Clopidogrel News and Research

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Clopidogrel is an oral antiplatelet agent (thienopyridine class) to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.

World's largest study on acute coronary syndromes

A Canadian-led study involving researchers from 41 countries has demonstrated in the world's largest study of acute coronary syndromes (ACS) that a new anti-thrombotic therapy is safer and as effective as the traditional therapy used in preventing heart attacks, death and ischemia in people with serious heart conditions.

5 Sep 2005

Medication before angiograph significantly reduces risk of heart attack

According to new research if patients are given the a drug which reduces platelet activity in the blood risk of heart attack and cardiovascular death before and after angioplasty is reduced.

4 Sep 2005

Latest findings on aspirin resistance

Treatment failures occur with any drug and aspirin is no exception. Evidence is growing that some people will not respond to the anti-coagulant action of aspirin and the drug will not protect against cardiovascular events despite its regular intake.

9 Aug 2005

New drug combo helps prevent strokes

A British research team at St. George's Hospital Medical School in London, have found that the addition of the anti-clotting drug Plavix to daily doses of aspirin helps prevent the risk of later strokes better than using aspirin alone.

25 Apr 2005

Blacks less likely to get expensive, newer heart treatments

Blacks who suffer the most common type of cardiac ischemia – non-ST-elevation acute coronary syndrome – are less likely than whites to receive expensive or newer evidence-based treatments, according to a report in a special disparities themed issue of Circulation: Journal of the American Heart Association.

15 Mar 2005

Emergency clopidogrel could save thousands of lives worldwide

Adding the anti-platelet drug clopidogrel to aspirin for the emergency treatment of heart attacks could save thousands of lives a year worldwide and prevent thousands of repeat heart attacks and strokes, according to new research presented at the American College of Cardiology annual conference.

9 Mar 2005

Use of cilostazol, clopidogrel and aspirin results in a significant reduction of thrombotic complications in the prevention of heart attacks

Three drugs, each of which works in a different way, are used in anti-platelet therapy to help prevent restenosis (the reclogging of blood vessels after they have been cleared with percutaneous coronary intervention or PCI) or thrombosis (obstruction of an artery or vein by a blood clot).

7 Mar 2005

Studies find Aspirin resistance in up to 27% of Aspirin users

While aspirin remains a crucial and cost-effective therapy for the prevention and management of cardiovascular diseases, research suggests that a significant percentage of the 25 million Americans on a chronic aspirin regimen are "aspirin resistant," or do not achieve sufficient antiplatelet effects from aspirin.

7 Mar 2005

St. John's wort increases effectiveness of Plavix

The widely used herbal remedy St. John's wort appears to amplify the action of the popular blood-thinning drug clopidogrel, sold as Plavix, a small new clinical study finds.

6 Mar 2005

Heart patients with gastrointestinal complications should use low doses of aspirin combined with drugs that treat stomach ulcers

Physicians are challenged in treating heart patients who may be at high-risk for gastrointestinal bleeding from aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Factors that place patients at high-risk include a history of ulcers or gastrointestinal complications such as bleeding, increased age and congestive heart failure.

20 Jan 2005

Clopidogrel (Plavix®) responses appear normal in largest data set

Although individual patients respond differently to treatment with the anti-platelet medication clopidogrel (brand name Plavix®), those variations appear normal and may not indicate important differences in the effectiveness of treatment, according to a new study (PDF file) in the Jan. 18, 2005 issue of the Journal of the American College of Cardiology.

19 Jan 2005

Angioplasty may replace bypass for more patients who are also receiving a new heart valve

The death rate during combination surgery to bypass clogged coronary arteries and simultaneously replace a heart valve in very sick patients can be as high as one in five, but a review of records of very sick patients who underwent balloon angioplasty, followed by heart valve replacement surgery, found only one death among 26 patients.

4 Jan 2005