Dopamine News and Research

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Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.

UTHealth to study BMS-820836 in Phase II trial for major depressive disorder

A new medication to treat major depressive disorder in patients who have not responded to other antidepressants is being studied in a Phase II clinical trial by researchers at The University of Texas Health Science Center at Houston.

2 Sep 2011

New guidelines for the treatment of acromegaly, a serious growth hormone disorder

It’s said a lot can happen in seven days. In seven years, a lot has happened in the understanding of acromegaly, a debilitating condition that causes a patient to have too much growth hormone. It’s seven years since the American Association of Clinical Endocrinologists last produced guidelines for the diagnosis and treatment of acromegaly. Their 2004 guidelines were just 13 pages long. Their latest, the 2011 guidelines, have grown – to 44 pages.

31 Aug 2011

DaTscan allows doctors to differentiate Parkinson's from other movement disorders

Thanks to a new diagnostic imaging technique, physicians now have an objective test to evaluate patients for parkinsonian syndromes, such as Parkinson's disease. Northwestern Memorial Hospital is among the first institutions in the country to offer DaTscan-, the only FDA-approved imaging agent for assessment of movement disorders.

26 Aug 2011

Researchers discover how antipsychotic drugs manage symptoms of schizophrenia

The classic symptoms of schizophrenia - paranoia, hallucinations, the inability to function socially-can be managed with antipsychotic drugs. But exactly how these drugs work has long been a mystery.

25 Aug 2011

Parkinson’s disease breakthrough with stem cell research

A new stem cell study has raised hopes for therapy in Parkinson's disease. Researchers said they have, for the first time, generated stem cells from one of the most rapidly-progressing forms of the disease. They said the development will boost research into the condition because it will allow scientists to model the disease in laboratories and help them shed light on why certain nerve cells die. The research was led by the University of Edinburgh in collaboration with University College London (UCL).

24 Aug 2011

Health Canada accepts Sunovion Pharmaceuticals Canada's lurasidone NDS for review

Sunovion Pharmaceuticals Canada Inc., formerly Sepracor Pharmaceuticals, Inc., today announced that the New Drug Submission (NDS) for Lurasidone HCl, for the treatment of adult patients with schizophrenia has been accepted for review by Health Canada. The NDS was submitted to Health Canada in June 2011 and will receive a standard review.

24 Aug 2011

Scientists identify molecular pathway that plays a key role in stress-related DNA damage

Working closely with a team of researchers from Duke University, scientists from the Florida campus of The Scripps Research Institute have helped identify a molecular pathway that plays a key role in stress-related damage to the genome, the entirety of an organism's hereditary information.

23 Aug 2011

Risk of Parkinson's disease increases with traumatic brain injury and exposure to pesticide paraquat

Traumatic brain injury has entered the public's consciousness as the silent, signature wound brought back by many of our military warriors from Iraq and Afghanistan. But such injuries don't only happen in warfare, they happen to civilians too. Think car crashes, a slip and fall, two football players colliding helmet to helmet.

22 Aug 2011

More kids being diagnosed with ADHD

A new study revealed that number of children diagnosed with Attention Deficit Hyperactivity disorder or ADHD has risen sharply over the last decade.

18 Aug 2011

Scientists artificially grow brain cells from Parkinson's patients to find treatment

The UK's population is ageing and with it comes an increased risk of developing age-related diseases such as Parkinson's. About 70% of dopamine producing brain cells will have been lost by the time a sufferer visits the doctor, with symptoms that include difficulties with movement and a resting tremor. A progressive neurodegenerative disease, Parkinson's affects about 120,000 people in the UK.

18 Aug 2011

Researchers to unravel how brain makes everyday prognostications

Every day we make thousands of tiny predictions - when the bus will arrive, who is knocking on the door, whether the dropped glass will break. Now, in one of the first studies of its kind, researchers at Washington University in St. Louis are beginning to unravel the process by which the brain makes these everyday prognostications.

