Ghrelin News and Research

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Ghrelin is a hormone produced mainly by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas that stimulates appetite. Ghrelin levels increase before meals and decrease after meals. It is considered the counterpart of the hormone leptin, produced by adipose tissue, which induces satiation when present at higher levels. Ghrelin is also produced in the hypothalamic arcuate nucleus where it stimulates the secretion of growth hormone from the anterior pituitary gland.

Diabetes Care journal features comprehensive EndoBarrier meta-analysis

GI Dynamics Inc., a medical device company that is developing EndoBarrier for patients with type 2 diabetes and obesity, is pleased to announce the meta-analysis, "Effects of the Duodenal-Jejunal Bypass Liner on Glycemic Control in Type 2 Diabetic Patients with Obesity: A Meta-analysis with Secondary Analysis on Weight Loss and Hormonal Changes," by Pichamol Jirapinyo, MD, of Brigham and Women's Hospital in Boston, Massachusetts, and Diplomat of the American Board of Obesity Medicine, has been published in Diabetes Care, the journal of the American Diabetes Association.

10 May 2018

Study helps explain why people feel hungrier after weight loss

A new study has helped to explain why people who lose a lot of weight find it difficult to maintain a healthy diet in the long term.

8 Feb 2018

Injections of hunger hormone blocker can halt typical weight gain in mice

Mayo Clinic scientists have shown that injections of a hunger hormone blocker in mice can halt the typical weight gain after dieting and help prevent rebound obesity in the long term. The research findings appear in the Proceedings of the National Academy of Sciences.

26 Sep 2017

Good sleep linked to reduction in psychological problems

According a new study lack of sleep can actually contribute to mental health problems as suspected earlier. The study aimed to see if improvement in sleep could help reduce psychological problems such as paranoia and hallucinations. The study termed OASIS (Oxford Access for Students Improving Sleep) was a randomized controlled trial that involved 26 universities in the United Kingdom. The study was published in the latest issue of the journal Lancet Psychology.

6 Sep 2017

Synthetic molecule can disrupt hunger-signaling pathway, research suggests

New research suggests that a man-made cousin of a small molecule found in olive oil can disrupt the hunger-signaling pathway.

27 Jul 2017

Delayed eating can increase weight and negatively affect fat metabolism

New findings suggest eating late at night could be more dangerous than you think. Compared to eating earlier in the day, prolonged delayed eating can increase weight, insulin and cholesterol levels, and negatively affect fat metabolism, and hormonal markers implicated in heart disease, diabetes and other health problems, according to results from researchers at the Perelman School of Medicine at the University of Pennsylvania.

2 Jun 2017

UT Southwestern study sheds light on role of hormone ghrelin in blood glucose control

UT Southwestern research investigating the blood glucose-regulatory actions of the hormone ghrelin may have implications for development of new treatments for diabetes.

10 May 2017

Newly discovered molecule plays central role in appetite control mechanisms

A newly discovered molecule increases appetite during fasting -- and decreases it during gorging. The neuron-exciting protein, named NPGL - apparently aims to maintain body mass at a constant, come feast or famine. An evolutionary masterstroke, but not great news for those looking to trim down -- or beef up for the summer.

28 Apr 2017

Scientists target hunger's complex chemistry to yield promising treatments for obesity

Discoveries of hormones related to weight and appetite in the '90s helped spur a search for obesity treatments targeting those hormones-- with disappointing results.

29 Mar 2017

Food: the good, the bad and the ugly

As a society, we may be more obsessed with food than we've ever been. The alarming levels of obesity along with the rise of clean eating and orthorexia are perhaps just some indicators of the food-obsessed world we live in.

2 Feb 2017

Researchers uncover how brain circuit elicits hunger responses during starvation

The human body responds to starving conditions, such as famine, to promote the chance of survival. It reduces energy expenditure by stopping heat production and promotes feeding behavior.

27 Jan 2017

Physician explains how poor or low-quality sleep hinders common resolutions

Making New Year's resolutions is easy. Keeping them — beyond a couple of weeks, at least — is tough.

20 Jan 2017

Sleep-deprived people may consume extra calories , study finds

Sleep deprivation may result in people consuming more calories during the following day, according to a systematic review and meta-analysis led by researchers at King's College London.

2 Nov 2016

AgriLife scientists examine role of ghrelin receptor in age-related adipose tissue inflammation in mice

Scientists have proposed that inflammation is the harbinger of aging and central to the aging process, a phenomenon described as 'inflamm-aging,' said Dr. Yuxiang Sun.

24 Aug 2016

Researchers discover new role of cellular signaling molecule involved in release of hunger hormone

Researchers at UT Southwestern Medical Center have identified a previously unknown role of a cellular signaling molecule involved in release of the "hunger hormone" ghrelin, a finding that could have implications for optimal treatment of children taking beta blockers.

23 Aug 2016

Increased production of feeling full hormone linked to reduced hunger and food intake in elderly people

A preliminary study might hold the key to why over-80s are prone to losing weight.

5 Aug 2016

Soy-ghretropin protein increases ghrelin levels and improves appetite

Researchers have discovered a protein that stimulates secretion of ghrelin, an appetite-stimulating hormone produced in the stomach.

19 Jul 2016

AMPK protein activated during fasting regulates hunger neurons in the brain

Neurons in the brain that control hunger are regulated by AMPK, a protein activated during fasting, report researchers from Tufts University School of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School in Neuron on July 6, 2016.

6 Jul 2016

CHLA study provides novel insights into the brain mechanisms linked to Prader-Willi syndrome

A study published in the journal Human Molecular Genetics by researchers at Children's Hospital Los Angeles provides novel insights into the brain mechanisms underlying the insatiable hunger and subsequent obesity in patients with Prader-Willi syndrome.

15 Jun 2016

Increasing ghrelin levels during hunger can negatively affect decision making capabilities

Never make a decision when you are hungry. The hormone ghrelin - that is released before meals and known to increase appetite - has a negative effect on both decision making and impulse control. Such were the results of a recently conducted study at Sahlgrenska University.

10 May 2016