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Stem cell-based epilepsy approach may help in search for better medicines to treat seizure disorders

A new stem cell-based approach to studying epilepsy has yielded a surprising discovery about what causes one form of the disease, and may help in the search for better medicines to treat all kinds of seizure disorders.

25 Jul 2013

Researchers find that Notch signaling elevated in tumors relative to normal bone

Many cancers show inappropriate activation of a cell signaling pathway called NOTCH. In the developing body, NOTCH tells brain cells to grow and proliferate. It should be quiet in the adult body, but cancers restart NOTCH to drive their own growth, far and beyond the rate of healthy tissues.

25 Jul 2013

Mda-9/syntenin helps regulate bladder cancer growth and metastasis

Scientists from Virginia Commonwealth University Massey Cancer Center have provided evidence from preclinical experiments that a gene known as melanoma differentiation associated gene-9/syntenin (mda-9/syntenin) could be used as a therapeutic target to kill bladder cancer cells, help prevent metastasis and even be used to non-invasively diagnose the disease and monitor its progression.

25 Jul 2013

Discovery could lead to new therapeutic strategy for Parkinson's disease

Biologists at The Scripps Research Institute (TSRI) have made a significant discovery that could lead to a new therapeutic strategy for Parkinson's disease.

25 Jul 2013

Researchers identify key molecular pathways that lead to late-onset Alzheimer's disease

Key molecular pathways that ultimately lead to late-onset Alzheimer's disease, the most common form of the disorder, have been identified by researchers at Columbia University Medical Center (CUMC).

25 Jul 2013

Scientists identify new genetic mutations that can cause pulmonary arterial hypertension

Columbia University Medical Center (CUMC) scientists have identified new genetic mutations that can cause pulmonary arterial hypertension (PAH), a rare fatal disease characterized by high blood pressure in the lungs.

25 Jul 2013

Faulty genetic pathway is a potent player in many types of allergies, say researchers

Newly published research by investigators at the Johns Hopkins Children's Center and the Johns Hopkins Institute of Genetic Medicine reveals that a faulty genetic pathway already known for its role in some connective tissue disorders is also a potent player in many types of allergies.

25 Jul 2013

Verastem's defactinib gets FDA orphan drug designation for treatment of mesothelioma

Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced that lead cancer stem cell inhibitor, VS-6063 (defactinib), has received orphan drug designation from the U.S. Food and Drug Administration for use in the treatment of mesothelioma, a rare form of lung cancer.

24 Jul 2013

OracleBio to highlight Oncology image analysis expertise at Tumor Models conference

OracleBio, providers of high precision digital image analysis services for detailed quantification of histological marker staining within cells and tissues, is pleased to announce it will be a principal sponsor of the forthcoming Tumor Models conference to be held in Boston, MA on the 23-25th July.

24 Jul 2013

UL researcher receives €1.5 million to develop innovative treatments for bone-loss diseases

UL researcher, Dr David Hoey was announced as one of the recipients of the highly prestigious European Research Council (ERC) starting grants. Dr Hoey has been awarded €1.5 million to pursue cutting-edge fundamental research into developing innovative treatments for bone-loss diseases such as osteoporosis. Every 30 seconds a person suffers an osteoporosis-related hip fracture in the EU.

24 Jul 2013

Child cancer survival: an interview with Prof Kathy Pritchard-Jones, University College London

Back in the early 1960s, just before chemotherapy really started to be used, only about 30% of children survived cancer. That was mainly because they had cancers that were amenable to surgery.

24 Jul 2013

Inovio plans to advance synthetic hTERT cancer vaccine into clinical trials in 2014

Inovio Pharmaceuticals, Inc. announced today that in a preclinical study with two animal models, Inovio's hTERT (human telomerase reverse transcriptase) DNA cancer vaccine administered with Inovio's CELLECTRA adaptive electroporation delivery technology generated robust and broad immune responses, broke the immune system's tolerance to its self-antigens, induced T-cells with a tumor-killing function, and increased the rate of survival.

