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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.
Researchers develop new way to test strength of immune response

Researchers develop new way to test strength of immune response

The immune system orchestrates large and small scale attacks on innumerous targets: viruses, bacteria, cancer, but it also misfires causing allergy or autoimmune reactions. [More]
Yale researchers use new gene editing technique to correct mutations that cause thalassemia

Yale researchers use new gene editing technique to correct mutations that cause thalassemia

A Yale-led research team used a new gene editing strategy to correct mutations that cause thalassemia, a form of anemia. [More]
Researchers identify negative role of oxidation in new blood cells

Researchers identify negative role of oxidation in new blood cells

Oxygen in the air is well known to cause damaging rust on cars through a process known as oxidation. [More]
Novel ‘gene therapy in a box’ could effectively deliver modified blood stem cells

Novel ‘gene therapy in a box’ could effectively deliver modified blood stem cells

A table-top device that enables medical staff to genetically manipulate a patient's blood to deliver potential new therapies for cancer, HIV and other diseases would eliminate the need for multi-million-dollar "clean rooms," making gene therapy more possible for even the poorest of countries. [More]
Novel lipid-based therapeutic shows promise for combating drug resistance in AML

Novel lipid-based therapeutic shows promise for combating drug resistance in AML

Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered a mechanism that confers resistance to drugs used to treat certain types of acute myeloid leukemia (AML). [More]
New oncogene may contribute to high incidence of prostate cancer among African American men

New oncogene may contribute to high incidence of prostate cancer among African American men

A team of scientists has identified MNX1 as a new oncogene - a gene than can cause cancer - that is more active in African American prostate cancer than in European American prostate cancer. [More]
Yale researchers develop new mouse model to understand multiple myeloma

Yale researchers develop new mouse model to understand multiple myeloma

Understanding how multiple myeloma develops and responds to therapies may be easier using a new mouse model developed at Yale University School of Medicine. [More]
Study reveals promising new strategy to treat birth defect in boys

Study reveals promising new strategy to treat birth defect in boys

A study published in Scientific Reports describes a potential new strategy that may be utilized to correct hypospadias, a birth defect which occurs when boys are born with a urinary opening on the underside of the penis, found in up to one in every 200 boys. [More]
Finnish researchers identify molecular mechanism that controls migration of early macrophages

Finnish researchers identify molecular mechanism that controls migration of early macrophages

Leukocytes which arise during the embryonic period regulate iron metabolism and the growth of the mammary gland in adults. [More]
Penn researchers identify new immune system mechanism to fight against infections

Penn researchers identify new immune system mechanism to fight against infections

The innate immune system serves as a first-line defense, responding to infections almost immediately after a pathogen makes its way into the body. [More]
Cleveland Clinic cancer researchers receive $2.4 million grant from NIH NHLBI

Cleveland Clinic cancer researchers receive $2.4 million grant from NIH NHLBI

The National Institutes of Health National Heart, Lung and Blood Institute has awarded a $2.4 million grant over four years to Cleveland Clinic cancer researchers Jaroslaw Maciejewski, M.D., and Richard Padgett, Ph.D., to test the hypothesis that alterations in the pattern of splicing of target genes play a major role in the establishment or progression of myelodysplastic syndromes (MDS). [More]
Mount Sinai awarded $10 million grant to explore cellular, molecular mechanisms of GVHD

Mount Sinai awarded $10 million grant to explore cellular, molecular mechanisms of GVHD

Researchers from the Icahn School of Medicine at Mount Sinai have been awarded a $10 million from the National Cancer Institute to explore the cellular and molecular mechanisms of acute graft-versus-host disease (GVHD), a common side effect that occurs after allogeneic bone marrow transplantation (BMT), and to develop novel therapeutic strategies for BMT patients with cancer that begin in the cells of blood-forming tissue or hematologic malignancies. [More]
Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of affected patients. [More]
Study finds new therapeutic target to prevent progression of rare blood cancer

Study finds new therapeutic target to prevent progression of rare blood cancer

In a laboratory study, Upstate Medical University researcher Golam Mohi, Ph.D., his graduate student Yue Yang, and colleagues, have found that the loss of gene EZH2 promotes the development of Myelofibrosis (MF) in mice. [More]
JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

Seventy-five percent of patients with moderate to severe alopecia areata--an autoimmune disease that causes patchy, and less frequently, total hair loss--had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center. By the end of their treatment, average hair regrowth was 92 percent. [More]
Researchers discover how signals from infectious bacteria get to inflammasome sensors

Researchers discover how signals from infectious bacteria get to inflammasome sensors

Researchers at St. Jude Children's Research Hospital have discovered the way signals from infectious bacteria gain entry into the cytoplasm of host cells to activate disease-fighting inflammasomes. [More]
Researchers identify new immune cell that protects mice from lung infections during chemotherapy

Researchers identify new immune cell that protects mice from lung infections during chemotherapy

St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy. [More]
JAK inhibitors may be first effective treatment for people with alopecia areata

JAK inhibitors may be first effective treatment for people with alopecia areata

Seventy-five percent of patients with moderate to severe alopecia areata—an autoimmune disease that causes patchy, and less frequently, total hair loss—had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center. By the end of their treatment, average hair regrowth was 92 percent. [More]
Novel immunotherapy shows promise against AML in clinical trial

Novel immunotherapy shows promise against AML in clinical trial

A new type of immunotherapy shows promise against cases of acute myeloid leukemia (AML) that recur after treatment or that never respond to therapy in the first place. [More]
New mobile health app may help manage hydroxyurea treatments in sickle cell patients

New mobile health app may help manage hydroxyurea treatments in sickle cell patients

The National Heart, Lung, and Blood Institute, part of the National Institutes of Health, has awarded a 6-year, $4.4 million grant to St. Jude Children's Research Hospital and collaborators to improve the use of prescribed medication by sickle cell patients. [More]
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