Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Study shows human blood contains 1000’s of autoantibodies to clear cellular debris caused by injury, disease

In a study that suggests a new frontier in immunology, scientists at the University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine (UMDNJ-SOM) report on evidence that shows human blood contains thousands of autoantibodies that bind specifically to antigens from organs and tissues all over the body and act to clear cellular debris that results from injury and disease.

10 Apr 2013

CvergenX to develop radiosensitivity test to better radiation therapy decisions for patients with cancer

A molecular signature index technology that can lead to better radiation therapy decisions for patients with cancer is being developed into a reliable radiosensitivity test by CvergenX, Inc., an advanced cancer diagnostics company.

10 Apr 2013

Multiple genes strongly contribute to risk for schizophrenia

Multiple genes contribute to risk for schizophrenia and appear to function in pathways related to transmission of signals in the brain and immunity, according to an international study led by Virginia Commonwealth University School of Pharmacy researchers.

10 Apr 2013

Researchers develop predictive biomarker to identify cancer patients who may respond to autophagy inhibitors

Autophagy, the process by which cells that are starved for food resort to chewing up their own damaged proteins and membranes and recycling them into fuel, has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation.

9 Apr 2013

Exosome profiling of mRNAs and miRNAs in serum samples presented at AACR meeting

Exosome Diagnostics, a leading developer of biofluid-based molecular diagnostics for use in personalized medicine, today announced that the company is presenting a late-breaking abstract at the AACR Annual Meeting 2013, in Washington D.C.

9 Apr 2013

Rheumatoid arthritis blood tests launched by Quest Diagnostics

Quest Diagnostics (NYSE: DGX), the world’s leading provider of diagnostic information services, announced the availability of two new blood tests for aiding the early diagnosis of arthritis (RA), an autoimmune disorder that can cause debilitating joint damage.

From Quest Diagnostics 9 Apr 2013

ISP of Chile approves Trigemina's protocol for Phase 2 clinical study of TI-001

Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products, today announced that the Instituto de Salud Publica of Chile has approved the Company's protocol for its Phase 2 clinical study of TI-001, intranasal oxytocin, for the treatment of chronic migraine.

9 Apr 2013

New study shows exposure to tobacco smoke could negatively impact adolescent kidney function

Exposure to tobacco smoke could negatively impact adolescent kidney function; this is according to a new study led by a team of researchers at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Children's Center.

9 Apr 2013

New drug combination shows anti-cancer activity in patients with solid tumors and germline mutation

A novel combination of two drugs has shown anti-cancer activity in patients who had incurable solid tumors and carried a germline mutation in their BRCA genes, Dana-Farber Cancer Institute researchers are reporting at the American Association for Cancer Research annual meeting in Washington, April 6-10.

8 Apr 2013

Male smokers with low levels of serum bilirubin are at higher risk for lung cancer

Elevated levels of bilirubin in the blood get attention in the clinic because they often indicate that something has gone wrong with the liver. Now researchers have found that male smokers with low levels of the yellow-tinged chemical are at higher risk for lung cancer and dying from the disease.

8 Apr 2013

GE Healthcare releases next-generation sequencing assay for use in clinical trials

GE Healthcare announced today that Clarient Diagnostic Services, Inc., a GE Healthcare company, will begin offering a next-generation sequencing assay focused on solid tumor targets for use in clinical trials.

8 Apr 2013

MentisCura launches clinical center for early detection of Alzheimer's disease, dementia

MentisCura Diagnostics today announced the launch of its first clinical center for the early detection of Alzheimer's disease and other dementias.

8 Apr 2013

Berg to present new findings on cancer treatment, Interrogative Biology Platform at AACR meeting

Berg - a biopharmaceutical company committed to uncovering health solutions through a data-driven, biological research approach - announced today that it will be presenting four abstracts at the AACR Annual Meeting 2013, in Washington, D.C.