18 Aug 2011

NIH study in mice shows potential new target for treatment of ADHD

A study using mice provides insight into how a specific receptor subtype in the brain could play a role in increasing a person's risk for attention-deficit hyperactivity disorder.

17 Aug 2011

Biochemist develops polymer material to convert precursor cells into functional neurones

Nervous system diseases are especially difficult to treat, as it is not easy to replace the parts of the neural puzzle which are damaged. The key is in developing functional neurons from in vitro-treated, cells but for this it is essential that the support on which these cells are based simulate the characteristics of the nervous system.

16 Aug 2011

Mice with enzyme deficiency are unable to properly assess threat

Do you run when you should stay? Are you afraid of all the wrong things? An enzyme deficiency might be to blame, reveals new research in mice by scientists at the University of Southern California.

12 Aug 2011

Scientists identify new therapeutic target for ADHD, other neuropsychiatric disorders

A biochemical pathway long associated with diarrhea and intestinal function may provide a new therapeutic target for treating ADHD other neuropsychiatric disorders, according to a team of scientists from China and the United States reporting Aug. 11 in Science.

12 Aug 2011

Roadmap to overcome obstacles for using induced pluripotent stem cells

The possibility of developing stem cells from a patient's own skin and using them to treat conditions as diverse as Parkinson's disease, Alzheimer's disease and cancer has generated tremendous excitement in the stem cell research community in recent years. Such therapies would avoid the controversial need for using stem cells derived from human embryos, and in theory, also bypass immunological problems inherent in using cells from one person to treat another.

5 Aug 2011

Stress management can improve chronic skin conditions

As anyone with a chronic, inflammatory skin condition, such as psoriasis, rosacea or acne, knows, dealing with unpredictable flares can cause considerable stress and have a negative impact on a person's overall well-being.

4 Aug 2011

Nicotine protects against Parkinson's disease

If you've ever wondered if smoking offered society any benefit, a new research report published in The FASEB Journal offers a surprising answer. Nicotine protects us from Parkinson's disease, and the discovery of how nicotine does this may lead to entirely new types of treatments for the disease.

2 Aug 2011

New neurobehavioral model for obesity counseling

Current approaches to dietary counseling for obesity are heavily rooted in the notion of personal choice and will power - the ability to choose healthy foods and portion sizes consistent with weight loss while foregoing sweets and comfort foods.

1 Aug 2011

Scientists examine relationship between REM sleep behaviour disorders, Parkinson's disease

Patients suffering REM sleep behaviour disorders dream nightmares in which they are attacked and pursued, with the particularity that they express them by screaming, crying, punching and kicking while sleeping.

30 Jul 2011

Dopamine News and Research

Further Reading

UTHealth to study BMS-820836 in Phase II trial for major depressive disorder

New guidelines for the treatment of acromegaly, a serious growth hormone disorder

DaTscan allows doctors to differentiate Parkinson's from other movement disorders

Researchers discover how antipsychotic drugs manage symptoms of schizophrenia

Parkinson’s disease breakthrough with stem cell research

Health Canada accepts Sunovion Pharmaceuticals Canada's lurasidone NDS for review

Scientists identify molecular pathway that plays a key role in stress-related DNA damage

Risk of Parkinson's disease increases with traumatic brain injury and exposure to pesticide paraquat

More kids being diagnosed with ADHD

Scientists artificially grow brain cells from Parkinson's patients to find treatment

Researchers to unravel how brain makes everyday prognostications

NIH study in mice shows potential new target for treatment of ADHD

Biochemist develops polymer material to convert precursor cells into functional neurones

Mice with enzyme deficiency are unable to properly assess threat

Scientists identify new therapeutic target for ADHD, other neuropsychiatric disorders

Roadmap to overcome obstacles for using induced pluripotent stem cells

Stress management can improve chronic skin conditions

Nicotine protects against Parkinson's disease

New neurobehavioral model for obesity counseling

Scientists examine relationship between REM sleep behaviour disorders, Parkinson's disease

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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