Fibroblast News and Research

RSS

Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

New research findings published in the Journal of Leukocyte Biology, suggest that synovial CD4+ T cells that produce IL-21 contribute to joint inflammation by activating synovial fibroblasts in rheumatoid arthritis patients.

2 Mar 2017

Researchers evaluate effects of laser tissue welding on spina bifida repair

In a study to be presented Saturday, Jan. 28, in the oral concurrent session at 8:45 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, researchers at Baylor College of Medicine, Houston, Texas; IBEX, Logan, Utah; and Laser Tissue Welding Inc., Houston, Texas collaborated on a study titled, Evaluation of the effects of laser tissue welding on the spinal cord and skin in a 30 day study of simulated spina bifida repair in rabbits.

23 Jan 2017

Lipid content changes as cells age, new study reveals

As cells age and stop dividing, their fat content changes, along with the way they produce and break down fat and other molecules classified as lipids, according to a new University at Buffalo study.

20 Jan 2017

Researchers uncover how stress hormone prevents digestive enzymes from damaging pancreas

UT Southwestern Medical Center researchers have uncovered the mechanism by which the stress hormone FGF21 keeps digestive enzymes from damaging the pancreas.

18 Jan 2017

Novel murine model helps shed light on mechanisms involved in reversible infantile liver failure

Reversible infantile liver failure (RILF) is a heritable mitochondrial condition that causes severe liver dysfunction in infancy, but those who survive the acute stage typically recover and have no further problems.

27 Dec 2016

Researchers pinpoint mechanism underlying astrocyte-mediated recovery of brain tissue after injury

A Kobe University research team has pinpointed the mechanism underlying astrocyte-mediated restoration of brain tissue after an injury. This could lead to new treatments that encourage regeneration by limiting damage to neurons incurred by reduced blood supply or trauma.

15 Dec 2016

Low-dose chemotherapy regimens may be more effective at treating certain breast and pancreatic cancer types

Conventional, high-dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors' recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.

24 Nov 2016

Research reveals key role of fibroblasts in development of rheumatoid arthritis

A study led by researchers at the University of Birmingham reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for research into treatment of the disease.

23 Nov 2016

Omega-3 fatty acids can stimulate activation of brown and beige adipose tissues, study finds

Omega-3 fatty acids are able to stimulate the activation of brown and beige adipose tissues, a discovery that would promote the development of new therapies for obesity and other metabolism diseases, according to a research study published in the journal Nature Communications under the supervision of Professor Francesc Villarroya, from the Department of Biochemistry and Molecular Biomedicine and the Biomedical Research Center Red-Fisiopatología de la Obesidad y Nutrición (CIBEROBN) of the Institute of Health Carlos III.

21 Nov 2016

New study identifies novel target for treatment of Graves' disease and other scarring eye conditions

A new class of therapies may be on the horizon for thyroid eye disease (TED) and other destructive scarring conditions.

11 Nov 2016

High-protein diets may help prevent chronic diseases by reducing liver fat

According to a new nutritional study conducted by the German Institute of Human Nutrition on individuals with type 2 diabetes, high-protein diets reduced liver fat by up to 48 percent within six weeks. It did not matter whether the diet was mainly based on plant or animal protein.

2 Nov 2016

New scaffold could improve outcome of periodontal regenerative surgery

A new regenerative scaffold made of biosafe collagen hydrogel and collagensponge could possess the ability of retaining fibroblastic growth factor-2 (FGF2) and stimulate the periodontal tissue regeneration, according to new research published in The Open Dentistry Journal.

24 Oct 2016

Research could lead to new therapeutic targets for suppressing tumor growth

A new study has identified a mechanism used by tumors to recruit stem cells from bone and convert them into cancer-associated fibroblasts (CAFs) that facilitate tumor progression.

21 Oct 2016

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

The first-in-human dose escalation study of the pan-FGFR (fibroblast growth factor receptor) inhibitor BAY 1163877 in patients with treatment-refractory locally advanced or metastatic solid tumours were reported today at the ESMO 2016 Congress in Copenhagen.

8 Oct 2016

New study reveals endocrine biological function of brown adipose tissue

Brown adipose tissue -main organ generating heat in the body- is also an endocrine organ that secretes signaling factors that activate the fat and carbohydrates metabolism.

28 Sep 2016

De-bookmarking could be key to better reprogramming of fibroblasts into iPS cells

In reading, a bookmark tells where you stopped. Cells use bookmarks too, specific proteins that help the cell remember what collection of genes needs to be turned on again after the brief halt of gene expression during cell division.

20 Sep 2016

Cold plasma therapy may help treat non-healing wounds

Russian scientists at the Moscow Institute of Physics and Technology, the Joint Institute for High Temperatures of the Russian Academy of Sciences, and Gamaleya Research Centre of Epidemiology and Microbiology found that treating cells with cold plasma leads to their regeneration and rejuvenation.

13 Sep 2016

New stem-cell model of heart tissue unravels mechanisms linked to hypertrophic cardiomyopathy

Using advanced stem cell technology, scientists from the Icahn School of Medicine at Mount Sinai have created a model of a heart condition called hypertrophic cardiomyopathy (HCM) — an excessive thickening of the heart that is associated with a number of rare and common illnesses, some of which have a strong genetic component.

31 Aug 2016

Researchers reprogram skin cells from diabetic foot ulcers to generate iPSCs

The potential to use a patient's own cells to treat non-healing chronic wounds - a serious complication of diabetes - took an important step forward as researchers successfully reprogrammed skin cells taken from diabetic foot ulcers to form induced pluripotent stem cells (iPSCs).

10 Aug 2016

New study shows how the body’s biological clock suppresses inflammation during night-time sleep

New research published online in The FASEB Journal, describes a protein created by the body's "biological clock" that actively represses inflammatory pathways within the affected limbs during the night.

8 Aug 2016