Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Blood test provides tool essential to trials of therapies for Huntington's disease

An assay designed to measure normal and abnormal forms of the huntingtin protein - the mutated form of which causes Huntington's disease - was successful in detecting levels of the mutant protein in a large multicenter study of individuals at risk for the devastating neurological disorder.

30 Aug 2013

Blood biomarkers predict suicidality

Researchers have found possible blood biomarkers for suicidal behavior that could help identify psychiatric patients at risk.

29 Aug 2013

JCVI Receives $1.25M For Healthy Aging Study

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29 Aug 2013

JCVI Receives $1.25M For Healthy Aging Study

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28 Aug 2013

Researchers develop ddPCR technology to quantify rejection biomarker in organ transplant injury

A recently reported blood test for the early detection of organ transplant injury could enable more timely therapeutic intervention in transplant patients and thus help to avoid longer term damage. As described by scientists at the University Medical Center G-ttingen and Chronix Biomedical, a molecular diagnostics company, the new method uses Bio-Rad Laboratories' Droplet Digital PCR (ddPCR-) technology to overcome the obstacles of earlier tests, which were both time-consuming and costly.

28 Aug 2013

ASO may correct striatal transcriptional abnormalities and improve behavioral problems in HD mice

Findings from postmortem studies of the brains of Huntington's Disease (HD) patients suggest that transcriptional dysregulation may be an early step in the pathogenesis of HD before symptoms appear. Other studies report transcriptional alterations in the brains of some mouse models of HD.

27 Aug 2013

Comprehensive test of biomarkers have prognostic and diagnostic value in Parkinson's disease

Perelman School of Medicine researchers at the University of Pennsylvania report the first biomarker results reported from the Parkinson's Progression Markers Initiative (PPMI), showing that a comprehensive test of protein biomarkers in spinal fluid have prognostic and diagnostic value in early stages of Parkinson's disease.

27 Aug 2013

CA-125: Screening tool to detect ovarian cancer in early stages

Evaluating its change over time, CA-125, the protein long-recognized for predicting ovarian cancer recurrence, now shows promise as a screening tool for early-stage disease, according to researchers at The University of Texas MD Anderson Cancer Center.

26 Aug 2013

Athera Transfers Annexin A5 Project To Medirista

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23 Aug 2013

Athera Transfers Annexin A5 Project To Medirista

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23 Aug 2013

Tufts Health Plan provides positive coverage decision and in-network provider status to bioTheranostics

bioTheranostics, a leading provider of molecular diagnostic solutions for cancer, has received a positive coverage decision and in-network provider status from Tufts Health Plan for its CancerTYPE ID molecular cancer classifier.

23 Aug 2013

Board of Directors approve interim report for second quarter 2013

DiaGenic: The interim report for the second quarter 2013 was approved by the Board of Directors on 22 August 2013. Please find the interim report and presentation attached.

23 Aug 2013

Noninvasive urine test can accurately monitor risk of kidney rejection

Levels of a protein in the urine of kidney transplant recipients can distinguish those at low risk of developing kidney injury from those at high risk, a study suggests. The results also suggest that low levels of this protein, called CXCL9, can rule out rejection as a cause of kidney injury.

23 Aug 2013

Mount Sinai, Exosome Partner On Body Fluid Molecular Diagnostics

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22 Aug 2013

Caris Life Sciences to facilitate patient access to tumour profiling service in Middle East and Africa

Caris Life Sciences, a leading biosciences company focused on fulfilling the promise of personalized medicine in oncology, has signed a distribution agreement with IPS Genomix to facilitate patient access to its tumour profiling service, Molecular Intelligence, in select Middle Eastern and African markets.

22 Aug 2013

Majority of Alzheimer's researchers support disclosure of results to study participants

A leading group of Alzheimer's researchers contends that, as biomarkers to detect signals of the disease improve at providing clinically meaningful information, researchers will need guidance on how to constructively disclose test results and track how disclosure impacts both patients and the data collected in research studies.

22 Aug 2013

Biomedical spectroscopy suggests excess copper may be neurotoxic in Alzheimer's patients

Metals such as iron, copper, and zinc are important for many biological processes. In recent years, studies have shown that these nutritionally-essential metals are elevated in human Alzheimer's disease (AD) brains and some animal models of AD. Scientists are now exploring whether these metals are causing the neurodegeneration seen in AD or are indicative of other ongoing pathologic processes.

22 Aug 2013

Oxford Gene Technology releases next generation sequencing survey results

Oxford Gene Technology, provider of innovative genetics research and biomarker solutions to advance molecular medicine, has released the results from a recent survey of researchers using next generation sequencing.

From Oxford Gene Technology 21 Aug 2013

High levels of urinary albumin-to-creatinine ratio linked with greater risk of CHD in black individuals

In a large national study, higher levels of the urinary albumin-to-creatinine ratio was associated with greater risk of incident but not recurrent coronary heart disease in black individuals when compared with white individuals, according to a study in the August 21 issue of JAMA.

21 Aug 2013

Researchers identify key transcription factor linked with treatment-resistant prostate cancer

Prostate cancer is one of the most common forms of cancer in men and the leading cause of cancer deaths in white, African-American and Hispanic men, according to the Centers for Disease Control. Current treatment of prostate cancer targets androgens, hormones which promote the growth and spread of cancer cells.

20 Aug 2013

Biomarker News and Research

Further Reading

Blood test provides tool essential to trials of therapies for Huntington's disease

Blood biomarkers predict suicidality

JCVI Receives $1.25M For Healthy Aging Study

JCVI Receives $1.25M For Healthy Aging Study

Researchers develop ddPCR technology to quantify rejection biomarker in organ transplant injury

ASO may correct striatal transcriptional abnormalities and improve behavioral problems in HD mice

Comprehensive test of biomarkers have prognostic and diagnostic value in Parkinson's disease

CA-125: Screening tool to detect ovarian cancer in early stages

Athera Transfers Annexin A5 Project To Medirista

Athera Transfers Annexin A5 Project To Medirista

Tufts Health Plan provides positive coverage decision and in-network provider status to bioTheranostics

Board of Directors approve interim report for second quarter 2013

Noninvasive urine test can accurately monitor risk of kidney rejection

Mount Sinai, Exosome Partner On Body Fluid Molecular Diagnostics

Caris Life Sciences to facilitate patient access to tumour profiling service in Middle East and Africa

Majority of Alzheimer's researchers support disclosure of results to study participants

Biomedical spectroscopy suggests excess copper may be neurotoxic in Alzheimer's patients

Oxford Gene Technology releases next generation sequencing survey results

High levels of urinary albumin-to-creatinine ratio linked with greater risk of CHD in black individuals

Researchers identify key transcription factor linked with treatment-resistant prostate cancer

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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