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Treating cancer cells with quizartinib inhibits key metabolic pathway, activates macroautophagy

Treating cancer cells with quizartinib inhibits key metabolic pathway, activates macroautophagy

A study published in The Journal of Cell Biology describes a way to force cancer cells to destroy a key metabolic enzyme they need to survive. [More]
Defects in mitochondria play key role in transition of normal cells to cancerous cells

Defects in mitochondria play key role in transition of normal cells to cancerous cells

Cancer cells defy the rules by which normal cells abide. They can divide without cease, invade distant tissues and consume glucose at abnormal rates. [More]
Tests reveal that FY26 cancer drug is 49 times more potent than Cisplatin drug

Tests reveal that FY26 cancer drug is 49 times more potent than Cisplatin drug

Tests have shown that a new cancer drug, FY26, is 49 times more potent than the clinically used treatment Cisplatin. [More]
SLU researchers find way to stop growth of cancer cells by targeting the Warburg Effect

SLU researchers find way to stop growth of cancer cells by targeting the Warburg Effect

In research published in Cancer Cell, Thomas Burris, Ph.D., chair of pharmacology and physiology at Saint Louis University, has, for the first time, found a way to stop cancer cell growth by targeting the Warburg Effect, a trait of cancer cell metabolism that scientists have been eager to exploit. [More]
High fructose consumption can lead to uncontrolled growth of cardiomyocytes, heart attack

High fructose consumption can lead to uncontrolled growth of cardiomyocytes, heart attack

'Walk through any supermarket and take a look at the labels on food products, and you'll see that many of them contain fructose, often in the form of sucrose (table sugar)' -- that's how Wilhelm Krek, professor for cell biology at ETH Zurich's Institute for Molecular Health Sciences, summarises the problem with today's nutrition. [More]
Calorie restriction can improve muscle metabolism during middle age

Calorie restriction can improve muscle metabolism during middle age

Calorie restriction has long been studied as a way to extend lifespan in animals. It has been associated with the ability to reduce the risks of cardiovascular and other diseases and to improve overall health. [More]
Metabolic derangement may facilitate cell proliferation in PAH

Metabolic derangement may facilitate cell proliferation in PAH

An enzyme that facilitates modification of proteins via a glucose metabolism pathway may promote cell proliferation in the lung tissue of patients with idiopathic pulmonary arterial hypertension, say researchers. [More]
Xylem’s YSI biochemistry analyzer is effective tool for cell culture and cancer research

Xylem’s YSI biochemistry analyzer is effective tool for cell culture and cancer research

Specifically for oncology drug development applications, the YSI 2950 biochemistry analyzer is used to measure analytes such as glucose, glutamine, glutamate, lactate, providing a simple, automated analysis of bioprocess cell culture samples, with accurate results in less than a minute. [More]
Researchers find unusual role of lactate in metabolism of alveolar soft part sarcoma

Researchers find unusual role of lactate in metabolism of alveolar soft part sarcoma

Researchers from Huntsman Cancer Institute at the University of Utah discovered the unusual role of lactate in the metabolism of alveolar soft part sarcoma (ASPS), a rare, aggressive cancer that primarily affects adolescents and young adults. The study also confirmed that a fusion gene is the cancer-causing agent in this disease. [More]
AMSBIO signs strategic marketing agreement with Luxcel Biosciences

AMSBIO signs strategic marketing agreement with Luxcel Biosciences

AMSBIO has signed a strategic marketing agreement with Luxcel Biosciences to distribute their range of 96- and 384-well phosphorescence and fluorescence based assays. [More]
AZD3965 drug inhibits growth of tumours in the lab

AZD3965 drug inhibits growth of tumours in the lab

Manchester scientists have shown that a new drug inhibits the growth of tumours in the lab and that its effectiveness is improved by combining it with radiotherapy - suggesting a new approach that could be used in the clinic. [More]
Game theory and the cancer ecosystem: an interview with Professor Pienta, Johns Hopkins

Game theory and the cancer ecosystem: an interview with Professor Pienta, Johns Hopkins

The classic description of game theory was described by the prisoner's dilemma, which is a situation in which two players have two options where the outcome depends on the simultaneous choice made by the other. [More]
AZD3965 drug could prove useful in treating small cell lung cancer

AZD3965 drug could prove useful in treating small cell lung cancer

Manchester scientists have shown that a new drug could prove useful in treating small cell lung cancer - the most aggressive form of lung cancer. [More]
New drug could prove useful in treating small cell lung cancer

New drug could prove useful in treating small cell lung cancer

Manchester scientists have shown that a new drug could prove useful in treating small cell lung cancer - the most aggressive form of lung cancer. [More]
18F-FGD-PET measures predict mRCC TKI response

18F-FGD-PET measures predict mRCC TKI response

Positron emission tomography could be used to predict the response of metastatic renal cell carcinoma to tyrosine kinase inhibitor therapy within a couple of weeks of a patient beginning treatment, research suggests. [More]
Endocrine Society announces winners of Early Investigators Awards and FLARE Internship Awards

Endocrine Society announces winners of Early Investigators Awards and FLARE Internship Awards

The Endocrine Society is pleased to announce the recipients of the 2014 Early Investigators Awards and the Future Leaders Advancing Research in Endocrinology Internship Awards. [More]
Study reveals how ovarian cancer metabolism changes between early, late stages

Study reveals how ovarian cancer metabolism changes between early, late stages

A Rice University-led analysis of the metabolic profiles of hundreds of ovarian tumors has revealed a new test to determine whether ovarian cancer cells have the potential to metastasize, or spread to other parts of the body. The study also suggests how ovarian cancer treatments can be tailored based on the metabolic profile of a particular tumor. [More]
B1/Cdk1 protein which plays key role in cell division also boosts power of mitochondrial activity

B1/Cdk1 protein which plays key role in cell division also boosts power of mitochondrial activity

​An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process. [More]
Targeting enzyme responsible for glucose metabolism halts tumor growth, say researchers

Targeting enzyme responsible for glucose metabolism halts tumor growth, say researchers

Cancer cells generate energy differently than normal cells, a characteristic that helps them to survive and metastasize. A major goal in the field of cancer metabolism is to find ways to overcome this survival advantage. [More]
Proteins that regulate energy metabolism are essential for stem cell formation

Proteins that regulate energy metabolism are essential for stem cell formation

Proteins that regulate energy metabolism are essential for stem cell formation, University of Washington researchers find. [More]
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