Clinical Trial News and Research

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Peginterferon and Ribavirin combination promising for those with HIV and HCV

Since the introduction of highly active combination drug therapy for HIV, liver failure attributable to infection with the hepatitis C virus (HCV) has become a leading cause of death among those infected with the virus that causes AIDS.

22 Aug 2004

Research will lead to better treatments for mastocytosis

Tens of millions of people know what it's like to suffer the seasonal torment of allergies, when just a whiff of pollen, mold or dust can set off a chain reaction in the body that causes sniffling, sneezing and coughing.

18 Aug 2004

Catheter delivered devices may be just as effective as drug therapy in treating strokes of unidentified origin

A percutaneous catheter procedure to correct a heart abnormality caused by an open patent foramen ovale (PFO), a flap that should be closed in an adult heart, may be just as effective as drug therapy in treating patients who have had strokes of unidentified origin, perhaps caused by this condition.

18 Aug 2004

Mixed effects for vitamin E against respiratory infections

Vitamin E does not appear to have a beneficial effect on lower respiratory tract infections in elderly nursing home residents, but it may help them ward off upper respiratory tract infections, according to a study in the current issue of the Journal of the American Medical Association.

18 Aug 2004

New guidelines urge early and long-term treatment with Aldosterone blockade therapy

Patients who have had a recent heart attack with ST-elevation (ST-Elevation Myocardial Infarction, or STEMI), complicated by heart failure should be treated with aldosterone blockers according to new guidelines issued recently by the American College of Cardiology (ACC) and the American Heart Association (AHA).

17 Aug 2004

Heart pump improves quality of life in congestive heart failure patients

The most seriously ill congestive heart failure patients live longer and have a better quality of life if implanted with a heart pump, researchers report in Circulation: Journal of the American Heart Association.

17 Aug 2004

No adverse side-effects have been observed in clinical trial of SARS vaccine

Sinovac Biotech has announced that all 36 subjects of the Phase I human clinical trial for its inactivated SARS vaccine have now been vaccinated with either SARS vaccine or placebo.

11 Aug 2004

American Indians and Alaska Natives are 2.3 times as likely to have diabetes as non-Hispanic whites of similar age

About 40 percent of adults ages 40 to 74 - or 41 million people - have pre-diabetes, a condition that raises a person's risk of developing type 2 diabetes, heart disease, and stroke.

11 Aug 2004

Clinical trial of lipase inhibitor for the treatment of obesity

Peptimmune, Inc. a privately held biotechnology company, announced that physicians have treated the first participant in a clinical trial to evaluate the safety, tolerability and pharmacokinetics of GT389-255, a lipase inhibitor conjugated to a fat binding polymer for the treatment of obesity.

9 Aug 2004

Effects of oxidative stress on atherosclerosis

Heart disease and stroke are the first and third leading causes of death among men and women in the United States and account for 40 percent of all mortalities, according to the Centers for Disease Control and Prevention.

9 Aug 2004

Approval of Cymbalta for treatment of major depressive disorder

The U.S. Food and Drug Administration has approved Cymbalta® (duloxetine HCl; pronounced SIM-BALL-TA), judging it a safe and effective treatment for major depressive disorder, Eli Lilly and Company have announced.

5 Aug 2004

New screening test for oesophageal (food pipe) cancer

A new screening test for oesophageal (food pipe) cancer could dramatically improve survival from the disease, according to research published in the British Journal of Cancer this week.

5 Aug 2004

Half of the complications and deaths due to in-hospital DVT can be prevented with once daily dalteparin

Current research supports the use of blood-thinners to help acutely ill, hospitalized patients minimize the risk of death from a pulmonary embolism (PE) and its precursor deep vein thrombosis (DVT).

3 Aug 2004

New gene therapy treatment involves injecting Herpes simplex virus into the brain tumours of Glioma patients

Experts on the Gene Therapy Advisory Committee have given the go ahead for a large clinical trial of a new treatment for patients with Glioma - one of the most aggressive types of brain tumours for which there is currently no cure.

3 Aug 2004

Clinical trial established that two drugs, levodopa and pramipexole, are both viable initial treatments for Parkinson's disease

The four-year clinical trial established that two drugs, levodopa and pramipexole, are both viable initial treatments for Parkinson's disease, a degenerative disorder of the central nervous system.

3 Aug 2004

CV Therapeutics initiates approval-enabling trial of drug to treat chronic angina

CV Therapeutics has announced that it has initiated an approval-enabling study of Ranexa, which, if successful, could support approval of Ranexa for the treatment of chronic angina in a restricted patient population.

3 Aug 2004

Metabasis Therapeutics announces multi-center Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate

Metabasis Therapeutics has announced the initiation of a multi-center, multi- national Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate in chronic hepatitis B (HBV) infected patients.

3 Aug 2004

Recommendation against the use of chemotherapy sensitivity and resistance assays

A new technology assessment from the American Society of Clinical Oncology states that the use of chemotherapy sensitivity and resistance assays (CSRAs) to select chemotherapeutic agents for cancer patients should not be undertaken outside of the clinical trial setting.

3 Aug 2004

One-third of U.S. adults use some form of alternative medicine

More than one-third of U.S. adults use some form of alternative medicine such as herbal supplements and other therapies, showed in a nationwide survey by NIH's National Center for Complementary and Alternative Medicine published in May 2004.

2 Aug 2004

Smart gene therapy might effectively prevent the organ damage commonly suffered by heart attack victims

Early intervention with a novel kind of "smart gene therapy" might effectively prevent the organ damage commonly suffered by heart attack victims, suggests a new animal study by researchers at Brigham and Women's Hospital in Boston and Duke University Medical Center.

2 Aug 2004

Clinical Trial News and Research

Peginterferon and Ribavirin combination promising for those with HIV and HCV

Research will lead to better treatments for mastocytosis

Catheter delivered devices may be just as effective as drug therapy in treating strokes of unidentified origin

Mixed effects for vitamin E against respiratory infections

New guidelines urge early and long-term treatment with Aldosterone blockade therapy

Heart pump improves quality of life in congestive heart failure patients

No adverse side-effects have been observed in clinical trial of SARS vaccine

American Indians and Alaska Natives are 2.3 times as likely to have diabetes as non-Hispanic whites of similar age

Clinical trial of lipase inhibitor for the treatment of obesity

Effects of oxidative stress on atherosclerosis

Approval of Cymbalta for treatment of major depressive disorder

New screening test for oesophageal (food pipe) cancer

Half of the complications and deaths due to in-hospital DVT can be prevented with once daily dalteparin

New gene therapy treatment involves injecting Herpes simplex virus into the brain tumours of Glioma patients

Clinical trial established that two drugs, levodopa and pramipexole, are both viable initial treatments for Parkinson's disease

CV Therapeutics initiates approval-enabling trial of drug to treat chronic angina

Metabasis Therapeutics announces multi-center Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate

Recommendation against the use of chemotherapy sensitivity and resistance assays

One-third of U.S. adults use some form of alternative medicine

Smart gene therapy might effectively prevent the organ damage commonly suffered by heart attack victims

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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