While aspirin remains a crucial and cost-effective therapy for the prevention and management of cardiovascular diseases, research suggests that a significant percentage of the 25 million Americans on a chronic aspirin regimen are "aspirin resistant," or do not achieve sufficient antiplatelet effects from aspirin. The VerifyNow Aspirin Test (Ultegra) is emerging as an important tool to aid clinicians in quantifying this risk and taking appropriate action.
Previous studies have shown that aspirin resistance is associated with triple the risk of heart attack, stroke and death. Once patients are tested and identified as aspirin resistant, physicians may opt for an alternative approach to therapy, which may include increasing the dosage of aspirin or placing the patient on another antiplatelet medication.
New studies reported at the 2005 Annual Scientific Session of the American College of Cardiology (ACC) confirm that up to 27 percent of aspirin users with coronary artery disease (CAD) are resistant to aspirin's antiplatelet effects, and further indicates that women, the elderly and those taking lower doses of aspirin most likely to be aspirin resistant. These and other characteristics are now said to be "predictors" of aspirin resistance. Additionally, research indicates that resistance to aspirin and clopidogrel (or Plavix) may occur together, as studied in patients undergoing coronary procedures, such as percutaneous coronary intervention (PCI).
These are among the numerous findings released at the ACC, emphasizing the scope of the issue and the role of testing for aspirin resistance, adding to the growing body of research and interest in this topic from the cardiology community.
Up to 27 percent of patients with well-documented CAD on an aspirin regimen for at least four weeks were found to be resistant to aspirin's antiplatelet effects, determined by the VerifyNow Aspirin test, according to research reported by Dr. W.H. Chen and colleagues at the University of Hong Kong. The study of 468 patients provided insight into the nature of aspirin resistance by identifying patient characteristics significantly associated with increased risk for the condition. Women, the elderly, those with renal insufficiency, low hemoglobin levels and those taking low-dose aspirin were found to have the highest likelihood of being aspirin resistant.
In particular, the authors identified that dosage of aspirin directly correlates with the prevalence of aspirin resistance. The highest prevalence of aspirin resistance was associated with doses of less than 100 mg (30.2%), was less prevalent in higher aspirin doses of 150 mg (16.7%), and non-existent with 300 mg (0 %). Separately, a meta-analysis of 200,000 people also presented at the ACC meeting showed that risk of bleeding increases with increasing doses of aspirin (especially 325 mg). In combination, these two studies suggest that a balance between safety and effectiveness needs to be achieved so that the lowest, effective dose is prescribed and patients are confirmed responsive to their aspirin regimen.