Cytomegalovirus News and Research

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Cytomegalovirus (CMV) is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella-zoster virus (which causes chickenpox), and Epstein-Barr virus (which causes infectious mononucleosis). Infection with CMV is a major cause of disease and death in immunocompromised patients, including organ transplant recipients, patients undergoing hemodialysis, patients with cancer, patients receiving immunosuppressive drugs, and HIV-infected patients. While drugs are available for treatment of these conditions, the primary drug choices carry significant side effects and warnings. Currently, there are no anti-CMV drugs indicated for treatment of primary CMV infection during pregnancy resulting in infections that can have catastrophic consequences to the newborn. Maternal-fetal transfer of CMV infection results in a fetal death rate of 12% and most survivors have permanent debilitating disorders, including mental retardation, vision loss, and sensorineural deafness.

Discovery of a potential new target for new MPOX or broad pox vaccines

In a recent study posted to the medRxiv* preprint server, researchers in the United Kingdom developed a pooled enzyme-linked immunosorbent (ELISA) assay using mpox (MPX) virus (MPXV) antigens and vaccinia virus (VACV) antigens. They also assessed humoral responses to and identification of antigens of MPXV IIa clade and IIb clade, in comparison to recipients of smallpox vaccines (ACAM2000 and IMVANEX).

12 Jan 2023

Investigational T-cell therapy shows antiviral efficacy and safety in cancer patients treated with stem cell transplant

Posoleucel, an investigational allogeneic off-the-shelf T-cell therapy that simultaneously targets six different viruses, demonstrated promising antiviral efficacy and safety in a phase II study of patients who had undergone stem cell transplantation to treat their cancer or other blood diseases.

11 Jan 2023

What is the association between acute lymphoblastic leukemia and congenital cytomegalovirus infection?

Researchers evaluated the relationship between congenital cytomegalovirus (cCMV) infection and acute lymphoblastic leukemia (ALL).

11 Jan 2023

Meta-analysis reviews the incidence of new-onset diabetes in COVID-19 survivors

Researchers estimated the incidence of new-onset diabetes in survivors of coronavirus disease 2019 (COVID-19) employing random-effects meta-analyses using the generic inverse variance method.

30 Nov 2022

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Researchers investigate the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of COVID-19.

28 Nov 2022

Could mRNA vaccines triumph over other viral infections in humans and domestic animals?

Researchers review potential areas for mRNA vaccine development against pathogenic viruses other than SARS-CoV-2.

28 Nov 2022

Rutgers scientists develop new approach to effectively shut down viral infections

Rutgers scientists have developed a new approach to stopping viral infections: a so-called live-attenuated, replication-defective DNA virus vaccine that uses a compound known as centanamycin to generate an altered virus for vaccine development.

20 Nov 2022

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

In a recent study posted to the bioRxiv* preprint server, researchers evaluated responses of natural killer (NK) lymphocytes to VACV (vaccinia virus) infections in vivo.

16 Nov 2022

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Researchers investigated the early T cell responses during SARS-CoV-2 infections to understand the mechanisms of rapid clonal expansion that characterize the T cell responses to acute infections and vaccinations.

14 Nov 2022

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Researchers investigated the change in the stability, antigenicity, and protein expression of the SARS-CoV-2 spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein.

14 Nov 2022

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

A new study aimed to analyze the molecular interactions between the hCypA protein and the SARS-CoV-2 variants to determine the impact of variants on the blocking and binding potential of the hCypA–S protein complex with the ACE2 receptor.

2 Nov 2022

Myocarditis may be attributable to monkeypox infection

A new study published in Emerging Infectious Diseases found that myocardial infiltration could cause myocarditis during monkeypox virus infection.

5 Oct 2022

Study reveals immune characteristics of long-COVID

Researchers perform antibody profiling against SARS-CoV-2, several endemic pathogens, as well as vaccine antigens among rheumatic disease patients.

2 Oct 2022

What is the association between air ventilation and pathogen transmission?

Researchers assessed the association between indoor air respiratory pathogens and natural ventilation, carbon dioxide (CO2) levels, and air filtration.

27 Sep 2022

SARS-CoV-2 RNA and antibody detection in infected mothers’ breast milk

In a recent study published in the Journal of Medical Virology, Italian researchers investigated the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) and antibodies (Abs) in the milk of breastfeeding mothers with SARS-CoV-2 infections.

14 Sep 2022

Infections during pregnancy may not pose great risk to the baby's brain, study shows

Infections in pregnant women have been linked to an increased risk of neurodevelopmental conditions, such as autism, in the child later in life. But it does not seem to be the infections themselves that cause autism, researchers from Karolinska Institutet in Sweden show in a study published in The Lancet Psychiatry.

8 Sep 2022

Cytomegalovirus News and Research

Further Reading

Discovery of a potential new target for new MPOX or broad pox vaccines

Investigational T-cell therapy shows antiviral efficacy and safety in cancer patients treated with stem cell transplant

What is the association between acute lymphoblastic leukemia and congenital cytomegalovirus infection?

Meta-analysis reviews the incidence of new-onset diabetes in COVID-19 survivors

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Could mRNA vaccines triumph over other viral infections in humans and domestic animals?

Rutgers scientists develop new approach to effectively shut down viral infections

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

Myocarditis may be attributable to monkeypox infection

Study reveals immune characteristics of long-COVID

What is the association between air ventilation and pathogen transmission?

SARS-CoV-2 RNA and antibody detection in infected mothers’ breast milk

Infections during pregnancy may not pose great risk to the baby's brain, study shows

Study: Number of babies born with cytomegalovirus decreased during the COVID-19 pandemic

The currently available evidence on viral-induced parkinsonism

New study provides comparison of replicating and non-replicating vaccines against SARS-CoV-2

Doctors discover genetic and viral causes of adenoid hypertrophy in kids

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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