8 Apr 2013

SiDMAP announces publication of Isotopolome Wide Association Study in FASEB Journal

SiDMAP, LLC, a leading provider of metabolic profiling and biomarker development services to the pharmaceutical, academic, governmental, and biotechnology industries, announced today the publication of its 13C Isotopolome Wide Association Study matrix in the official journal of the Federation of American Societies for Experimental Biology in collaboration with scientists at the University Of Utah School Of Medicine.

6 Apr 2013

Studies, search for genetic risk factors needed to predict individual's risk for traumatic brain injury

One of the most controversial topics in neurology today is the prevalence of serious permanent brain damage after traumatic brain injury. Long-term studies and a search for genetic risk factors are required in order to predict an individual's risk for serious permanent brain damage, according to a review article published by Sam Gandy, MD, PhD, from the Icahn School of Medicine at Mount Sinai in a special issue of Nature Reviews Neurology dedicated to TBI.

6 Apr 2013

One cohort of Phase 2 NSCLC study fails to meet primary endpoint, Merrimack says

Merrimack Pharmaceuticals, Inc. today announced that one cohort of a Phase 2 non-small cell lung cancer study did not meet its primary endpoint. The cohort evaluated MM-121 in combination with erlotinib to treat patients with NSCLC whose disease progressed on an anti-EGFR tyrosine kinase inhibitor (EGFR-TKI).

5 Apr 2013

Molecular diagnostic testing in lung cancer offers new hope for patients

The emergence of molecular diagnostic testing in lung cancer offers new hope for patients battling the number one cancer killer in the United States and abroad.

4 Apr 2013

Researchers predict probability of cardiovascular risk

Researchers at the Charité - Universitätsmedizin Berlin have managed to predict the probability of a cardiovascular patient suffering a heart attack, stroke or arterial occlusion within three months.

4 Apr 2013

PARP inhibitors can be novel treatment strategy for cisplatin-resistant cancer

Poly (ADP-ribose) polymerase inhibitors may be a novel treatment strategy for patients with cancer that has become resistant to the commonly used chemotherapy drug cisplatin, according to data from a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research.

3 Apr 2013

Penn neurosurgeons use diffusion tensor imaging to better adapt brain tumor surgeries

Neurosurgeons can visualize important pathways in the brain using an imaging technique called diffusion tensor imaging (DTI), to better adapt brain tumor surgeries and preserve language, visual and motor function while removing cancerous tissue.

2 Apr 2013

Biomarker News and Research

Further Reading

Study shows human blood contains 1000’s of autoantibodies to clear cellular debris caused by injury, disease

CvergenX to develop radiosensitivity test to better radiation therapy decisions for patients with cancer

Multiple genes strongly contribute to risk for schizophrenia

Researchers develop predictive biomarker to identify cancer patients who may respond to autophagy inhibitors

Exosome profiling of mRNAs and miRNAs in serum samples presented at AACR meeting

Rheumatoid arthritis blood tests launched by Quest Diagnostics

ISP of Chile approves Trigemina's protocol for Phase 2 clinical study of TI-001

New study shows exposure to tobacco smoke could negatively impact adolescent kidney function

New drug combination shows anti-cancer activity in patients with solid tumors and germline mutation

Male smokers with low levels of serum bilirubin are at higher risk for lung cancer

GE Healthcare releases next-generation sequencing assay for use in clinical trials

MentisCura launches clinical center for early detection of Alzheimer's disease, dementia

Berg to present new findings on cancer treatment, Interrogative Biology Platform at AACR meeting

SiDMAP announces publication of Isotopolome Wide Association Study in FASEB Journal

Studies, search for genetic risk factors needed to predict individual's risk for traumatic brain injury

One cohort of Phase 2 NSCLC study fails to meet primary endpoint, Merrimack says

Molecular diagnostic testing in lung cancer offers new hope for patients

Researchers predict probability of cardiovascular risk

PARP inhibitors can be novel treatment strategy for cisplatin-resistant cancer

Penn neurosurgeons use diffusion tensor imaging to better adapt brain tumor surgeries

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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