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Scientists develop statistical models to predict which drug is best for specific disease

Medicines that are personally tailored to your DNA are becoming a reality, thanks to the work of U.S. and Chinese scientists who developed statistical models to predict which drug is best for a specific individual with a specific disease.

17 Jul 2013

Scientists develop histology expression predictor for most common types of lung cancer

Knowing what type of lung cancer a patient has is critical to determine which drug will work best and which therapies are safest in the era of personalized medicine. Key to making that judgment is an adequate tumor specimen for the pathologist to determine the tumor's histology, a molecular description of a tumor based on the appearance of cells under a microscope.

17 Jul 2013

Smokers who seem healthy have damaged airway cells similar to cells found in aggressive lung cancer

Smokers who've received a clean bill of health from their doctor may believe cigarettes haven't harmed their lungs. However, researchers at Weill Cornell Medical College have found that even smokers who seem healthy have damaged airway cells, with characteristics similar to cells found in aggressive lung cancer.

17 Jul 2013

Drug to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy

A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle--a disorder that often leads to heart failure, researchers at the University of Illinois at Chicago College of Medicine report.

17 Jul 2013

Study demonstrates effectiveness of everolimus for TSC patients

A drug originally developed to prevent the rejection of transplanted organs has now been shown to dramatically reduce seizures in patients with tuberous sclerosis complex - a genetic disease characterized by benign tumors on multiple organ systems.

16 Jul 2013

UAB researchers study link between sleep and pain among patients with knee osteoarthritis

Researchers at the University of Alabama at Birmingham want to know more about the relationship between sleep and pain.

16 Jul 2013

Largest data set of cancer-specific genetic variations generated by NCI scientists

Scientists at the National Cancer Institute have generated a data set of cancer-specific genetic variations and are making these data available to the research community, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

16 Jul 2013

Researchers develop new test to detect E. coli at food processing facilities

Medical, agriculture and computer science researchers from the University of Alberta have teamed up to develop a test that will make Canadians feel safer about the meat they put on their tables.

16 Jul 2013

Pair of studies sheds light on cancer cell signaling

A pair of studies by a team of University of Notre Dame researchers led by Crislyn D'Souza-Schorey, professor of biological sciences, sheds light on a biological process which is activated across a vast range of malignancies.

16 Jul 2013

White blood cells and the spread of cancer: an interview with Drs. Lorenzo Ferri and Jonathan Cools-Lartigue, McGill University

As surgeons who take care of cancer patients, we have observed a troubling association between patients who suffer from infections after surgery and the rapid spread of their cancer. We have reported this in lung cancer patients, and others have made these observations in a variety of different cancers. However, the mechanisms responsible for this association are still poorly understood.

16 Jul 2013

Researchers identify genes that allow animal hepatitis E virus strains to infect humans

X.J. Meng, a University Distinguished Professor at Virginia Tech and a virologist at the Virginia-Maryland Regional College of Veterinary Medicine, has received a four-year, nearly $1.6 million grant from the National Institutes of Health to better understand the genetic elements that allow hepatitis E virus to transfer from animals to people.

16 Jul 2013

CUMC researchers develop new approach to tailor cancer therapy for individual patient

Columbia University Medical Center (CUMC) researchers are developing a new approach to cancer clinical trials, in which therapies are designed and tested one patient at a time.

16 Jul 2013

Researchers discover that JNK3 expression is downregulated at early stages of traumatic brain injury

Increasing evidence has revealed that the activation of the JNK pathway participates in apoptosis of nerve cells and neurological function recovery after traumatic brain injury.

16 Jul 2013

Researchers distinguish viral and bacterial infections in children with fever

In children with fever but no other symptoms of illness, it is difficult to know whether a child has a viral infection that will resolve on its own or a potentially serious bacterial infection that requires antibiotics.

16 Jul 2013

Scientists discover how BRCA1 gene mutations predispose women to breast and ovarian cancers

Scientists led by Drs. Mona Gauthier and Tak Mak at The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre have solved a key piece in the puzzle of how BRCA1 gene mutations specifically predispose women to breast and ovarian cancers.

16 Jul 2013

Proteins involved in immunity produce cancer-causing DNA mutations, study finds

A set of proteins involved in the body's natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. The findings suggest that these naturally produced mutations are just as powerful as known cancer-causing agents in producing tumors.

15 Jul 2013

High folate intake during pregnancy may have undiscovered later-life effect in progeny

During pregnancy, women are normally advised to take high amounts of multivitamin supplements. In particular, folate is recommended to reduce the risk of neural tube defects in newborns. The problem is that, although vitamins are critical in fetal development, high vitamin doses during pregnancy may cause undesired effects on the offspring later in life.

15 Jul 2013

New discovery reveals how RNA moves genetic information from DNA to create proteins

The discovery cracks the "RNA control code," which dictates how RNA - a family of molecules that mediates DNA expression - moves genetic information from DNA to create proteins.

15 Jul 2013

New theory challenges orthodox view that cancer develops in each host by mutational accidents

A new way to look at cancer -- by tracing its deep evolutionary roots to the dawn of multicellularity more than a billion years ago -- has been proposed by Paul Davies of Arizona State University's Beyond Center for Fundamental Concepts in Science in collaboration with Charles Lineweaver of the Australian National University.

15 Jul 2013

'Defanged' HIV used to deliver gene therapy

Researchers are having success using a "defanged" version of HIV to deliver gene therapy to children suffering from genetic diseases, a development that could improve other such care.

15 Jul 2013

Genes News and Research

Scientists develop statistical models to predict which drug is best for specific disease

Scientists develop histology expression predictor for most common types of lung cancer

Smokers who seem healthy have damaged airway cells similar to cells found in aggressive lung cancer

Drug to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy

Study demonstrates effectiveness of everolimus for TSC patients

UAB researchers study link between sleep and pain among patients with knee osteoarthritis

Largest data set of cancer-specific genetic variations generated by NCI scientists

Researchers develop new test to detect E. coli at food processing facilities

Pair of studies sheds light on cancer cell signaling

White blood cells and the spread of cancer: an interview with Drs. Lorenzo Ferri and Jonathan Cools-Lartigue, McGill University

Researchers identify genes that allow animal hepatitis E virus strains to infect humans

CUMC researchers develop new approach to tailor cancer therapy for individual patient

Researchers discover that JNK3 expression is downregulated at early stages of traumatic brain injury

Researchers distinguish viral and bacterial infections in children with fever

Scientists discover how BRCA1 gene mutations predispose women to breast and ovarian cancers

Proteins involved in immunity produce cancer-causing DNA mutations, study finds

High folate intake during pregnancy may have undiscovered later-life effect in progeny

New discovery reveals how RNA moves genetic information from DNA to create proteins

New theory challenges orthodox view that cancer develops in each host by mutational accidents

'Defanged' HIV used to deliver gene therapy

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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