Genotyping News and Research

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Scientists discover reservoir of mitochondrial DNA mutations present in the general population

Researchers at the University of Newcastle, England, and the Virginia Bioinformatics Institute at Virginia Tech in the United States have revealed a large reservoir of mitochondrial DNA mutations present in the general population. Clinical analysis of blood samples from almost 3,000 infants born in north Cumbria, England, showed that at least 1 in 200 individuals in the general public harbor mitochondrial DNA mutations that may lead to disease.

11 Aug 2008

AutoGenomics issued European patent for Human papillomavirus

AutoGenomics has announced that it has been issued a key European patent for Human papillomavirus.

19 Jun 2008

Three sequencing companies join 1000 Genomes Project

Leaders of the 1000 Genomes Project announced today that three firms that have pioneered development of new sequencing technologies have joined the international effort to build the most detailed map to date of human genetic variation as a tool for medical research. The new participants are: 454 Life Sciences, a Roche company, Branford, Conn.; Applied Biosystems, an Applera Corp. business, Foster City, Calif.; and Illumina Inc., San Diego.

11 Jun 2008

Cutting unnecessary treatment for blood disorder in pregnancy

A new test for identifying a mismatch between the blood of a pregnant woman and her baby is accurate, feasible, and could substantially reduce unnecessary treatment, finds a Bristol study published on bmj.com.

9 Apr 2008

New test could cut unnecessary treatment for blood disorder in pregnancy

A new test for identifying a mismatch between the blood of a pregnant woman and her baby is accurate, feasible, and could substantially reduce unnecessary treatment, finds a study published on bmj.com.

4 Apr 2008

Marketing of unproven genetic tests a threat to public health

No mechanism currently exists to ensure that genetic tests are supported by adequate evidence before they go to market, or that marketing claims are truthful and not misleading, according to a policy analysis to be published April 4 in Science.

4 Apr 2008

Genetic variations raise lung cancer risk for smokers and ex-smokers

Two common inherited genetic variations are associated with increased risk of lung cancer for smokers and former smokers, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports April 2 in the online edition of Nature Genetics.

3 Apr 2008

Wistar Institute shares cell lines

Cell lines developed by scientists at The Wistar Institute in Philadelphia have recently been made available to researchers around the globe through the catalog collection at the Coriell Institute for Medical Research of Camden, N.J.

26 Mar 2008

Cholesterol-associated gene variants can predict cardiovascular events

A study appearing in this week's New England Journal of Medicine confirms that a combination of gene variants previously associated with cholesterol levels does reflect patients' cholesterol levels and can signify increased risk of heart attack, stroke or sudden cardiac death.

20 Mar 2008

Multiple approaches to type 1 diabetes

Type 1 diabetes, formerly called insulin-dependent diabetes, juvenile diabetes or childhood-onset diabetes, affects 1 to 2 million people in the U.S. and millions more worldwide.

21 Feb 2008

Genotyping and the treatment of alcohol dependence

Inherited genetic makeup often plays a role in determining the risk level for certain diseases, including alcoholism.

8 Feb 2008

Gene variations associated with effectiveness of blood pressure medications

Patients with hypertension and certain gene variations experienced varying results with some blood pressure medications, suggesting matching a patient's genotype with certain hypertension medications could result in more favorable outcomes, according to a study in the January 23 issue of JAMA: The Journal of the American Medical Association.

23 Jan 2008

Genetics behind the disease systemic lupus erythematosus almost completed

A new study has mapped the risk factors behind the autoimmune disease SLE in the entire human genome.

22 Jan 2008

New method to identify genetic determinants of Alzheimer's

A rapid and accurate DHPLC assay for determination of apolipoprotein E genotypes has been developed by researchers from the Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

14 Jan 2008

Variant of COMT gene linked to impulsive decisions

People with clinical addictions know first-hand the ravages the disease can take on almost every aspect of their lives.

28 Dec 2007

Brain imaging shows there may be a cognitive difference in people with addictions

Scientists have for the first time identified brain sites that fire up more when people make impulsive decisions.

28 Dec 2007

WaferGen and University of Pittsburgh to collaborate on SmartChip

WaferGen Biosystems, Inc. has announced that it has established a research collaboration with the University of Pittsburgh Medical School to have it serve as the alpha test site for WaferGen's SmartChip Real-Time PCR System.

14 Nov 2007

Cause of leptospirosis outbreak in Thailand discovered

A single disease-causing clone of the bacterium Leptospira interrogans was behind the recent sustained outbreak of leptospirosis in Thailand, according to a new collaborative investigation by researchers in Thailand, Australia, and the UK.

31 Oct 2007

Affymetrix files more patent infringements against Illumina in U.S. and Europe

Affymetrix Inc. has announced that it has filed additional patent infringement lawsuits against Illumina Inc. in the United States District Court for the District of Delaware, in the U.K. High Court of Justice, Chancery Division, Patents Court and in the German, Düsseldorf Regional Court, Patent Division. Affymetrix is seeking all available remedies, including injunctive relief.

From Illumina, Inc. 24 Oct 2007

Discovery of two genes linked to a disabling form of arthritis called ankylosing spondylitis

An international team of researchers led by a Fred Hutchinson Cancer Research Center geneticist has discovered two genes linked to a disabling form of arthritis called ankylosing spondylitis, a painful and progressive disease in which some or all of the spine's vertebrae fuse together.

22 Oct 2007