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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.
Genetically modified neural stem cells offer potential treatment for Alzheimer's disease

Genetically modified neural stem cells offer potential treatment for Alzheimer's disease

UC Irvine neurobiologists have found that genetically modified neural stem cells show positive results when transplanted into the brains of mice with the symptoms and pathology of Alzheimer's disease. The pre-clinical trial is published in the journal Stem Cells Research and Therapy, and the approach has been shown to work in two different mouse models. [More]
New lab at the Nencki Institute conducts research on neurodegenerative diseases

New lab at the Nencki Institute conducts research on neurodegenerative diseases

The Laboratory of Preclinical Studies of Higher Standard, the newest lab of the Neurobiology Center at the Nencki Institute in Warsaw, Poland, will conduct basic research aimed to explain molecular mechanisms responsible for neurodegenerative diseases. [More]
DNA modifications in blood are directly related to changes in brain tissues, say researchers

DNA modifications in blood are directly related to changes in brain tissues, say researchers

Johns Hopkins researchers say they have confirmed suspicions that DNA modifications found in the blood of mice exposed to high levels of stress hormone — and showing signs of anxiety — are directly related to changes found in their brain tissues. [More]

Caffeine has positive effect on tau deposits in Alzheimer's disease

As part of a German-French research project, a team led by Dr. Christa E. Müller from the University of Bonn and Dr. David Blum from the University of Lille was able to demonstrate for the first time that caffeine has a positive effect on tau deposits in Alzheimer's disease. [More]
Neuroinflammation levels higher in patients with chronic fatigue syndrome

Neuroinflammation levels higher in patients with chronic fatigue syndrome

Researchers at the RIKEN Center for Life Science Technologies, in collaboration with Osaka City University and Kansai University of Welfare Sciences, have used functional PET imaging to show that levels of neuroinflammation, or inflammation of the nervous system, are higher in patients with chronic fatigue syndrome than in healthy people. [More]
Study reveals role of dopamine in hippocampus region of brain

Study reveals role of dopamine in hippocampus region of brain

Bruno Giros, PhD, a researcher at the Douglas Mental Health University Institute and a professor in the Department of Psychiatry at McGill University, has demonstrated, for the first time, the role that dopamine plays in a region of the brain called the hippocampus. [More]

Aspartic acid in hippocampus may be biomarker for predicting occurrence of cognitive dysfunction

Postoperative cognitive dysfunction is the deterioration of cognitive performance after anesthesia and surgery, and manifests as impairments in short-term memory, concentration, language comprehension, and social integration skills. [More]
Early life chronic stress may cause anxiety in adulthood, says study

Early life chronic stress may cause anxiety in adulthood, says study

In recent years, behavioral neuroscientists have debated the meaning and significance of a plethora of independently conducted experiments seeking to establish the impact of chronic, early-life stress upon behavior - both at the time that stress is experienced, and upon the same individuals later in life, during adulthood. [More]
New subcellular mechanism identified for fast transmission in basket cells of the brain

New subcellular mechanism identified for fast transmission in basket cells of the brain

In his third major research paper since December 2013, IST Austria Professor Peter Jonas together with his collaborator, postdoc Hua Hu, identifies a new subcellular mechanism for reliable, fast transmission in the so-called basket cells of the brain. [More]
People who develop diabetes in middle age are more likely to have brain cell loss in old age

People who develop diabetes in middle age are more likely to have brain cell loss in old age

People who develop diabetes and high blood pressure in middle age are more likely to have brain cell loss and other damage to the brain, as well as problems with memory and thinking skills, than people who never have diabetes or high blood pressure or who develop it in old age, according to a new study published in the March 19, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology. [More]

Biological basis for visual hallucinations identified

Visual hallucinations in patients with schizophrenia may be caused by hyperconnectivity in a specific area of the brain, say researchers. [More]
Sea lions exposed to toxin in algae develop form of epilepsy that is similar to humans

Sea lions exposed to toxin in algae develop form of epilepsy that is similar to humans

California sea lions exposed to a toxin in algae develop a form of epilepsy that is similar to one in humans, according to a new study led by Stanford University School of Medicine researchers. [More]

Research reveals that hippocampus stores memories by their temporal context

Before I left the house this morning, I let the cat out and started the dishwasher. Or was that yesterday? Very often, our memories must distinguish not just what happened and where, but when an event occurred - and what came before and after. [More]

Study: Musical aptitude is affected by a combination of genes involved in auditory pathway

Multiple regions in the human genome are reported to be linked to musical aptitude, according to a study published this week in Molecular Psychiatry. [More]

Pretreatment with SSTF prevents cerebral ischemia-reperfusion injury, says study

Focal cerebral ischemia-reperfusion may lead to neuronal loss in the hippocampus, which is regarded as one of the basic pathological mechanisms underlying cognitive impairment. [More]
Stem cells from patients offer model, drug-discovery platform for early-onset form of Alzheimer's

Stem cells from patients offer model, drug-discovery platform for early-onset form of Alzheimer's

Harvard stem cell scientists have successfully converted skins cells from patients with early-onset Alzheimer's into the types of neurons that are affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells. This may also make it possible to develop therapies far more quickly and accurately than before. [More]

Further support for hippocampal volume as psychosis biomarker

Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes provide further evidence that reduced hippocampal volume is a consistent feature of schizophrenia. [More]
Cognitive decline in obese diabetic mice can be reversed with regular exercise, surgical removal of belly fat

Cognitive decline in obese diabetic mice can be reversed with regular exercise, surgical removal of belly fat

Cognitive decline that often accompanies obesity and diabetes can be reversed with regular exercise or surgical removal of belly fat, scientists report. [More]

Increased brain cell activity boosts protein linked to Alzheimer's disease

Increased brain cell activity boosts brain fluid levels of a protein linked to Alzheimer's disease, according to new research from scientists at Washington University School of Medicine in St. Louis. [More]

Electrical stimulation of hippocampus activates dormant memory cells

The electrical stimulation of the hippocampus in in-vivo experiments activates precisely the same receptor complexes as learning or memory recall. This has been discovered for the first time and the finding has now been published in the highly respected journal "Brain Structure Function". [More]