Patients who have had a recent heart attack with ST-elevation (ST-Elevation Myocardial Infarction, or STEMI), complicated by heart failure should be treated with aldosterone blockers according to new guidelines issued recently by the American College of Cardiology (ACC) and the American Heart Association (AHA).
The new ACC/AHA STEMI guidelines regarding aldosterone blockade are based in part on the landmark EPHESUS(TM) (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) clinical trial, the results of which were published in The New England Journal of Medicine on April 3, 2003. The EPHESUS(TM) study demonstrated significant survival benefits in post-MI patients with evidence of heart failure.
"The new STEMI guidelines have important implications for improving the care of patients post-myocardial infarction," said Bertram Pitt, MD, Professor of Internal Medicine, University of Michigan Health System. "They emphasize the importance of treating patients with evidence of heart failure following an acute myocardial infarction with an aldosterone blocking agent. The results of EPHESUS clearly show that we can improve mortality as well as the incidence of cardiovascular hospitalization in these patients by adding the aldosterone blocker, eplerenone, to our current treatment strategies."
STEMI is a heart attack causing damage to the heart muscle, recognized on an electrocardiogram by elevation of the ST segment. This injury often leads to weakening of the heart muscle and may result in heart failure. Like all heart attacks, STEMI is associated with an increased risk of cardiac death. An estimated 500,000 STEMI events occur each year in the US. Furthermore, more than 30% of all acute myocardial infarctions (AMIs) are complicated by heart failure.
The new ACA/AHA STEMI guidelines recognize the body of evidence supporting the role of aldosterone blockade in reducing cardiovascular events. Aldosterone blockers received the highest "Class I, Level of Evidence A" endorsement by the Guidelines Committee. Class I means that a treatment should be administered, and Level A means that there is ample clinical evidence to support the administration of the treatment.
The guidelines, published in the current issues of Circulation and the Journal of the American College of Cardiology, recommend that aldosterone blockade therapy be initiated in the hospital and also prescribed for long- term use. Specifically, the guidelines recommend that "long-term aldosterone blockade should be prescribed for post-STEMI patients without significant renal dysfunction (creatinine should be less than or equal to 2.5 mg/dL in men and less than or equal to 2.0 mg/dL in women) or hyperkalemia (potassium should be less than or equal to 5.0 mEq/L) who are already receiving therapeutic doses of an ACE inhibitor, have a LVEF less than or equal to 0.40, and have either symptomatic heart failure or diabetes."