Biomarker Assay

Blood lipid marker may help predict risk for Parkinson's disease

OGT to share expertise in NGS assay design through live webinar presentation

SHBG protein indicates risk of type 2 diabetes and metabolic syndrome years in advance

Promising early findings from Parkinson’s biomarker study

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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