Epigenetics News and Research

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Epigenetics is the study of chemical reactions that influence gene expression, through activation or deactivation of genes at specific times and locations.

Epigenetic changes from stress exposure can be passed from traumatized parent to offspring

The children of traumatized people have long been known to be at increased risk for posttraumatic stress disorder (PTSD), and mood and anxiety disorders.

1 Sep 2016

Parental psychiatric diseases may lead to risk for suicide attempts and violent offending by children

Risk for suicide attempts and violent offending by children appears to be associated with their parents' psychiatric disorders, according to an article published online by JAMA Psychiatry.

31 Aug 2016

Newly-developed epigenetic test can be used to identify tumors responsible for metastasis in cancer patient

In patients with cancer, initial diagnosis most often includes the detection of the primary or original tumor and the presence or absence of metastases, ie cells from the original tumor that have escaped from their original location and are growing into other tissues of the patient.

27 Aug 2016

Chromatrap develops new range of optimised ChIP assay kits for genetic research

Chromatrap is a pioneer in the development of solid-state filter-based technology that significantly enhances and accelerates the important epigenetic research tool of chromatin immunoprecipitation (ChIP).

From Chromatrap® - Porvair Sciences Ltd 26 Aug 2016

Protein complex could play key role in natural development of stem cells into healthy blood cells

A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis.

25 Aug 2016

Study shows Latinos age more slowly at molecular level than other ethnic groups

A new paper co-authored by a UC Santa Barbara researcher reveals that Latinos age at a slower rate than other ethnic groups. The findings, published in the current issue of Genome Biology, may one day help scientists understand how to slow the aging process for everyone.

24 Aug 2016

DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

Diseases such as epilepsy, neuropathic pain, anxiety, depression, drug addiction and Alzheimer's are all associated with changes in the excitability of brain neurons.

24 Aug 2016

Colorectal tumors present epigenetic heterogeneity, study finds

A new study led by Dr. Manel Esteller, Director of the Epigenetics and Cancer Biology Program of Bellvitge Biomedical Research Institute, ICREA researcher and Professor of Genetics at University of Barcelona discovers that colorectal tumors present epigenetic heterogeneity that relates to the clinical course of the disease.

18 Aug 2016

Maintaining proper oxygen supply in tumors could be key factor to stop progression of cancer

The lack of oxygen in tumor cells changes the cells' gene expression, thereby contributing to the growth of cancer.

18 Aug 2016

Poor prenatal nutrition may be linked to ADHD symptoms and conduct problems in children

New research led by scientists from King's College London and the University of Bristol has found that a high-fat, high-sugar diet during pregnancy may be linked to symptoms of ADHD in children who show conduct problems early in life.

18 Aug 2016

Latinos age more slowly than other ethnic groups, reveals UCLA study

A UCLA study is the first to show that Latinos age at a slower rate than other ethnic groups. The findings, published in the current issue of Genome Biology, may one day help scientists understand how to slow the aging process for everyone.

16 Aug 2016

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Researchers have used CRISPR -- a revolutionary new genetic engineering technique -- to convert cells isolated from mouse connective tissue directly into neuronal cells.

11 Aug 2016

Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

A novel PET radiotracer developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital is able for the first time to reveal epigenetic activity - the process that determines whether or not genes are expressed - within the human brain.

11 Aug 2016

Researchers reprogram skin cells from diabetic foot ulcers to generate iPSCs

The potential to use a patient's own cells to treat non-healing chronic wounds - a serious complication of diabetes - took an important step forward as researchers successfully reprogrammed skin cells taken from diabetic foot ulcers to form induced pluripotent stem cells (iPSCs).

10 Aug 2016

New laboratory model replicates early phase of Parkinson's before onset of motor symptoms

They're two of the biggest mysteries in Parkinson's disease research--where does the disease start? And how can it be stopped early in the process? Now, a new laboratory model of Parkinson's is giving scientists an inside look at what happens in the brain years before motor symptoms appear.

9 Aug 2016

New Sequins technology could help improve quality of genomic analysis

Australian genomics researchers have announced the development of Sequins -- synthetic 'mirror' DNA sequences that reflect the human genome.

9 Aug 2016

Review provides new insights into diagnosis, treatment for PCOS

Polycystic ovary syndrome (PCOS) afflicts over 14 million women in the United States. The disorder increases the risk of endometrial cancer, heart disease, high blood pressure, type 2 diabetes, asthma, obesity, depression and anxiety, as well as infertility and a variety of reproductive disorders.

4 Aug 2016

New study analyzes evolution of epigenetic mechanisms from bacteria to humans

After the emergence of single-celled organisms some billions of years ago, nature started experimenting with how to diversify gene function without changing the sequence of the DNA, such that the blue print remains conserved, but allows gene products to have different functions.

4 Aug 2016

Paternal over-nutrition may lead to generational obesity and metabolic dysfunction

Paternal intake of a high-fat diet (HFD) can cause genetic changes that lead to generational obesity and metabolic dysfunction—including body weight and fat mass increases and changes in blood pressure, triglyceride levels and fat metabolism—in mice, according to Japanese researchers at Okayama University.

2 Aug 2016

Study clarifies role of KLF12 in CRC tumor growth

Results of preclinical studies by MUSC investigators reported in the July 2016 issue of PLOS One, demonstrate for the first time that the transcription factor KLF12 promotes CRC cell growth, in part, by activating EGR1. Furthermore, data demonstrate that KLF12 and EGR1 levels synergistically correlate with poor CRC prognoses.

29 Jul 2016

Epigenetics News and Research

Further Reading

Epigenetic changes from stress exposure can be passed from traumatized parent to offspring

Parental psychiatric diseases may lead to risk for suicide attempts and violent offending by children

Newly-developed epigenetic test can be used to identify tumors responsible for metastasis in cancer patient

Chromatrap develops new range of optimised ChIP assay kits for genetic research

Protein complex could play key role in natural development of stem cells into healthy blood cells

Study shows Latinos age more slowly at molecular level than other ethnic groups

DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

Colorectal tumors present epigenetic heterogeneity, study finds

Maintaining proper oxygen supply in tumors could be key factor to stop progression of cancer

Poor prenatal nutrition may be linked to ADHD symptoms and conduct problems in children

Latinos age more slowly than other ethnic groups, reveals UCLA study

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

Researchers reprogram skin cells from diabetic foot ulcers to generate iPSCs

New laboratory model replicates early phase of Parkinson's before onset of motor symptoms

New Sequins technology could help improve quality of genomic analysis

Review provides new insights into diagnosis, treatment for PCOS

New study analyzes evolution of epigenetic mechanisms from bacteria to humans

Paternal over-nutrition may lead to generational obesity and metabolic dysfunction

Study clarifies role of KLF12 in CRC tumor growth

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