Chromatin News and Research

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New study investigates the epigenetic drift of time passing

A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, "Time makes histone H3 modifications drift in mouse liver."

30 Jun 2022

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Researchers assessed the impact of SARS-CoV-2 envelope protein on the bromodomain and extraterminal domain (BET) proteins.

29 Jun 2022

Scientists discover how to prevent T cell exhaustion to maintain the fight against cancer

When faced with a formidable foe for months on end, the immune system's T cells begin to tire. Whether fighting a cancer or a chronic infection, they become less effective over time, a phenomenon dubbed "T cell exhaustion" by scientists.

28 Jun 2022

New machine learning method may improve the identification of genes that cause diseases

A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers.

28 Jun 2022

New method helps unravel three-dimensional structure of the human genome

Weill Cornell Medicine and New York Genome Center researchers, in collaboration with Oxford Nanopore Technologies, have developed a new method to assess on a large scale the three-dimensional structure of the human genome, or how the genome folds.

23 Jun 2022

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T–cell therapy for treatment of solid tumors.

22 Jun 2022

Researchers map cancer driver mutations across the human genome

In a recent study published in Nature Biotechnology, researchers explored the causes of cancer by mapping somatic mutation rates across the human genome.

22 Jun 2022

New research helps to better understand the basic biology of nerve cells

Scientists are starting to understand the precise workings of a type of gene that, unlike other genes, does not code for proteins – the building blocks of life.

16 Jun 2022

Multiomics identifies genomic risk factors for COVID-19

In a recent Cell Systems study, researchers utilized the RefMap machine learning algorithm to correlate known genomic variations for severe COVID-19 obtained from large-scale genome-wide association studies (GWAS) with single-cell multiome profiling of human lungs.

16 Jun 2022

Diet supplemented with or deficient in methionine affects gene expression related to liver cell fat metabolism

Having shown that diet can influence gene expression, science is starting to find out more about how this happens.

15 Jun 2022

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

A new study that analyzed protein levels in 2,002 primary tumors from 14 tissue-based cancer types identified 11 distinct molecular subtypes, providing systematic knowledge that greatly expands a searchable online database that has become a go-to platform for cancer data analysis by users worldwide.

10 Jun 2022

Steady-state DNA motion allows cells to conduct housekeeping tasks under similar nuclear environments

Researchers in Japan have discovered that the local DNA motion inside of human cells remains steady throughout interphase, where the cell grows and replicates its DNA for cell division.

3 Jun 2022

New findings reveal potential mechanisms for cellular defects in human laminopathies

A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the Proceedings of the National Academy of Sciences.

1 Jun 2022

Discovery of new prostate cancer subtype opens the door to development of therapies

Researchers at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have identified a previously unrecognized form of hormone therapy-resistant prostate cancer, as well as a set of molecules that drive its growth.

27 May 2022

Potential therapeutic target discovered for pancreatic ductal adenocarcinoma tumors

Northwestern Medicine investigators have discovered a potential therapeutic target for the most common type of pancreatic cancer, according to a study published in Developmental Cell.

19 May 2022

A*STAR, NHCS, NUS, and Novo Nordisk partner to study the mechanisms underlying heart failure

The Agency for Science, Technology and Research's Genome Institute of Singapore and Bioinformatics Institute, as well as the National Heart Centre Singapore, National University of Singapore, and pharmaceutical company Novo Nordisk have signed an agreement to study the mechanisms underlying cardiovascular disease progression-; especially the condition called heart failure with preserved ejection fraction (HFpEF).

13 May 2022

Chromatin News and Research

New study investigates the epigenetic drift of time passing

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Scientists discover how to prevent T cell exhaustion to maintain the fight against cancer

New machine learning method may improve the identification of genes that cause diseases

New method helps unravel three-dimensional structure of the human genome

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Researchers map cancer driver mutations across the human genome

New research helps to better understand the basic biology of nerve cells

Multiomics identifies genomic risk factors for COVID-19

Diet supplemented with or deficient in methionine affects gene expression related to liver cell fat metabolism

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

Steady-state DNA motion allows cells to conduct housekeeping tasks under similar nuclear environments

New findings reveal potential mechanisms for cellular defects in human laminopathies

Discovery of new prostate cancer subtype opens the door to development of therapies

Potential therapeutic target discovered for pancreatic ductal adenocarcinoma tumors

A*STAR, NHCS, NUS, and Novo Nordisk partner to study the mechanisms underlying heart failure

Research describes how DNA damage can affect neural health and function

UC Davis researchers identify a protein that keeps Kaposi's sarcoma-associated herpesvirus dormant

COVID-19-induced non-cell-autonomous anosmia

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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