Diastolic Dysfunction News and Research

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Diastolic dysfunction refers to an abnormality in the heart's (''i.e.'', left ventricle's) filling during diastole. Diastole is that phase of the cardiac cycle when the heart (i.e. ventricle) is not contracting but is actually relaxed and filling with blood that is being returned to it, either from the body (into right ventricle) or from the lungs (into left ventricle).

Diabetes is an independent risk factor for development of heart failure, study shows

Heart problems are a common development for people with diabetes. In fact, about 33% of people in the U.S. admitted to the hospital for heart failure also have diabetes. Heart failure may be the result of a co-condition, such as hypertension or coronary heart disease, but not always.

2 Jan 2020

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

25 Sep 2019

CAR T-cell therapy may be viable treatment option for heart disease

CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients' own cells to treat certain types of cancers, may be a viable treatment option for another life-threatening condition: heart disease.

12 Sep 2019

Researchers find new target for disease of the heart's smallest blood vessels

When we race walk, for example, part of our healthy heart muscle may want a little more blood and oxygen, so our tiniest blood vessels send a message upstream to the larger vessels to send more.

12 Aug 2019

Vortex flow closely linked to pressure differences in ventricles of the heart

Japanese scientists at Tokyo University of Agriculture and Technology, Teikyo University of Science, and Juntendo University have found -- in animal studies -- a close relationship between vortex flow and pressure differences in the ventricles, or lower chambers, of the heart.

24 Jun 2019

Higher coronary artery calcium levels in middle-age linked to increased risk for future heart problems

Higher coronary artery calcium levels in middle-age were associated with structural heart abnormalities linked to future heart failure, particularly among blacks, according to new research in Circulation: Cardiovascular Imaging, an American Heart Association journal.

16 Jun 2019

UMN Medical School research uncovers how to treat diastolic heart failure

Research out of University Minnesota Medical School and published in the Journal of Clinical Investigation Insight uncovers what causes diastolic heart failure and how it can be treated.

10 Jan 2019

Fish-rich and vegetarian diet may reduce hypertension-related heart disease symptoms

Elevated levels of trimethylamine N-oxide--a compound linked with the consumption of fish, seafood and a primarily vegetarian diet--may reduce hypertension-related heart disease symptoms.

7 Nov 2018

Study improves understanding of preeclampsia heart damage in pregnancy

Johns Hopkins researchers say a heart imaging study of scores of pregnant women with the most severe and dangerous form of a blood pressure disorder has added to evidence that the condition -; known as preeclampsia -; mainly damages the heart's ability to relax between contractions, making the organ overworked and poor at pumping blood.

6 Aug 2018

MGH researchers discover that macrophages contribute to untreatable type of heart failure

A team of Massachusetts General Hospital investigators has discovered, for the first time, that the immune cells called macrophages contribute to a type of heart failure for which there currently is no effective treatment.

14 Feb 2018

Researchers test effectiveness of investigational drug in treating diastolic dysfunction of the heart

Researchers at the University of Colorado School of Medicine have identified a potential treatment target for patients with a common type of heart failure.

8 Feb 2018

Reducing mitochondrial protein in cardiac muscle cells initiates heart failure

Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure, a finding that could provide insight for new treatments for cardiovascular diseases, a study led by Georgia State University has shown.

6 Dec 2017

New MyoVista hsECG device launched in the European Union for early detection of heart disease

HeartSciences today announced the European launch of MyoVista high sensitivity electrocardiograph (hsECG) Testing Device, developed in response to the global unmet need for effective, low-cost, front-line screening of cardiac disease in both symptomatic and asymptomatic patients.

18 Aug 2017

Diabetes medication can protect against cardiac stiffening in obese female mice

Overconsumption of a Western diet high in fats and refined sugars has contributed to a global increase in obesity and Type 2 diabetes.

6 Jun 2017

Study identifies early signs of heart changes for women with preeclampsia

In a study to be presented Friday, Jan. 27, in the oral concurrent session at 1:15 p.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting™, researchers with the Maternal and Child Health Research Center and the Department of Cardiology at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, will present findings of a study titled Cardiac Dysfunction in Preeclampsia is Present at Diagnosis and Persists Postpartum.

23 Jan 2017

New experimental model may predict eventual cardiac phenotype in pediatric patients

An experimental model uses genetics-guided biomechanics and patient-derived stem cells to predict what type of inherited heart defect a child will develop, according to authors of a new study in the journal Cell.

21 May 2016

Studies show AHA's Life's Simple 7 and Diabetes Shared Care Program reduce lifetime risk of heart failure

One in four middle-aged adults who survive to age 85 will develop heart failure, according to current estimates.

15 Sep 2015

FDA, EMA accept filing applications for Boehringer Ingelheim's afatinib to treat patients with advanced SCC of the lung

Boehringer Ingelheim today announced that both the U.S. Food and Drug Administration and the European Medicines Agency have accepted filing applications for afatinib for the treatment of patients with advanced squamous cell carcinoma (SCC) of the lung progressing after treatment with first-line chemotherapy.

26 Aug 2015

Boehringer announces LUX-Lung 8 data that compares efficacy of afatinib, erlotinib in patients with advanced SCC

Boehringer Ingelheim today announced overall survival (OS) results from the LUX-Lung 8 trial (NCT01523587) that directly compared the efficacy and safety of two EGFR-directed treatments, afatinib and erlotinib, in patients with advanced squamous cell carcinoma (SCC) of the lung, progressing after treatment with first-line chemotherapy. Treatment with afatinib significantly reduced the risk of death by 19%, extending the survival of patients to a median of 7.9 months compared to 6.8 months on erlotinib.

1 Jun 2015

Mediterranean diet improves cardiovascular performance in patients with erectile dysfunction

The Mediterranean diet is linked to improved cardiovascular performance in patients with erectile dysfunction, according to research presented at EuroEcho-Imaging 2014 by Dr Athanasios Angelis from Greece. Patients with erectile dysfunction who had poor adherence to the Mediterranean diet had more vascular and cardiac damage.

3 Dec 2014