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Fibrosis is the growth of fibrous tissue.

Scientists use exome sequencing method to discover the cause of mendelian disorder

20. November 2009 03:27
For the first time, scientists have successfully used a method called exome sequencing to quickly discover a previously unknown gene responsible for a mendelian disorder. [More]

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Green tea prevents the development of hepatic fibrosis in rat model of DMN-induced liver fibrosis

18. November 2009 10:24
Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis and alcohol induced liver fibrosis were reported in many studies. However, the hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models has not been studied. [More]

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On-going Phase 2b study conducted by Roche of ITMN-191 modified

18. November 2009 03:55
InterMune, Inc. today announced that the on-going Phase 2b study conducted by Roche of ITMN-191 (RG7227) combined with standard of care (SOC) PEGASYS® (peginterferon alfa-2a) and COPEGUS® (ribavirin) in HCV treatment-naive patients has been modified. [More]

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Study to test anti-tumor effects of AEOL 10150 initiated

18. November 2009 03:04
Aeolus Pharmaceuticals, Inc. announced today the initiation of a study to test the anti-tumor effects of AEOL 10150 when combined with radiation and chemotherapy in nude mice bearing human non-small cell lung cancer (NSCLC) xenografts. [More]

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Abbott and BG Medicine announce a development and commercialization agreement for galectin-3 biomarker

17. November 2009 11:24
Abbott and BG Medicine, Inc. today announced a development and commercialization agreement for galectin-3, a novel biomarker that may play a role in detecting the development and progression of heart failure. The assay will be developed for Abbott's ARCHITECT immunochemistry instrument platform, specifically the company's i1000SR and i2000SR instruments. The agreement grants Abbott a license to BG Medicine's intellectual property related to galectin-3. [More]

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Consortium to define new modalities for treating hypertension and associated vascular complications

17. November 2009 05:25
Top Institute Pharma has formed a consortium with Actelion Pharmaceuticals Ltd, Erasmus Medical Centre and Maastricht University to define new modalities for the treatment of hypertension (high blood pressure) and associated vascular complications such as heart and kidney failure, myocardial infarction and stroke. [More]

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Antioxidant found in vegetables can protect cells from damage caused by infection and injury

17. November 2009 01:29
Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis (CF), diabetes, heart disease, and neurodegeneration. [More]

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Aradigm commences patient dosage in Phase 2 trial of novel inhaled ciprofloxacin formulation

16. November 2009 08:05
Aradigm Corporation today announced that the first patient was dosed in a 6-month, multicenter, international Phase 2 clinical trial of a novel version of inhaled ciprofloxacin (ARD-3150) in 40 adult patients with non-cystic fibrosis bronchiectasis. [More]

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Pro-Pharmaceuticals announces financial results for the third quarter and first nine months of fiscal 2009

13. November 2009 09:14
Pro-Pharmaceuticals, Inc., a developer of galectin-targeted, carbohydrate therapeutic compounds to treat cancer and fibrosis, today reported its financial results for the third quarter and first nine months of fiscal 2009. These results are included in the Company’s Quarterly Report on Form 10-Q for the three- and nine-month periods ended September 30, 2009, which has been filed with the SEC. [More]

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New updated education course from PARI Respiratory Equipment

13. November 2009 02:05
Today, PARI Respiratory Equipment launched a newly updated continuing education class, Managing Respiratory Patients Through Efficient Aerosol Delivery, rounding out their free learning program with seven classes for respiratory therapists, nurses, case managers, and pharmacists. [More]

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Transplantation of human mononuclear cells exerts a deleterious effect in rats with liver cirrhosis

12. November 2009 10:37
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the universities of Granada and León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis. [More]

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Research and Markets' Competitive Intelligence Report on TGF-R agonists and antagonists

11. November 2009 07:53
Research and Markets has announced the addition of the "Competitor Analysis: TGF-R Agonists and Antagonists" report to their offering. [More]

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Vertex Pharmaceuticals announces exchange agreement with holders of its 4.75% Convertible Senior Subordinated Notes

11. November 2009 06:19
Vertex Pharmaceuticals Incorporated announced today that holders of its 4.75% Convertible Senior Subordinated Notes due 2013 have agreed to exchange approximately $109.0 million in aggregate principal amount of those notes and accrued interest for approximately 4.8 million shares of the Company’s common stock, which is approximately 140,000 shares more than the number of shares into which the notes were convertible under their original terms. [More]

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Covidien contraindicates use of its Optimark gadoversetamide injection

9. November 2009 09:14
Covidien, a leading global provider of healthcare products, today announced that it will voluntarily contraindicate the use of its Optimark™ gadoversetamide injection, a gadolinium-based contrast agent (GBCA), in magnetic resonance imaging (MRI) procedures involving patients with severe renal impairment. [More]

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Bend Research signs collaboration agreement with Vertex Pharmaceuticals

9. November 2009 06:08
Bend Research Inc., a company with more than 30 years of experience in applying innovative pharmaceutical technologies to help clients solve their most difficult scientific and technical problems, announced today that it has entered into a collaboration with Vertex Pharmaceuticals Incorporated, a global biotechnology company headquartered in Cambridge, MA. [More]

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