Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Omicron BA.5 variant demonstrates increased neuroinvasiveness and pathogenicity in mice

Researchers assessed the extent of SARS-CoV-2 Omicron VOC BA.5 sub-VOC infection-associated brain infection and death.

5 Apr 2023

New imaging technique can improve the treatment of intestinal strictures in Crohn's disease

Patients suffering from Crohn's disease, a chronic inflammatory intestinal disorder, develop painful constrictions in the bowel.

5 Apr 2023

Advanced pancreatic cancer model more accurately depicts PDAC tumor progression

Pancreatic ductal adenocarcinoma (PDAC), is highly aggressive and lethal. It is the most prevalent type of pancreatic cancer, making up 90% of cases; it also has a high rate of metastasis, with an average five-year survival rate of less than 10%.

29 Mar 2023

3D cell culture system tests how inhibiting fibroblast activities can help treat lung cancer

Fibroblasts build and maintain the extracellular matrix, or physical scaffolding for cells, in the connective tissues within the body.

28 Mar 2023

New biomimetic model helps study wound healing in burn and laceration wounds

Burn wounds are notoriously prone to bacterial infection and typically lead to a larger amount of scar tissue than laceration wounds.

15 Mar 2023

An emerging target for chronic kidney disease treatment - DNA-PKcs

A recent Nature Communications study suggested that DNA-PKcs could be a potential target for treating chronic kidney disease.

15 Mar 2023

Spike-induced humoral immunity and its association with antibody-dependent cellular cytotoxicity potency

A new study aimed to analyze the qualitative and quantitative impact of S-induced humoral immunity along with its ADCC capability in individuals who received a vaccination, recovered from an infection, or both.

14 Mar 2023

Distinct microbial profile present in intrahepatic cholestasis of pregnancy patients

Researchers assessed the impact of the gut microbiome on the host's bile acid metabolism and intrahepatic cholestasis of pregnancy (ICP).

14 Mar 2023

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

Researchers observe persistent SARS-CoV-2 replication in severe COVID-19 patient lungs.

13 Mar 2023

A shot of liver-produced hormone sobers up drunk mice

A hormone called fibroblast growth factor 21 (FGF21) protects mice against ethanol-induced loss of balance and righting reflex, according to a study publishing on March 7 in the journal Cell Metabolism.

7 Mar 2023

Study identifies the essential genetic and immunologic perturbations occurring in patients with long COVID lung fibrosis

Researchers elucidated immunologic and genetic perturbations in long COVID patients with pulmonary fibrosis.

3 Mar 2023

Researchers use spatial single-cell transcriptome technique to examine immune signatures of SARS-CoV-2-infected lungs

The study findings demonstrate the power of spatial single-cell transcriptomics in studying COVID-19 lung pathology and other health and disease conditions.

1 Mar 2023

Discovery of a T cell subset points to new treatment for COPD exacerbations

Respiratory viral infections pose significant morbidity and mortality to patients with chronic lung diseases like emphysema and COPD, causing exacerbations that drive destruction of normal lung tissue, and leading to one of the most common diagnoses for hospital admissions.

24 Feb 2023

Fibroblast News and Research

Further Reading

Omicron BA.5 variant demonstrates increased neuroinvasiveness and pathogenicity in mice

New imaging technique can improve the treatment of intestinal strictures in Crohn's disease

Advanced pancreatic cancer model more accurately depicts PDAC tumor progression

3D cell culture system tests how inhibiting fibroblast activities can help treat lung cancer

New biomimetic model helps study wound healing in burn and laceration wounds

An emerging target for chronic kidney disease treatment - DNA-PKcs

Spike-induced humoral immunity and its association with antibody-dependent cellular cytotoxicity potency

Distinct microbial profile present in intrahepatic cholestasis of pregnancy patients

SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19

A shot of liver-produced hormone sobers up drunk mice

Study identifies the essential genetic and immunologic perturbations occurring in patients with long COVID lung fibrosis

Researchers use spatial single-cell transcriptome technique to examine immune signatures of SARS-CoV-2-infected lungs

Discovery of a T cell subset points to new treatment for COPD exacerbations

Whole-genome CRISPR activation for the identification of host factors controlling cellular interactions with SARS-CoV-2

Scientists discover a protein in the lung that blocks SARS-CoV-2 infection

Research reveals the cellular origin of cancer-associated fibroblasts

The loss of epigenetic information accelerates the aging process

Can diets reverse or delay aging?

CU researchers discover a new mechanism for slowing cardiac fibrosis

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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