DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

Combination of genetic and environmental factors increases the risk of cleft lip

A cleft lip or palate arises from the combined effects of genes and inflammatory risk factors experienced during pregnancy, such as smoking or infections, finds a new study led by UCL researchers.

24 May 2023

Researchers develop a computational approach to predict diabetic kidney disease

Researchers from Sanford Burnham Prebys and the Chinese University of Hong Kong have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease, a frequent and dangerous complication of diabetes.

15 May 2023

New approaches to promote healthspan from an epigenetic perspective

A new review paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "How can we modulate aging through nutrition and physical exercise? An epigenetic approach."

10 May 2023

Silenced p16 gene can drive colorectal cancer progression

Colorectal cancer is the fourth most common and second deadliest cancer. How colorectal cancer develops is not well understood, but a team led by researchers at Baylor College of Medicine reports in the Journal of Experimental & Clinical Cancer Research that silencing the gene p16, even though the DNA itself does not change, can drive colorectal cancer progression in animal models.

10 May 2023

Does stress increase biological age?

Researchers evaluated stress-induced biological age (BA) changes among mice and humans.

4 May 2023

Environmental exposures during pregnancy can affect obesity risk differently in girls and boys, according to a study

A study published in the journal BMC Medicine describes that the risk of obesity and neurodevelopmental delay can vary between boys and girls concerning certain types of prenatal exposures. The study identifies a combination of four exposure levels that protect girls from developing these complications.

13 Apr 2023

Analyzing DNA changes in the blood can improve prediction of type 2 diabetes risk

Analyzing changes to DNA in the blood can improve the ability to predict a person's risk of developing type 2 diabetes within a decade.

6 Apr 2023

Early life adversity linked to accelerated neurobiological aging, raising vulnerability to depression and Alzheimer's

scientists investigate the neurocognitive correlates of genetic vulnerability to major depressive disorder and Alzheimer's disease.

30 Mar 2023

Ask the Expert: 7 Questions about Colorectal Cancer & Non-invasive Fecal DNA Testing

In this interview, NewsMedical speaks with Dr. Yuying Wang, R&D Director (Oncology), from BGI Genomics, about colorectal cancer and the development and application of COLOTECT® 1.0, a non-invasive fecal DNA test for the detection of colorectal cancer and pre-cancerous lesions.

From BGI Genomics 27 Mar 2023

Age-induced methylation changes in the sperm epigenome contribute to offspring's medical problems

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Age-related methylation changes in the human sperm epigenome."

21 Mar 2023

Investigating how gut microbiota affect neuroplasticity and neurodevelopment

In a recent study published in the journal Neuropharmacology, researchers in Pisa, Italy, explored how gut microbiota can influence neuroplasticity.

20 Mar 2023

Machine learning applications for the diagnosis, treatment and prognosis of cancer

Researchers review the application of machine learning in improving cancer diagnosis, treatment, and prognosis.

19 Mar 2023

How maternal obesity and gestational diabetes can impact DNA methylation in infants

A study published in the journal Cardiovascular Diabetology describes that maternal obesity and gestational diabetes can induce epigenetic remodeling in infants, potentially impacting metabolic and developmental pathways.

6 Mar 2023

Maternal obesity associated with adverse metabolic health outcomes in childhood

Research by the University of the Basque Country indicates that changes caused by maternal obesity could lead to adverse health outcomes in childhood.

3 Mar 2023

Epigenetic changes in the regulation of key stress gene detected in kids with abusive injuries

Epigenetic changes in the regulation of a key gene in the body's stress response system were detected in babies and young children with abusive injuries, as opposed to accidental, according to a pilot study published in the journal Pediatric Research.

2 Mar 2023

Tecan and Oxford Nanopore build alliance to create automated, seamless and fully compatible nanopore sequencing library preparation for any-length fragments of native DNA/RNA

The Tecan Group and Oxford Nanopore Technologies plc (Oxford Nanopore) today announce their collaboration to drive easier high-throughput nanopore library preparation in an automated, hands-free fashion.

From Tecan 27 Feb 2023

Innovative methodology to detect viral RNA

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia, the Institute of Microelectronics of Barcelona and the Aragon Nanoscience and Materials Institute of Aragon —a joint institute of the CSIC and the University of Zaragoza— have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

27 Feb 2023

The relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality

Researchers assessed the association between deoxyribonucleic acid methylation (DNAm)-based clocks or aging measures and demographic and serological parameters in estimating health-associated outcomes, including deaths.

24 Feb 2023

Study may elucidate metformin's potential role in longevity through DNA methylation

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 3, entitled, "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity."

22 Feb 2023

Mount Sinai study sheds new light on the role of DNA methylation in Alzheimer's disease

Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).