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Researchers pinpoint role of Arl13b gene in guiding placement of neurons during brain development

Researchers have pinpointed the role of a gene known as Arl13b in guiding the formation and proper placement of neurons in the early stages of brain development. Mutations in the gene could help explain brain malformations often seen in neurodevelopmental disorders.

3 Jul 2013

NIDA grants $3.3M to design vaccine conferring immunity to nicotine

A chemical component present in the nightshade family of plants is one of the world's most tenaciously addictive substances. It is the nicotine contained in tobacco and found in high concentrations in cigarettes. Smoking remains a global scourge; in the U.S. it is the leading source of preventable death.

3 Jul 2013

Activation of brown fat increases heart-related mortality during winter

More people die from heart-disease during the winter months, and according to a new study published in the journal Cell Metabolism, the increase in mortality is possibly due to the accelerated growth of atherosclerotic plaque in the blood vessels caused by the activation of brown fat by the cold.

3 Jul 2013

Researchers find NRF2 signaling plays a role in growth of tumor cells by altering metabolic pathways

Cancer cells have alteration in metabolic pathways as a result of oncogenes that promote tumor growth. NRF2 (nuclear factor erythroid-derived 2-related factor 2) works as a "master gene" that turns on stress response by increasing numerous antioxidants and pollutant-detoxifying genes to protect the lungs from variety of air pollutants such as diesel exhaust and cigarette smoke.

3 Jul 2013

Ubiquitin protein may treat variety of diseases from Parkinson's to diabetes

A tiny protein called ubiquitin - so named because it is present in every cell of living things as dissimilar as hollyhocks and humans - may hold the key to treatment for a variety of diseases from Parkinson's to diabetes.

3 Jul 2013

Array BioPharma achieves milestone for initiation of MEK162 Phase 3 trial in patients with LGSOC

Array BioPharma Inc. announced today that a $5 million milestone was achieved after the start of Array's Phase 3 clinical trial in patients with low-grade serous ovarian cancer.

2 Jul 2013

Alnylam Pharmaceuticals presents new pre-clinical data of ALN-AT3 at ISTH meeting

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data from its RNAi therapeutic program for the treatment of hemophilia and rare bleeding disorders.

2 Jul 2013

UCLA researchers introduce gene therapy technique to treat sickle cell disease

Researchers at UCLA's Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research have successfully established the foundation for using hematopoietic (blood-producing) stem cells from the bone marrow of patients with sickle cell disease to treat the disease.

2 Jul 2013

UH and Case Western Reserve University to develop diagnostic tests to determine HIV drug resistance

Case Western Reserve University has signed an exclusive worldwide licensing agreement granting University Hospitals Case Medical Center rights to a series of diagnostic tests to determine drug resistance and co-receptor tropism in human immunodeficiency virus.

2 Jul 2013

Scientists find new links in gene networks that control movement

The idea that worms can be seen as waveforms allowed scientists at Rice University to find new links in gene networks that control movement.

2 Jul 2013

Study offers new insights into how genome gets regulated by signalling molecules within human cells

There's not much difference between what makes a man and what makes his beer - at least at the molecular level - according to a new study led by Professor John Schwabe at the University of Leicester.

2 Jul 2013

Osteoarthritis associated genes: an interview with Professor Jonathan Tobias, University of Bristol

Joints are lined by articular cartilage, loss of which is one of the hallmarks of osteoarthritis. Articular cartilage is made up of a number of proteins, such as type II collagen. In rare forms of osteoarthritis, one of these structural proteins is defective as a result of a genetic mutation.

2 Jul 2013

Key to treating neurodegenerative prion diseases may lie in ribosome, shows research

New research results from Uppsala University, Sweden, show that the key to treating neurodegenerative prion diseases such as mad cow disease and Creutzfeldt-Jakob disease may lie in the ribosome, the protein synthesis machinery of the cell. The results were recently published in the Journal of Biological Chemistry.

2 Jul 2013

UVA researchers identify promising target for treating glioblastoma

Researchers at the University of Virginia Cancer Center have identified a promising target for treating glioblastoma, one that appears to avoid many of the obstacles that typically frustrate efforts to develop effective treatments for this deadliest of cancers.

2 Jul 2013

Fondation Leducq grants $6M to cardiovascular scientists to help advance cardiac regeneration therapeutics

The Fondation Leducq in Paris, France, dedicated to improving human health through international efforts to combat cardiovascular disease, awarded a $6 million grant award to a new global research network of cardiovascular scientists which includes three researchers from the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai.

2 Jul 2013

New mechanism triggers chronic inflammation in Alzheimer's, atherosclerosis and type-2 diabetes

Researchers at NYU Langone Medical Center have discovered a mechanism that triggers chronic inflammation in Alzheimer's, atherosclerosis and type-2 diabetes. The results, published today in Nature Immunology, suggest a common biochemical thread to multiple diseases and point the way to a new class of therapies that could treat chronic inflammation in these non-infectious diseases without crippling the immune system.

2 Jul 2013

UCSF researchers find that vitamin C may help stem cells, in vitro fertilization

Vitamin C affects whether genes are switched on or off inside mouse stem cells, and may thereby play a previously unknown and fundamental role in helping to guide normal development in mice, humans and other animals, a scientific team led by UC San Francisco researchers has discovered.

2 Jul 2013

Scientists track down origins of fibrosis-promoting cells that scar and destroy organs

Scientists have tracked down and quantified the diverse origins of cells that drive fibrosis, the incurable, runaway wound-healing that scars and ultimately destroys organs such as the lungs, liver and kidneys.

2 Jul 2013

Researchers discover role of TonB bacterial protein that causes various diseases

A Kansas State University-led study has discovered the role of a protein in bacteria that cause a wide variety of diseases, including typhoid fever, plague, meningitis and dysentery. The results may lead to new and improved antibiotics for humans and animals.

2 Jul 2013

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

It's a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.

2 Jul 2013

Cell News and Research

Researchers pinpoint role of Arl13b gene in guiding placement of neurons during brain development

NIDA grants $3.3M to design vaccine conferring immunity to nicotine

Activation of brown fat increases heart-related mortality during winter

Researchers find NRF2 signaling plays a role in growth of tumor cells by altering metabolic pathways

Ubiquitin protein may treat variety of diseases from Parkinson's to diabetes

Array BioPharma achieves milestone for initiation of MEK162 Phase 3 trial in patients with LGSOC

Alnylam Pharmaceuticals presents new pre-clinical data of ALN-AT3 at ISTH meeting

UCLA researchers introduce gene therapy technique to treat sickle cell disease

UH and Case Western Reserve University to develop diagnostic tests to determine HIV drug resistance

Scientists find new links in gene networks that control movement

Study offers new insights into how genome gets regulated by signalling molecules within human cells

Osteoarthritis associated genes: an interview with Professor Jonathan Tobias, University of Bristol

Key to treating neurodegenerative prion diseases may lie in ribosome, shows research

UVA researchers identify promising target for treating glioblastoma

Fondation Leducq grants $6M to cardiovascular scientists to help advance cardiac regeneration therapeutics

New mechanism triggers chronic inflammation in Alzheimer's, atherosclerosis and type-2 diabetes

UCSF researchers find that vitamin C may help stem cells, in vitro fertilization

Scientists track down origins of fibrosis-promoting cells that scar and destroy organs

Researchers discover role of TonB bacterial protein that causes various diseases

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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