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Porvair Sciences to improve the diagnosis and treatment of ovarian cancer

Porvair Sciences reports on its involvement in a new £2.6 million project led by Swansea University (UK) that aims to dramatically improve the diagnosis and treatment of ovarian cancer.

From Chromatrap® - Porvair Sciences Ltd 27 Feb 2019

Novel mechanism behind DNA damage control uncovered

DNA damage is occurring in our cells all the time due to external agents, such as exposure to sun, or internal agents, like reactive oxygen species.

26 Feb 2019

Study shows how 3D organization of genetic material helps perpetuate the species

From fathers to children, the delivery of hereditary information requires the careful packing of DNA in sperm. But just how nature packages this DNA to prepare offspring isn't clear.

19 Feb 2019

Study discovers new therapy for aggressive blood cancer

Acute myeloid leukemia is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells.

13 Feb 2019

Super-resolution microscopy could help better study single cells

For a better understanding of biological processes, researchers need to be able to ‘see’ the smallest components of individual cells, such as DNA, mRNA and proteins.

12 Feb 2019

Study: BldC protein in Streptomyces acts as ‘brake’ to control timing of sporulation

Streptomyces are soil-dwelling bacteria that produce approximately two-thirds of the antibiotics in current clinical use.

6 Feb 2019

New autism mouse model shows how epigenetic regulation impacts downstream gene

The causes of autism spectrum disorder are diverse and to some extent, unknown. But without doubt, they are complex, layered and deeply nuanced.

31 Jan 2019

Chromatrap partners with Covaris to offer highly scalable and simple ChIP workflow

Chromatrap has entered into a partnership with Covaris to offer a highly scalable and simple ChIP workflow enabling researchers to easily isolate protein-DNA complexes for downstream applications, such as ChIP-Seq, ChIP-qPCR, Next-generation sequencing, and Mass Spectrometry.

From Chromatrap® - Porvair Sciences Ltd 30 Jan 2019

New approach identifies epigenetic changes in leukemia cells for patients undergoing ibrutinib treatment

Many new anti-cancer drugs inhibit proteins that are essential for the proliferation of cancer cells. One example is ibrutinib, an innovative therapy for chronic lymphocytic leukemia first approved in 2014.

29 Jan 2019

EZH2 mutations can be used as marker for diagnosing different types of cancers

Inside the cell, DNA is tightly wrapped around proteins and packed in a complex, 3D structure that we call "chromatin".

29 Jan 2019

Researchers uncover new role of heterochromatin in maintaining chromosomal integrity

Although many people are aware that chromosomal damage and shortening contribute to the aging process, understanding how chromosomal defects occur is about more than just finding a way to turn back the clock. Large changes in the structure of chromosomes, known as gross chromosomal rearrangements, can result in cell death or genetic diseases such as cancer.

24 Jan 2019

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Using a new epigenetics-based approach, scientists have managed to reduce memory loss and improve cognitive function in a mouse model of Alzheimer’s disease.

22 Jan 2019

Conducting ChIP-Seq with Low Cell Numbers

An interview with Dr. Kathyrn Cunningham at SfN 2018, providing advice on carrying out Chromatin Immunoprecipitation Sequencing (ChIP-seq) with low cell numbers.

From Active Motif 14 Jan 2019

Enhancers can be predicted through ChIP-seq technology

In genetics, an enhancer is a short region of DNA that can be bound by proteins to increase the likelihood that transcription of a particular gene will occur.

23 Dec 2018

New robust method for microscopically profiling tiny single cells

Many of the cell types in our bodies work in obscure ways, that science does not yet fully understand. That also goes for immune cells, which are vital for protecting us against serious diseases.

17 Dec 2018

Chromatrap buffer reagents for lysing cells offer many benefits

Porvair Sciences announce how its Chromatrap Lysis and Hypotonic buffers play a crucial role in enabling researchers to better understand biological organisms.

From Chromatrap® - Porvair Sciences Ltd 13 Dec 2018

New protein complex helps embryonic stem cells to maintain their indefinite potential

Embryonic stem cells (ESCs) are the very definition of being full of potential, given that they can become any type of cell in the body. Once they start down any particular path toward a type of tissue, they lose their unlimited potential.

12 Dec 2018

Mount Sinai researcher awarded $2.5 million to advance understanding of neurodegenerative diseases

Ivan Marazzi, PhD, Assistant Professor of Microbiology at the Icahn School of Medicine at Mount Sinai, was awarded $2.5 million in funding by the Chan Zuckerberg Initiative to further the understanding of the underlying causes of neurodegenerative disorders such as Lou Gehrig's, Alzheimer's, and Parkinson's diseases. The

7 Dec 2018

Light-activated tools allow scientists to accurately probe intracellular phase separation

Creating new tools that harness light to probe the mysteries of cellular behavior, Princeton researchers have made discoveries about the formation of cellular components called membraneless organelles and the key role these organelles play in cells.

30 Nov 2018

Special care should be taken with drugs that inhibit epigenetic factors, study suggests

A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors.

20 Nov 2018