24 Jul 2013

3-D hydrogel approach to study aggressive and deadly forms of brain cancer

Human glioblastoma multiforme, one of the most common, aggressive and deadly forms of brain cancer, is notoriously difficult to study. Scientists have traditionally studied cancer cells in petri dishes, which have none of the properties of the brain tissues in which these cancers grow, or in expensive animal models.

24 Jul 2013

Researchers discover mechanism that prevents immune system from spinning out of control

A team led by a University of Arizona researcher has discovered a previously unknown mechanism that prevents the immune system from going into overdrive, shedding light not only on how our body controls its response to pathogens but on conditions such as autoimmune diseases, allergies and chronic inflammation as well.

24 Jul 2013

Findings open new perspectives for research on proteins that control metastasis

In experiments on zebrafish, Freiburg researchers have demonstrated that the same proteins that lead to the formation of metastases in humans also cause the cells to migrate during embryonic development.

24 Jul 2013

Platelet activation inhibits host cell entry of HIV, shows research

Scientists of the DPZ have shown that platelet activation inhibits the host cell entry of HIV. Infection biologists of the German Primate Center (DPZ) under the direction of Stefan Pöhlmann have found evidence that platelets (thrombocytes) might constitute an innate defense against infection with the human immunodeficiency virus (HIV).

24 Jul 2013

Research team receives NCI grant to develop precision therapies that kill cancer cells

A research team headed by Fred Hutchinson Cancer Research Center scientists Christopher Kemp, Ph.D., and Carla Grandori, M.D., Ph.D., has received a $4 million grant from the National Cancer Institute to develop precision therapies that selectively kill cancer cells while sparing normal, healthy tissue.

24 Jul 2013

Scientists reveal new images of how white blood immune cells attack tumours, viral infections

Scientists from The University of Manchester have revealed new images which provide the clearest picture yet of how white blood immune cells attack viral infections and tumours.

From The University of Manchester 24 Jul 2013

Genentech announces that Phase III CLL11 study meets primary endpoint

Genentech, a member of the Roche Group, today announced positive results from the Phase III CLL11 study. At a pre-planned interim analysis, an independent data monitoring committee determined that the study met its primary endpoint showing that GA101 plus chlorambucil helped people live significantly longer without their disease worsening (progression-free survival; PFS) compared to Rituxan (rituximab) plus chlorambucil.

24 Jul 2013

Astrocytes can protect brain tissue and reduce disability due to stroke

One of regenerative medicine's greatest goals is to develop new treatments for stroke. So far, stem cell research for the disease has focused on developing therapeutic neurons - the primary movers of electrical impulses in the brain - to repair tissue damaged when oxygen to the brain is limited by a blood clot or break in a vessel. New UC Davis research, however, shows that other cells may be better suited for the task.

24 Jul 2013

Cell News and Research

Stem cell-based epilepsy approach may help in search for better medicines to treat seizure disorders

Researchers find that Notch signaling elevated in tumors relative to normal bone

Mda-9/syntenin helps regulate bladder cancer growth and metastasis

Discovery could lead to new therapeutic strategy for Parkinson's disease

Researchers identify key molecular pathways that lead to late-onset Alzheimer's disease

Scientists identify new genetic mutations that can cause pulmonary arterial hypertension

Faulty genetic pathway is a potent player in many types of allergies, say researchers

Verastem's defactinib gets FDA orphan drug designation for treatment of mesothelioma

OracleBio to highlight Oncology image analysis expertise at Tumor Models conference

UL researcher receives €1.5 million to develop innovative treatments for bone-loss diseases

Child cancer survival: an interview with Prof Kathy Pritchard-Jones, University College London

Inovio plans to advance synthetic hTERT cancer vaccine into clinical trials in 2014

3-D hydrogel approach to study aggressive and deadly forms of brain cancer

Researchers discover mechanism that prevents immune system from spinning out of control

Findings open new perspectives for research on proteins that control metastasis

Platelet activation inhibits host cell entry of HIV, shows research

Research team receives NCI grant to develop precision therapies that kill cancer cells

Scientists reveal new images of how white blood immune cells attack tumours, viral infections

Genentech announces that Phase III CLL11 study meets primary endpoint

Astrocytes can protect brain tissue and reduce disability due to stroke

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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