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Calcium, the most abundant mineral in the body, is found in some foods, added to others, available as a dietary supplement, and present in some medicines (such as antacids). Calcium is required for muscle contraction, blood vessel expansion and contraction, secretion of hormones and enzymes, and transmitting impulses throughout the nervous system. The body strives to maintain constant concentrations of calcium in blood, muscle, and intercellular fluids, though less than <1% of total body calcium is needed to support these functions.

The remaining 99% of the body's calcium supply is stored in the bones and teeth where it supports their structure. Bone itself undergoes continuous remodeling, with constant resorption and deposition of calcium into new bone. The balance between bone resorption and deposition changes with age. Bone formation exceeds resorption in growing children, whereas in early and middle adulthood both processes are relatively equal. In aging adults, particularly among postmenopausal women, bone breakdown exceeds formation, resulting in bone loss that increases the risk of osteoporosis over time.
New player in calcium signalling pathways acts as molecular brake to Orai activation

New player in calcium signalling pathways acts as molecular brake to Orai activation

Information flow in cells relies on calcium as a key agent in several signalling pathways. Calcium dependent signalling is crucial in nearly every aspect of life - muscle movement, immune reactions, nerve function, light sensing and many such processes. [More]
RBFOX2 dysregulation may cause heart damage in diabetic patients

RBFOX2 dysregulation may cause heart damage in diabetic patients

Cardiac complications are the number one cause of death among diabetics. Now a team of scientists has uncovered a molecular mechanism involved in a common form of heart damage found in people with diabetes. [More]
Researchers identify trigger for immune cells' inflammatory response

Researchers identify trigger for immune cells' inflammatory response

Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response - a discovery that may pave the way for new treatments for many human diseases. [More]
Tips for improving cardiovascular health

Tips for improving cardiovascular health

New research by UT Southwestern heart specialists shows that sedentary behavior such as sitting for long periods of time at a desk or on the couch is associated with increased amounts of calcium in the arteries, which in turn can lead to higher risk of heart attack. [More]
New experimental model may predict eventual cardiac phenotype in pediatric patients

New experimental model may predict eventual cardiac phenotype in pediatric patients

An experimental model uses genetics-guided biomechanics and patient-derived stem cells to predict what type of inherited heart defect a child will develop, according to authors of a new study in the journal Cell. [More]
More than 7 in 10 older hip fracture patients not aware of having osteoporosis

More than 7 in 10 older hip fracture patients not aware of having osteoporosis

More than 7 in 10 older adults who suffer hip fractures aren't told they have the bone-weakening disease osteoporosis - despite the fact that hip fractures nearly always signify the presence of this potentially debilitating condition, according to revealing new research by Northwell Health physicians. [More]
New research defies earlier belief that calcium channels function independently

New research defies earlier belief that calcium channels function independently

Voltage-gated calcium channels open in unison, rather than independently, to allow calcium ions into and activate excitable cells such as neurons and muscle cells, researchers with UC Davis Health System and the University of Washington have found. [More]
Domestic water hardness linked to eczema risk in children

Domestic water hardness linked to eczema risk in children

High levels of water hardness in the home may be linked to the development of eczema early in life, according to a new study led by King's College London. [More]
Take complementary medicines with care

Take complementary medicines with care

Following the broadcast of the ABC’s Four Corners episode last night on complementary medicines, NPS MedicineWise is reminding people to take these medicines with care. [More]
BetterYou Magnesium Oil spray relieves migraine pain in 43-year old mum

BetterYou Magnesium Oil spray relieves migraine pain in 43-year old mum

A 43-year old mum of one from Bristol, who suffered from frequent painful migraines for almost a decade has found relief thanks to BetterYou™ Magnesium Oil spray. [More]
General anesthesia affects heart muscle proteins and causes depressed heart function, study shows

General anesthesia affects heart muscle proteins and causes depressed heart function, study shows

Anesthesia is used every day, but surprisingly little is known about one of its most dangerous side effects--depressed heart function. [More]
Benefits of calcium supplements in preventing broken bones may be cancelled out by increased stroke risk

Benefits of calcium supplements in preventing broken bones may be cancelled out by increased stroke risk

Taking calcium and vitamin D can help prevent broken bones in older women. However, this benefit may be cancelled out by an increased risk of heart attack and stroke. [More]
Controlling heart cells using a laser: an interview with Prof. Konstantin Agladze

Controlling heart cells using a laser: an interview with Prof. Konstantin Agladze

We control their electrical activity. Cardiac cells are capable of producing and transmitting electric signals through changes in a cell membrane potential. [More]
T cell gives precise mechanical tugs to detect friends and foes

T cell gives precise mechanical tugs to detect friends and foes

T cells, the security guards of the immune system, use a kind of mechanical "handshake" to test whether a cell they encounter is a friend or foe, a new study finds. [More]
ITJ researchers develop new hydrating beverage for athletes

ITJ researchers develop new hydrating beverage for athletes

Jiquiquilpan's Institute of Technology in Mexico developed a hydrating beverage for athletes that is based on agave's fructans, that not only supplies the adequate water levels to the organisms, but also offers other benefits such as dietetic fiber. [More]
Blend of pulverized natural bone and man-made plastic can create 3D printed replacement bones

Blend of pulverized natural bone and man-made plastic can create 3D printed replacement bones

To make a good framework for filling in missing bone, mix at least 30 percent pulverized natural bone with some special man-made plastic and create the needed shape with a 3-D printer. That's the recipe for success reported by researchers at The Johns Hopkins University in a paper published April 18 online in ACS Biomaterials Science & Engineering. [More]
Bayer-new phase 3 liver cancer data

Bayer-new phase 3 liver cancer data

Bayer has announced that a Phase III trial evaluating its oncology compound Stivarga® (regorafenib) tablets for the treatment of patients with unresectable hepatocellular carcinoma (HCC) has met its primary endpoint of a statistically significant improvement in overall survival. The study, called RESORCE, evaluated the efficacy and safety of regorafenib in patients with HCC whose disease has progressed after treatment with sorafenib. The safety and tolerability were generally consistent with the known profile of regorafenib. Detailed efficacy and safety analyses from this study are expected to be presented at an upcoming scientific congress. [More]
Researchers discover critical new mechanism for genesis of heart failure

Researchers discover critical new mechanism for genesis of heart failure

A weak heart is unable to pump an adequate amount of blood around the body. In Germany, this condition is now the commonest reason for patients to be admitted to hospital. [More]
Novel gene therapy can treat pulmonary hypertension linked with heart failure

Novel gene therapy can treat pulmonary hypertension linked with heart failure

Scientists have used a novel gene therapy to halt the progression of pulmonary hypertension, a form of high blood pressure in the lung blood vessels that is linked to heart failure, according to a study led by Roger J. Hajjar, MD, Professor of Medicine and Director of the Cardiovascular Research Center at the Icahn School of Medicine at Mount Sinai. [More]
First generic version of Crestor gets FDA approval

First generic version of Crestor gets FDA approval

The U.S. Food and Drug Administration today approved the first generic version of Crestor (rosuvastatin calcium) tablets. [More]
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