DNA Replication News and Research

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.

Repressing a protein that facilitates DNA repair to potentiate chemotherapy

Chemotherapy kills tumor cells by causing damage to them. One of the most effective ways of causing damage is to prevent the two DNA strands from separating so that the cellular machinery cannot read the instructions written in the genes.

15 Jun 2021

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients

Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer.

19 Apr 2021

Japanese–European scientists detect novel genetic mitochondrial disorder

The list of known genetic mitochondrial disorders is ever-growing, and ongoing research continues to identify new disorders in this category.

15 Apr 2021

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication.

6 Apr 2021

Targeting microRNAs makes cancer stem cells more susceptible to chemotherapies

Researchers in Italy have identified a pair of microRNA molecules that help maintain a population of cancerous stem cells that drive the growth of breast cancers and initiate tumor relapse after treatment.

3 Apr 2021

UCLA researchers receive NIH grants to identify new ways to treat pancreatic cancer

A team of researchers from the UCLA Jonsson Comprehensive Cancer Center has been awarded two research grants totaling $6 million from the National Institutes of Health to identify new ways to treat pancreatic cancer.

25 Mar 2021

Underrepresentation in genomic databases may affect therapy selection for minority patients

Low representation of minority groups in public genomic databases may affect therapy selection for Black patients with cancer, according to new Mayo Clinic research published in npj Precision Oncology.

19 Mar 2021

Critical mechanism allows deadly bacteria to gain resistance to antibiotics

Researchers have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics.

9 Mar 2021

Study demonstrates the impact of 'reverse antibiotic' on gram-negative bacteria

Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal Antimicrobial Agents and Chemotherapy.

5 Mar 2021

Study: Interbacterial toxins may contribute to bacterial genetic diversity

A toxin produced by bacteria as a defence mechanism causes mutations in target bacteria that could help them survive, according to a study published today in eLife.

23 Feb 2021

Study: Quantum mechanics plays a role in biological processes and causes mutations in DNA

Quantum biology is an emerging field of science, established in the 1920s, which looks at whether the subatomic world of quantum mechanics plays a role in living cells.

22 Feb 2021

Scientists examine DNA repair pathways and their impact on cancer evolution

DNA repair pathways exist to correct molecular damage caused by internal and external factors. However, any damage to these pathways can result in the creation of tumors and specific types of cancers.

17 Feb 2021

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

A new study by researchers at the University of Manchester, UK, reports on the compounds of interest that were identified as having potential for the treatment of COVID-19, from a library of almost 2,000 compounds from the APExBIO DiscoveryProbe library.

3 Feb 2021

Wistar researchers discover new enzymatic function of the Epstein-Barr Virus protein

Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer.

27 Jan 2021

New study unravels complete sequence of DNA repair mechanism

Every living organism has DNA, and every living organism engages in DNA replication, the process by which DNA makes an exact copy of itself during cell division. While it's a tried-and-true process, problems can arise.

25 Jan 2021

Researchers develop a technique to modify biological polymers with protein-based biochemical messages

Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own.

18 Jan 2021

DNA Replication News and Research

Further Reading

Repressing a protein that facilitates DNA repair to potentiate chemotherapy

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients

Japanese–European scientists detect novel genetic mitochondrial disorder

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Targeting microRNAs makes cancer stem cells more susceptible to chemotherapies

UCLA researchers receive NIH grants to identify new ways to treat pancreatic cancer

Underrepresentation in genomic databases may affect therapy selection for minority patients

Critical mechanism allows deadly bacteria to gain resistance to antibiotics

Study demonstrates the impact of 'reverse antibiotic' on gram-negative bacteria

Study: Interbacterial toxins may contribute to bacterial genetic diversity

Study: Quantum mechanics plays a role in biological processes and causes mutations in DNA

Scientists examine DNA repair pathways and their impact on cancer evolution

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

Wistar researchers discover new enzymatic function of the Epstein-Barr Virus protein

New study unravels complete sequence of DNA repair mechanism

Researchers develop a technique to modify biological polymers with protein-based biochemical messages

Study highlights the far-reaching effects of mutagenic compounds on human health

Discovery of protein function could be important for future chemotherapy treatment

Hybrid approach reveals details about genes involved in Meier-Gorlin syndrome

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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