Cross Linking News and Research

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Scientists develop genome-wide platform to study how specialized proteins regulate RNA in living, intact cells

DNA, it has turned out, isn't all it was cracked up to be. In recent years we learned that the molecule of life, the discovery of the 20th century, did not -- could not -- by itself explain the huge differences in complexity between a human and a worm.

2 Nov 2008

New antibiotics to fight MRSA

A new paper by Shahriar Mobashery, Navari Family Professor in Life Sciences at the University of Notre Dame, and researchers in his lab provides important insights into promising new antibiotics aimed at combating MRSA.

28 Jul 2008

Scientists determine molecular structures of bacterial AlkB protein and its corresponding human protein, ABH2

A team of University of Chicago scientists has shown how two proteins locate and repair damaged genetic material inside cells.

23 Apr 2008

Protein-cross-linked polymeric materials through site-selective bioconjugation

Researchers at the University of California, Berkeley (USA) have now developed a new strategy for the formation of hybrid materials from synthetic polymers and proteins. They have thus been able to fuse the specific biological functions of proteins with the advantageous bulk and processing properties of plastics.

18 Apr 2008

Researchers create modular, multi-functional drug delivery system

There are two aspects to creating an effective drug: finding a chemical compound that has the desired biological effect and minimal side-effects and then delivering it to the right place in the body for it to do its job.

8 Oct 2007

Radical research results on the oxidation of vitamin E

Recent research results have challenged conventional understanding of the oxidation of the "radical scavenger", vitamin E. Cutting-edge analysis methods have revealed that the intermediates commonly believed to be involved in the process do not occur.

24 Sep 2007

Researchers discover how antibiotic linezolid inhibits bacterial growth

Researchers at the University of Illinois at Chicago, in collaboration with research teams from Pharmacia & Upjohn and Pfizer, have discovered precisely how the antibiotic linezolid inhibits bacterial growth.

11 May 2007

Relationship found between DNA nanomechanics and damage

It has long been known that UV light can damage DNA, reducing its ability to replicate and interact with proteins, and often resulting in the development of skin cancers.

25 Apr 2007

Anika Therapeutics receives European stamp of approval for cosmetic dermatology product

Anika Therapeutics has announced that it has received CE Mark certification for the commercial sale of its cosmetic dermatology product, ELEVESS, in the European Union.

15 Apr 2007

Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles

Many types of nanoparticles can cross the cell membrane and deliver their therapeutic payload into tumor cells.

3 Jul 2006

Gardenia fruit compound helps treat the symptoms of type 2 diabetes

A Gardenia fruit extract traditionally used in Chinese medicine to treat the symptoms of type 2 diabetes does indeed contain a chemical that reverses some of the pancreatic dysfunctions that underlie the disease, researchers report in Cell Metabolism.

6 Jun 2006

Alagebrium may prevent arterial aging in patients with systolic hypertension

A compound called alagebrium, which is very similar to another used in anti-wrinkle creams, may be useful in reducing the deleterious effects of arterial aging in the majority of elderly Americans with systolic hypertension, a new study from researchers at Johns Hopkins shows.

5 Dec 2005

Protein called CPSF73 performs a necessary step in the production of human chromosomes

The study found that a protein called CPSF73 acts like scissors to cut strands of histone messenger RNA (mRNA) in the cell nucleus. This cutting action produces the mRNA needed to create histone proteins that combine with DNA to form chromosomes.

12 Oct 2005

Virginia Tech engineer investigates enzyme link to Huntington's, Parkinson's, and Alzheimer diseases

Several neurologically based afflictions, such as Huntington's, Parkinson's, and Alzheimer diseases, have been correlated to a higher than normal presence of a specific type of enzymes, called transglutaminases (TGase) in the human body.

30 Aug 2005

Green alga closes wounds by means of enzymatic activation of a cross-linking protein

A small wound is painful, but is normally not a problem. Like all multicellular organisms, our bodies form new tissue around the damaged cells. Single-celled organisms cannot do this. In order to survive an injury, they have to quickly repair the cell itself. Large single-celled organisms, such as the green alga Caulerpa taxifolia, which can be several meters long, are especially at risk for injuries.

22 Mar 2005

Novel approach to bioengineer artificial skin for burn victims

Each year more than 45,000 Americans suffer burns serious enough to require a hospital stay, according to the American Burn Association. While the traditional therapy of using skin grafts to cover burn sites has improved, a number of problems including scarring, infection and poor adhesion remain.

4 Jan 2005

40-year tale of investigation and innovation into the challenge of hip implant failure

A remarkable story of how a new disease was inadvertently caused by successful medical treatment, ultimately understood, and eventually defeated by scientific innovation is being told a major player in the process.

22 Dec 2004

Research looks at the relationship between fetal health during pregnancy and later development of the brain

A new Canada Research Chair (CRC) at The University of Western Ontario is studying the relationship between fetal health during pregnancy and later development of the brain.

24 Nov 2004

Funding improves the quality of the fish we eat

The quality of the fish that ends up in the shops, and eventually on our dining tables, is set to improve following a three and a half year research project into the monitoring techniques available to the fish processing industry.

15 Jul 2004

Important milestone for any cancer therapy that will be useful for treating patients

Mayo Clinic researchers have manipulated a human antibody to induce an anti-tumor response in living mice that consistently curbs - and often cures - malignant melanoma, one of the most lethal forms of skin cancer and the most common cancer of young adults.